Test-Retest Variability of Topographic Measurements With Confocal Scanning Laser Tomography in Patients With Glaucoma and Control Subjects

Chauhan, Balwantray C.; LeBlanc, Raymond P.; McCormick, Terry A.; Rogers, Jamie B.

doi:10.1016/s0002-9394(14)72836-3

Cited by 172 publications

(83 citation statements)

References 14 publications

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“…Details of this technique were previously published. [20][21][22][23][24][25] HRT is a confocal scanning diode laser with a wavelength of 670 nm. A series of 32 confocal images are obtained at consecutive focal planes, each 256 pixels Â 256 pixels in size that the computer converts into a single topographic image.…”

Section: Hrtmentioning

confidence: 99%

Retinal nerve fibre layer measurements and optic nerve head analysis in multiple sclerosis patients

Iester

Cioli

Uccelli

et al. 2007

Eye

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Purpose To verify whether scanning laser polarimeter with the new variable corneal compensation algorithm (GDx VCC) and scanning laser ophthalmoscopy (Heidelberg Retina Tomograph (HRT)) allow measuring retinal ganglion cell loss in patients with multiple sclerosis (MS). Patients and methods We enrolled 23 MS patients with a history of previous demyelinating monocular optic neuritis. Examination included visual evoked potentials (VEPs), scanning laser ophthalmoscopy, and scanning laser polarimeter. HRT was performed to assess optic nerve head (ONH) shape, while GDx VCC was used to evaluate the retinal nerve fibre layer thickness (RNFLt) around the ONH. Statistical analysis was performed comparing results obtained for each eye with the available normative database and with the unaffected fellow eye. Results When the affected eye group was compared to the fellow-eye group, a significant (Po0.05) difference was found for few GDx VCC parameters. In contrast, no significant correlation was observed between clinical assessment and imaging techniques when the normal database of HRT and GDx VCC was used. A significant association was observed between VEP latency and some GDx VCC parameters. Conclusions Our results suggested that scanning laser polarimetry could detect loss of ganglion cells following demyelinating optic neuritis, but further studies are needed.

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Section: Hrtmentioning

confidence: 99%

Retinal nerve fibre layer measurements and optic nerve head analysis in multiple sclerosis patients

Iester

Cioli

Uccelli

et al. 2007

Eye

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“…So far, SLO-studies have mainly evaluated the usefulness of optic disc parameters for glaucoma detection, their reproducibility of measurements and any correlations with visual field defects. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] However, relatively little attention has been paid to the possible value of SLO optic disc biometry for improvement of glaucoma follow-up. [20][21][22] To reliably detect development or progression of disease with a certain measurement parameter, it is necessary to know the absolute difference between follow-up measurements that must be exceeded to detect a statistically significant change over time.…”

Section: Introductionmentioning

confidence: 99%

Estimating the clinical usefulness of optic disc biometry for detecting glaucomatous change over time

Tangelder

Reus

Lemij

2005

Eye

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Purpose First, to determine the absolute measurement precision of scanning laser ophthalmoscopy (SLO) parameters, by expressing them as 95% limits of agreement (LA 95% ). Second, to propose a method for mathematically estimating the clinical ability of a parameter to monitor disease progression, expressed as the Discriminating Capacity Index (DCI). Methods We measured the optic disc of 14 healthy volunteers and 14 glaucoma patients. LA 95% -values were calculated from the average standard deviation of three measurements on the same day for repeatability, and three measurements on separate days within a 6-week period for reproducibility. We then calculated the DCI by dividing the measurement range by its LA 95% in healthy subjects and glaucoma patients separately. Thus, the DCI takes into account both the dynamic range of disease progression and the extent of measurement variance, providing an index of the possible clinical usefulness of a parameter. As the DCI is dimensionless it allows comparison across various parameters and across technologies.

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“…Even if each image is made by many points, users prefer to employ standard parameters for each system and do not use all the available data. [13][14][15][16][17][18][19][20][21][22] To obtain parameter measurements, an outline had to be drawn around the outer optic disc edge and although this technique had a good reproducibility, the contour line position could change from one center to another. 10 The anatomical variability of normal ONH shape makes it difficult to differentiate normal from glaucomatous optic discs.…”

Section: Discussionmentioning

confidence: 99%

“…The accuracy and reproducibility of this instrument have previously been described in detail. [13][14][15][16][17][18][19][20][21][22] The HRT uses a scanning confocal laser imaging system, which produces a series of 32 confocal images of the back of the eye at consecutive focal planes, each 256 Â 256 pixels. This series is converted by further processing into a single 3-D topographic image.…”

Section: Optic Nerve Head Topographic Analysismentioning

confidence: 99%

Detection of glaucomatous optic nerve head by using Heidelberg topographic maps

Iester

Zanini

Vittone

et al. 2006

Eye

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Test-Retest Variability of Topographic Measurements With Confocal Scanning Laser Tomography in Patients With Glaucoma and Control Subjects

Cited by 172 publications

References 14 publications

Retinal nerve fibre layer measurements and optic nerve head analysis in multiple sclerosis patients

Retinal nerve fibre layer measurements and optic nerve head analysis in multiple sclerosis patients

Estimating the clinical usefulness of optic disc biometry for detecting glaucomatous change over time

Detection of glaucomatous optic nerve head by using Heidelberg topographic maps

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