Testicular Adrenal Rest Tumors (TARTS) With Unusual Histological Features in Congenital Adrenal Hyperplasia (CAH)

Abstract

Congenital adrenal hyperplasia (CAH) patients with testicular adrenal rest tumors (TARTs) with testicular enlargement present a serious diagnostic challenge. According to the data TARTs are usually benign. They are rare, resulting in paucity in the medical literature regarding their pathological features. We report a case of bilateral synchronous mass-forming TARTs with marked cytological and nuclear atypia misinterpreted as malignant testicular tumors in a 40-years-old man with CAH and CT and MRI data for pheochromocytoma of the right adrenal gland and paraaortal and paracaval lymphadenomegaly. He was previously diagnosed with adrenal cortical carcinoma of the left adrenal gland.

Renal Endometriosis Mimicking a Malignancy—a Rare Case of Reno-Mullerian Fusion?

“…Such ectopic misplacement or fusion of tissue at embryogenesis is recognised in other areas of human biology. For example, adrenal cortical rests in the testes and testicular adnexa occur frequently, not just in exclusive cases of congenital adrenal hyperplasia (14). In addition, splenogonadal fusion is a recognised anomaly, which is characterised by congenital fusion between the spleen and testicular tissue, often presenting as a testicular mass.…”