Test–Retest Variability of Microperimetry Using the Nidek MP1 in Patients with Macular Disease

Chen, Fred K.; Patel, Praveen J; Xing, Wen; Bunce, Catey; Egan, Catherine; Tufail, Adnan; Coffey, Peter; Rubin, Gary S.; Cruz, Lyndon da

doi:10.1167/iovs.08-2926

Cited by 135 publications

(122 citation statements)

References 46 publications

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“…22 Using the same MP-1 unit at all visits, we recorded a 2.2 dB decrease in mean MS at 5 to 6 years after RD surgery, as compared with results at 18-month check. As test-retest variability of MS in patients with macular disease does not exceed 2 dB, 23 other factors, including patients' concentration during testing session should have had a role in MS decrease, especially in patient 4 with high myopia and a 9.5 dB reduction at the final visit.…”

Section: Discussionmentioning

confidence: 99%

Long-term follow-up with optical coherence tomography and microperimetry in eyes with metamorphopsia after macula-off retinal detachment repair

Rossetti

Doro

Manfre

et al. 2010

Eye

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Purpose To report the long-term sequential morphological and functional results in eyes with metamorphopsia after retinal detachment (RD) repair. Patients and methods In six eyes of six patients aged 58.7±11.0 years with metamorphopsia after successful buckling surgery for macula-off RD, best-corrected visual acuity (BCVA), fundus biomicroscopy, Amsler grid test, time-domain optical coherence tomography (TD-OCT) and central 121 microperimetry (MP-1) were performed at months 1, 3, 6, 12, and 18. At 5 to 6 years after surgery all patients underwent also spectral domain (SD)-OCT. Results Three eyes slowly recovered pre-RD BCVA. In the remaining three eyesFwith good final BCVAFthe interrupted junction line between photoreceptor cell inner and outer segments (IS/OS) was progressively less evident after RD surgery; and the external limiting membrane was preserved on SD-OCT examination. In all eyes post-operative metamorphopsia faded with time, but fully disappeared in 6 years only in two eyes without photoreceptor abnormalities. One of the two eyes with subretinal fluid up to 6 months and IS/OS disruption had central dense scotoma with relatively unstable fixation on MP-1 and persistent metamorphopsia. Macular sensitivity (MS) increased from 9.7 ± 7.1 at month 1 to 13.5 ± 5.6 dB at the final check, and was weakly (r ¼ 0.33) correlated with post-operative BCVA and OCT abnormalities. Conclusion Long-standing metamorphopsia can occur after successful macula-off RD repair even without detectable photoreceptor disruption on OCT. Post-operative BCVA recovery weakly correlates with increasing MS, and late restoration of the photoreceptor layer may be observed

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Section: Discussionmentioning

confidence: 99%

Long-term follow-up with optical coherence tomography and microperimetry in eyes with metamorphopsia after macula-off retinal detachment repair

Rossetti

Doro

Manfre

et al. 2010

Eye

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“…Intersession test-retest variability of different microperimetric parameters with SLO perimetry and MP-1 Nidek microperimetry, such as average threshold, fixation stability, and macular integrity, within different populations has been reported recently [2,4,[7][8][9][10].…”

Section: Discussionmentioning

confidence: 95%

“…As shown in earlier studies, automatic fundus perimetry and the first microperimetry that uses a true eye-tracking system (MP1) allow accurate, repeatable, and topographically specific examination of retinal sensitivity [4,[7][8][9][10][11][12].…”

Section: Discussionmentioning

confidence: 98%

“…A number of studies have investigated test-retest variability of mean sensitivity with MP-1 microperimetry [4,7,8]. Weingessel et al [4], for instance, showed good reliability for macular sensitivity and fixation stability in healthy subjects and AMD patients by using (MP-1) in patients with different macular diseases and showed that the test-retest variability is lowest for mean sensitivity and highest for point-wise sensitivity.…”

Section: Discussionmentioning

confidence: 99%

“…Nidek MP-1 microperimetry. Chen et al [7] analyzed fixation stability recorded during microperimetry Coefficient of variability and reproducibility of average thresholds and fixation stability in healthy subjects and AMD patients Upper graphs show the coefficient of variability (COV) of the average threshold and the fixation stability in both groups. Lower graphs show the mean differences of the standard deviation (SD) of the average threshold and fixation stability.…”

Section: Discussionmentioning

confidence: 99%

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Retinal Sensitivity and Fixation Stability Changes during Repeated Microperimetry

Szepessy¹,

Barboni²,

Nagy³

et al. 2017

J Clin Exp Ophthalmol

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Purpose: To determine and compare the intersession test-retest variability of different microperimetric parameters in healthy volunteers and age-related macular degeneration (AMD) patients by MAIA microperimetry.Methods: Twenty-four eyes of 12 healthy volunteers and 22 eyes of 11 AMD patients were included in this study. Microperimetry examinations were performed three times on each eye of all participants by MAIA microperimetry (CenterVue, Padova, Italy). The second measurement was performed on the same day and the third measurement one week after the first test. Retinal light sensitivity, stability of fixation, and macular integrity were recorded. Statistical analysis was performed by Microsoft Excel software and StatSoft Statistica software.Results: During the examinations, the average threshold had not changed significantly (p>0.475) in time in healthy and AMD patients. Fixation stability was relatively constant (nearly 100%) in healthy subjects as compared to the increase in the improving eye condition of AMD patients (p=0.042). Macular integrity was stable in both groups during the examinations. Conclusion:A learning effect was found in fixation stability of AMD patients by MAIA microperimetry. The improvement in fixation stability might be considered, especially prior to biofeedback training protocols in AMD patients.

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The Microperimetry of Resolved Cotton-Wool Spots in Eyes of Patients With Hypertension and Diabetes Mellitus

Kim¹

2011

Arch Ophthalmol

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Background: Retinal cotton-wool spots (CWSs) are an important manifestation of retinovascular disease in hypertension (HTN) and diabetes mellitus (DM). Conventional automated perimetry data have suggested relative scotomas in resolved CWSs; however, this has not been well delineated using microperimetry. This study evaluates the retinal sensitivity in documented resolved CWSs using microperimetry. Methods: Retinal CWSs that resolved after 10 to 119 months (median, 51 months) and normal control areas were photographed to document baseline lesions. Eyetracking, image-stabilized microperimetry with simultaneous scanning laser ophthalmoscopy was performed over resolved CWSs, adjacent uninvolved areas near the lesion, and in location-matched normal patients (age-matched). Results: A total of 16 eyes in patients with DM or HTN (34 resolved CWSs) and 16 normal control eyes (34 areas) were imaged. The mean (SD) sensitivity of resolved CWSs in the eyes of patients with HTN and DM was 11.67 (3.88) dB and 7.21 (5.48) dB, respectively. For adjacent control areas in the eyes of patients with HTN and DM, the mean (SD) sensitivity was 14.00 (2.89) dB and 11.80 (3.45) dB, respectively. Retinal sensitivity was significantly lower in areas of resolved CWSs than in the surrounding controls for patients with HTN (P = .01) and those with DM (PϽ.001). Scotomas in patients with DM were denser than those of patients with HTN (PϽ.05). Conclusions: Cotton-wool spots in patients with DM and HTN leave permanent relative scotomas detected by microperimetry. Scotomas are denser in eyes of patients with DM than in those with HTN. In addition, among patients with DM, adjacent retinas not involved with CWSs have lower retinal sensitivity than in age-matched controls.

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Test–Retest Variability of Microperimetry Using the Nidek MP1 in Patients with Macular Disease

Cited by 135 publications

References 46 publications

Long-term follow-up with optical coherence tomography and microperimetry in eyes with metamorphopsia after macula-off retinal detachment repair

Long-term follow-up with optical coherence tomography and microperimetry in eyes with metamorphopsia after macula-off retinal detachment repair

Retinal Sensitivity and Fixation Stability Changes during Repeated Microperimetry

The Microperimetry of Resolved Cotton-Wool Spots in Eyes of Patients With Hypertension and Diabetes Mellitus

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