Testicular function and fertility preservation after treatment for haematological cancer

Jahnukainen, Kirsi; Mitchell, Rod T; Stukenborg, Jan-Bernd

doi:10.1097/med.0000000000000156

Cited by 50 publications

(50 citation statements)

References 60 publications

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“…After washing and cutting the testicular tissues, small testicular tissue fragments (AE6 mm 3 ;) were [1] fixed for reference histology, immunohistochemistry, and immunofluorescence, [2] used for gene expression analysis, [3] stored in liquid nitrogen (LN 2 ) after cryopreservation in minimal essential medium with 8% (v/v) dimethyl sulfoxide (Sigma-Aldrich, Diegem, Belgium) and 20% (v/v) fetal calf serum (Life Technologies, Gent, Belgium) by means of slow freezing using an isopropyl alcohol container (for cell culture after tissue cryopreservation) (5), or [4] kept on ice until digestion (for cell culture using fresh tissue). All testicular tissues used in this study showed normal spermatogenesis as proven by histology.…”

Section: Human Testis Materialsmentioning

confidence: 99%

“…It starts with the cryopreservation of testicular tissue, which is stored until the tissue or its cells are ultimately used for in vivo or in vitro sperm production, and ends with natural conception or artificial reproduction (1)(2)(3). When considering tissue dissociation for SSC transplantation, it is known that the success of fertility preservation is proportional to the amount of stem cells available as their colonization efficiency after transplantation has proven to be rather limited (4).…”

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confidence: 99%

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Cryopreservation of testicular tissue before long-term testicular cell culture does not alter in vitro cell dynamics

Baert

Braye

Struijk

et al. 2015

Fertility and Sterility

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Section: Human Testis Materialsmentioning

confidence: 99%

mentioning

confidence: 99%

Cryopreservation of testicular tissue before long-term testicular cell culture does not alter in vitro cell dynamics

Baert

Braye

Struijk

et al. 2015

Fertility and Sterility

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“…52,53 Experimental techniques in men include testicular tissue cryopreservation, which is subject to the same concerns and challenges as ovarian tissue banking, with perhaps even greater worry about tissue contamination in patients with ALL, as the testis is a known sanctuary site. 54 Children Pre-pubertal children are candidates only for experimental approaches, such as harvesting gonadal tissue for cryopreservation. There is a significant and urgent need for further research to expand fertility preservation options, particularly, non-invasive approaches, in children.…”

Section: Menmentioning

confidence: 99%

Fertility issues in patients with hematologic malignancies

Loren

2015

Hematology

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An essential component of a cancer patient's comprehensive care is addressing potential threats to his or her reproductive health. Providers should discuss the risk of infertility with newly diagnosed patients and offer the chance to consult with a reproductive specialist as early as possible. Standard fertility preservation options include embryo or oocyte cryopreservation for women and sperm banking for men; all options for pre-pubertal children are experimental. Patients with hematologic malignancies are a distinct population in whom standard options may present special challenges, and alternative management strategies are being explored. Unique approaches in hematologic malignancy patients include experimental techniques, such as hormonal therapy, referrals to reproductive specialists after cancer treatment, or discontinuation of tyrosine kinase inhibitor therapy in appropriate chronic myelogenous leukemia patients. Importantly, expedited communication between hematologists and reproductive specialists may greatly enhance the quality of care for these patients. Facilitation of referrals will both improve the quality-of-life and expand the prospect of parenthood in survivors. There are ample opportunities to advance the field of oncofertility through additional research, especially in hematologic malignancy patients.

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“…Fertility preservation options are not explored systematically early in the cancer treatment timeline which can limit post-HCT options. Even after chemotherapy and pre-transplant, there may be opportunities to preserve fertility [34, 35]. There has been little research on understanding the psychological impact of infertility nor on interventions to help individuals and couple cope with the loss of fertility.…”

Section: Working Groupsmentioning

confidence: 99%

Engaging Patients in Setting a Patient-Centered Outcomes Research Agenda in Hematopoietic Cell Transplantation

Burns

Abbetti

Arnold

et al. 2018

Biology of Blood and Marrow Transplantation

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The goal of patient-centered outcomes research (PCOR) is to help patients and those who care for them make informed decisions about healthcare. However, the clinical research enterprise has not involved patients, caregivers, and other non-providers routinely in the process of prioritizing, designing and conducting research in hematopoietic cell transplantation (HCT). To address this need, the National Marrow Donor Program (NMDP)/Be The Match® engaged patients, caregivers, researchers and other key stakeholders in a two-year project with the goal of setting a PCOR agenda for the HCT community. Through a collaborative process, we identified six major areas of interest: 1) Patient, Caregiver and Family Education and Support; 2) Emotional, Cognitive and Social Health; 3) Physical Health and Fatigue; 4) Sexual Health and Relationships; 5) Financial Burden; and 6) Models of Survivorship Care Delivery. We then organized into multi-stakeholder Working Groups to identify gaps in knowledge and make priority recommendations for critical research to fill those gaps. Gaps varied by Working Group, but all noted that a historical lack of consistency in measures utilized and patient populations made it difficult to compare outcomes across studies and urged investigators to incorporate uniform measures and homogenous patient groups in future research. Some groups advised that additional pre-emptory work is needed before conducting prospective interventional trials, whereas others felt ready to proceed with comparative clinical effectiveness research studies. This report presents the results of this major initiative, and makes recommendations by Working Group on priority questions for PCOR in HCT.

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Testicular function and fertility preservation after treatment for haematological cancer

Cited by 50 publications

References 60 publications

Cryopreservation of testicular tissue before long-term testicular cell culture does not alter in vitro cell dynamics

Cryopreservation of testicular tissue before long-term testicular cell culture does not alter in vitro cell dynamics

Fertility issues in patients with hematologic malignancies

Engaging Patients in Setting a Patient-Centered Outcomes Research Agenda in Hematopoietic Cell Transplantation

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