Testicular Cancer in the United States: Trends in Incidence and Mortality

Brown, Linda Morris; Pottern, Linda M.; Hoover, Robert N.; Devesa, Susan S.; Aselton, Pamela; Flannery, John

doi:10.1093/ije/15.2.164

Cited by 116 publications

(34 citation statements)

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“…We found an increasing risk for seminoma with increasing milk fat intake and an even stronger association between galactose consumption and seminoma especially in the younger men ages 15 to 34 years. Although several epidemiologic studies indicate that risk factors for seminoma and nonseminoma may differ (13,16,(24)(25)(26)(27)(28)(29), it is unclear whether the specificity of the observed effects in our study (no association with nonseminoma risk) is causal or not because the subgroup of nonseminoma patients was small, resulting in imprecise effect estimates. In their registry-based prevalence case-control study, Davies et al (6) found that the RR per 1/4 pint of milk per day (i.e., f120 mL per day) at age 17 years was 1.39 (95% CI, 1.19-1.63).…”

Section: Discussioncontrasting

confidence: 56%

Adolescent Milk Fat and Galactose Consumption and Testicular Germ Cell Cancer

Stang

Ahrens

Baumgardt-Elms

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Recent case-control studies suggested that dairy product consumption is an important risk factor for testicular cancer. We examined the association between consumption of dairy products, especially milk, milk fat, and galactose, and testicular cancer in a population-based case-control study including 269 case and 797 controls (response proportions of 76% and 46%, respectively). Dietary history was assessed by food frequency questions for the index persons and through their mothers including diet 1 year before interview and diet at age 17 years. We used conditional logistic regression to calculate odds ratios as estimates of the relative risk (RR), 95% confidence intervals (95% CI), and to control for social status and height. The RR of testicular cancer was 1.37 (95% CI, 1.12-1.68) per additional 20 servings of milk per month (each 200 mL) in adolescence. This elevated overall risk was mainly due to an increased risk for seminoma (RR, 1.66; 95% CI, 1.30-2.12) per additional 20 milk servings per month. The RR for seminoma was 1.30 (95% CI, 1.15-1.48) for each additional 200 g milk fat per month and was 2.01 (95% CI, 1.41-2.86) for each additional 200 g galactose per month during adolescence. Our results suggest that milk fat and/or galactose may explain the association between milk and dairy product consumption and seminomatous testicular cancer. (Cancer Epidemiol Biomarkers Prev 2006;15(11):2189 -95)

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Section: Discussioncontrasting

confidence: 56%

Adolescent Milk Fat and Galactose Consumption and Testicular Germ Cell Cancer

Stang

Ahrens

Baumgardt-Elms

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Mortality risk from TC reaches its peak between ages 20 and 34 and drops to a stabilization of rates near the age of 40 (age effect), as it has been observed in previous studies in Western and Eastern European countries [2]. The increased incidence risk of testicular cancer was detected for men 15-44 in most industrialized countries [2,[28][29][30][31][32]. Spain has noted recently the most rapid inclines in TC incidence among European countries, although it has one of the lowest TC incidence and mortality rates in Europe [1,2].…”

Section: Discussionsupporting

confidence: 56%

Monitoring the decreasing trend of testicular cancer mortality in Spain during 2005–2019 through a Bayesian approach

Clèries

Martı́nez

Escribà

et al. 2010

Cancer Epidemiology

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“…Testicular cancer incidence is much lower in Finland than in Denmark and the other Nordic countries (10). Furthermore, testicular cancer incidence is higher among the white than the black population in the USA (29,30). This suggests that genetic factors have an impact on testicular function.…”

Section: Discussionmentioning

confidence: 99%

Semen quality among Danish and Finnish men attempting to conceive. The Danish First Pregnancy Planner Study Team

Jensen¹,

Vierula²,

Hjøllund³

et al. 2000

Eur J Endocrinol

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Objective: To assess differences in semen quality between similar populations from Denmark and Finland. Design: Comparison of semen quality between 221 Finnish men (of whom 115 had no proven fertility) and 411 Danish men with no proven fertility in two follow-up studies among normal couples trying to conceive. Methods: In Finland male partners of couples without experienced infertility attempting to conceive were recruited through advertisements in local newspapers from 1984 to 1986. From 1992 to 1995 Danish men who lived with a partner and who had not attempted to achieve a pregnancy previously were recruited through their union when they discontinued birth control. All semen analyses were performed in accordance with the World Health Organization guidelines. Results: Median sperm concentration, total sperm count and the percentage of morphologically normal spermatozoa were significantly higher among the Finnish men without proven fertility (104.0 million/ml, 304.0 million and 58% respectively) compared with the Danish men (53.0 million/ml, 140.8 million, and 41% respectively). Sperm concentration was 105.7% (95% confidence interval (CI) 58.1%-167.6%) and total sperm count was 127.4% (95% CI 71.4%-201.6%) higher among Finnish men without proven fertility than among Danish men after control for confounders. Conclusions: Some, but hardly all, of the observed difference in semen quality may be explained by differences in recruitment procedures, selection of the men and by methodological differences in semen analysis between the two countries. Also a birth cohort effect may explain some of the differences between countries as the Finnish men were recruited 11 years before the Danish men. Therefore, follow-up studies with identical recruitment and selection of men from the two countries are needed.

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Testicular Cancer in the United States: Trends in Incidence and Mortality

Cited by 116 publications

References 0 publications

Adolescent Milk Fat and Galactose Consumption and Testicular Germ Cell Cancer

Adolescent Milk Fat and Galactose Consumption and Testicular Germ Cell Cancer

Monitoring the decreasing trend of testicular cancer mortality in Spain during 2005–2019 through a Bayesian approach

Semen quality among Danish and Finnish men attempting to conceive. The Danish First Pregnancy Planner Study Team

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