Testicular cancer among US men aged 50 years and older

Ghazarian, Armen A.; Rusner, Carsten; Trabert, Britton; Braunlin, Megan; McGlynn, Katherine A.; Stang, Andreas

doi:10.1016/j.canep.2018.05.007

Cited by 28 publications

(22 citation statements)

References 21 publications

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“…Even though the median age at diagnosis of spermatocytic tumor is age 50 years, the incidence is always lower than that of seminoma. Although previous studies have found modest, nonsignificant, increases (61) and decreases (4) in the rates of spermatocytic tumor, the finding a statistically significant decrease in incidence is novel.…”

Section: Discussionmentioning

confidence: 77%

Increasing Incidence of Testicular Germ Cell Tumors among Racial/Ethnic Minorities in the United States

Ghazarian

McGlynn

2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: The incidence of testicular germ cell tumors (TGCT) has been rising in the United States and is notably higher among white men. Previously, our group reported that rates were rising among Hispanic men in certain areas. This study sought to determine whether the patterns noted in our prior publication remained evident in more recent years and to determine whether any new patterns have emerged.Methods: Data from 51 U.S. cancer registries were examined. Racial/ethnic-specific incidence rates per 100,000 man-years were calculated overall and by census region. Annual percent changes (APC) were estimated, and joinpoint models were fit. Differences in regional incidence were examined using the Wald test.Results: During the time period 2001 to 2016, 126,575 TGCTs were recorded. TGCT incidence was highest among non-Hispanic whites (NHW; 6.63/100,000), followed by Hispanics (4.20), American Indian/Alaska Natives (AI/AN; 3.27), Asian/ Pacific Islanders (A/PI; 1.72), and non-Hispanic blacks (NHB; 1.27). TGCT incidence increased significantly among all men; the greatest increase was experienced by A/PIs (APC: 2.47), followed in order by Hispanics (2.10), AI/ANs (1.71), NHBs (1.28), and NHWs (0.41). Significant differences in rates by region were seen for all men except NHBs, with the highest rates among Hispanics (5.38/ 100,000), AI/ANs (4.47), and A/PIs (2.37) found in the West, and among NHWs (7.60) and NHBs (1.51) found in the Northeast.Conclusions: Although TGCT incidence remained highest among NHWs between 2001 and 2016, the greatest increase was experienced by A/PI men.Impact: Rising rates of TGCTs among men of all racial/ethnic backgrounds in the United States suggest that future attention is warranted.

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Section: Discussionmentioning

confidence: 77%

Increasing Incidence of Testicular Germ Cell Tumors among Racial/Ethnic Minorities in the United States

Ghazarian

McGlynn

2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…PT-DLBCL accounts for 80-98% of all primary testicular lymphomas and~1% of all non-Hodgkin lymphoma cases. 104,105 PT-DLBCL is the most common testicular cancer among men >50-60 years of age. The median age is 65 years (range 10-96 years).…”

Section: Epidemiologymentioning

confidence: 99%

Diffuse large B-cell lymphoma variants: an update

et al. 2020

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“…Tumors originating from testicular adnexa, including rete testis, or tunica vaginalis (mesothelial cells) and some embryonic structures that normally involute during fetal life, such a műllerian ducts, are also quite rare (16)(17)(18)(19)(20). Metastatic tumors to the testis and lymphoma are rare but must be considered in the differential diagnosis, especially in elderly patients (21,22).…”

Section: Clinical Sciencementioning

confidence: 99%

Testicular Germ Cell Tumors: Serological and Immunohistochemical Diagnosis

Damjanov

2021

ama

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This review deals with serologic and immunohistochemical tumor markers used in clinical laboratories for the diagnosis of testicular germ cell tumors. Time tested serologic markers such as alpha-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase are routinely used in the work-up of patients with testicular tumors. Professional organizations regulating the practice of medicine in most countries worldwide require that the laboratory values for these serologic reactants be included in the pathology reports on testicular tumors as part of the tumor staging process. Immunohistochemical markers of testicular germ have been identified and widely tested during the first two decades of the XXI century. We have selected the most useful immunohistochemical markers from a few of these markers and discussed them in this review.Conclusion. Published data show that testicular tumor markers are widely used in routine practice. The study of tumor markers has improved the pathologic and clinical diagnosis of testicular germ cell tumors and has thus contributed to their treatment.

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Testicular cancer among US men aged 50 years and older

Abstract: Given the distinct time-trends and age-specific patterns of testicular cancer in men aged ≥50 years, additional investigation of risk factors for these tumors is warranted.

Cited by 28 publications

References 21 publications

Increasing Incidence of Testicular Germ Cell Tumors among Racial/Ethnic Minorities in the United States

Increasing Incidence of Testicular Germ Cell Tumors among Racial/Ethnic Minorities in the United States

Diffuse large B-cell lymphoma variants: an update

Testicular Germ Cell Tumors: Serological and Immunohistochemical Diagnosis

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