Testicular Dysfunction in Systemic Diseases

Handelsman, David J.

doi:10.1007/978-3-662-04491-9_12

Cited by 6 publications

(7 citation statements)

References 85 publications

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“…Finally, it is known that impairment of sperm quality can be the direct or indirect consequence of several systemic diseases like liver and kidney diseases, diabetes or cancer (Handelsman, 2000;Karagiannis and Harsoulis, 2005). Thus, (iiii) cases with such known co-morbidities were excluded to assure that, at the time of examination, impairment of spermatogenesis was not the consequence of an existing disease.…”

Section: Data Basementioning

confidence: 99%

Men with subnormal sperm counts live shorter lives

Groos

Krause

Muêller

2006

Biodemography and Social Biology

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A lost less is known about the morbidity and mortality consequences of male infertility. It was the aim of our study to analyse the association between sperm concentration and individual lifetime mortality in men. The data sources included medical records of 601 men who attended the andrological service at the Marburg University Hospital between 1949 and 1985, and vital data gathered from public registration offices and a statutory health insurance. A Cox regression model estimated a two-fold higher mortality risk for oligozoospermic men as compared to the normozoospermic group for cohorts born between 1892 and 1931. Since a selection bias could not be found, we assume there to be a connection between poor fertility status and a shorter lifespan in men. Possible explanations for the variation in mortality risk are: (i) Lifestyle and health behaviour in adulthood, (ii) conditions in utero, and (iii) genetic dispositions.

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Section: Data Basementioning

confidence: 99%

Men with subnormal sperm counts live shorter lives

Groos

Krause

Muêller

2006

Biodemography and Social Biology

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“…Gastrointestinal diseases resulting in maldigestion or malabsorption and, therefore, undernutrition can also have a suppressive effect on testosterone secretion (182). Hyperthyroidism, haematological and autoimmune diseases can also alter androgen production (183,184).…”

Section: Influence Of Systemic Non-gonadal Diseases On Testosterone Lmentioning

confidence: 99%

“…Androgen receptors can be blocked by cimetidine or spironolactone. Testosterone metabolism can be increased via hepatic enzyme induction by barbiturates and other anticonvulsants (183). The use of medication can, especially in uncontrolled, cross-sectional studies, contribute to a bias distorting the results concerning endocrine secretion patterns.…”

Section: Influence Of Medications On Testosterone Levelsmentioning

confidence: 99%

Testosterone levels in healthy men and the relation to behavioural and physical characteristics: facts and constructs

Zitzmann¹,

Nieschlag²

2001

Eur J Endocrinol

206

122

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This review summarises the correlations between testosterone levels and male physical appearance and behaviour. Methodological shortcomings concerning the measurement of testosterone could limit the value of these findings. In addition, testosterone measured in body fluids represents only one step in the cascade of action from production to biological effect, and could therefore provide only a limited view of the complexity of physiological events. Testosterone levels are influenced by conditions that are partly controlled or initiated by the hormone itself, but also by circumstances beyond hormonal or individual control. Different kinds of behaviour are not only subject to influence by environment, but also androgens can reinforce the particular kind of conduct and the behavioural impact can wield negative or positive feedback on testosterone secretion. Therefore, both generalisation and individualisation of study results will lead to doubtful conclusions and prejudices. Results of such studies must be viewed with caution, and over-simplification as well as over-interpretation should be avoided.

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“…Decreased anabolic hormone levels are commonly described in several chronic or critical illnesses, including chronic respiratory diseases (1,2). Peripheral muscle wasting, osteoporosis, sexual dysfunction, immunological alterations, memory loss, diminished energy and vitality are among the clinical consequences of hypogonadal state (1,3,4).…”

Section: Introductionmentioning

confidence: 99%

Sex hormone alterations and systemic inflammation in chronic obstructive pulmonary disease

Karadağ¹,

Özcan²,

Karul

et al. 2009

International Journal of Clinical Practice

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Summary Objective: Decreased anabolic hormone levels are described in chronic obstructive pulmonary disease (COPD), leading to important clinical consequences. The aim of this study was to evaluate the alterations in sex hormone levels in men with COPD to compare with age‐matched control subjects, the determinants of these alterations, the relationship between hypogonadism and markers of systemic inflammation [interleukin‐6 (IL‐6) and tumour necrosis factor alpha (TNF‐α)] and the androgen status during an acute exacerbation of COPD. Methods: A total of 103 COPD patients and 30 control subjects were admitted to the study. 83 stable COPD patients and 30 control subjects were evaluated as outpatients. 20 patients with COPD exacerbation were hospitalised and evaluated before discharge and after 1 month. Results: Testosterone and dehydroepiandrosteronesulphate (DHEAS) levels of both COPD groups were lower than that of the control group. Luteinizing hormone (LH), follicle stimulating hormone (FSH) levels were increased during exacerbation. Testosterone and DHEAS levels increased and LH decreased in follow‐up measurements of COPD exacerbation group. Testosterone and DHEAS levels were lower in severe COPD [forced expiratory volume in 1 s (FEV1) < 50%], in patients with severe hypoxaemia (PaO2 < 60 mmHg) and in hypercapnic patients. Circulating IL‐6 and TNF‐α concentrations were higher in both stable and exacerbation phase COPD groups than controls. There was no correlation between sex hormones and TNF‐α or IL‐6. Conclusion: The alterations in sex hormone levels in COPD are particularly related to FEV1, hypoxaemia and hypercapnia. There are significant differences in hormone levels during stable and exacerbation phases of COPD; the hormonal changes are marked during exacerbation and partially regress after 1 month when the disease is stabilised.

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Testicular Dysfunction in Systemic Diseases

Cited by 6 publications

References 85 publications

Men with subnormal sperm counts live shorter lives

Men with subnormal sperm counts live shorter lives

Testosterone levels in healthy men and the relation to behavioural and physical characteristics: facts and constructs

Sex hormone alterations and systemic inflammation in chronic obstructive pulmonary disease

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