Test-retest reliability of transcranial magnetic stimulation EEG evoked potentials

Kerwin, Lewis; Keller, Corey J.; Wu, Wei; Narayan, Manjari; Etkin, Amit

doi:10.1016/j.brs.2017.12.010

Cited by 116 publications

(119 citation statements)

References 32 publications

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“…Evidence of within-subject reproducibility has also been observed in CCEP and TEP research (Kerwin, Keller, Wu, Narayan, & Etkin, 2017; Zumsteg, Lozano, Wieser, et al, 2006b). Taken together, this literature suggest a strategy to develop an objective, physiological alternative to patient self-report for confirmation of optimal target engagement and parameter selection in individual patients over the course of treatment.…”

Section: Introductionmentioning

confidence: 67%

“…In addition to these theoretical insights, the viability of a noninvasive approach (i.e., electroencephalography [EEG]) to measuring a DBS evoked potential, which we employed, has been demonstrated by Zumsteg et al (Zumsteg, Lozano, & Wennberg, 2006a;Zumsteg, Lozano, Wieser, & Wennberg, 2006b). Evidence of within-subject reproducibility has also been observed in CCEP and TEP research (Kerwin, Keller, Wu, Narayan, & Etkin, 2017;Zumsteg, Lozano, Wieser, et al, 2006b). Taken together, this literature suggest a strategy to develop an objective, physiological alternative to patient selfreport for confirmation of optimal target engagement and parameter selection in individual patients over the course of treatment.…”

Section: Introductionmentioning

confidence: 98%

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Test–retest reliability of a stimulation‐locked evoked response to deep brain stimulation in subcallosal cingulate for treatment resistant depression

Waters

Veerakumar²,

Choi

et al. 2018

Human Brain Mapping

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Deep brain stimulation (DBS) to the subcallosal cingulate cortex (SCC) is an emerging therapy for treatment resistant depression. Precision targeting of specific white matter fibers is now central to the model of SCC DBS treatment efficacy. A method to confirm SCC DBS target engagement is needed to reduce procedural variance across treatment providers and to optimize DBS parameters for individual patients. We examined the reliability of a novel cortical evoked response that is time-locked to a 2 Hz DBS pulse and shows the propagation of signal from the DBS target. The evoked response was detected in four individuals as a stereotyped series of components within 150 ms of a 6 V DBS pulse, each showing coherent topography on the head surface. Test-retest reliability across four repeated measures over 14 months met or exceeded standards for valid test construction in three of four patients. Several observations in this pilot sample demonstrate the prospective utility of this method to confirm surgical target engagement and instruct parameter selection. The topography of an orbital frontal component on the head surface showed specificity for patterns of forceps minor activation, which may provide a means to confirm DBS location with respect to key white matter structures. A divergent cortical response to unilateral stimulation of left (vs. right) hemisphere underscores the need for feedback acuity on the level of a single electrode, despite bilateral presentation of therapeutic stimulation. Results demonstrate viability of this method to explore patient-specific cortical responsivity to DBS for brain-circuit pathologies.

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Section: Introductionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 98%

Test–retest reliability of a stimulation‐locked evoked response to deep brain stimulation in subcallosal cingulate for treatment resistant depression

Waters

Veerakumar²,

Choi

et al. 2018

Human Brain Mapping

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“…We record TMS-evoked and resting-state EEG activity in schizophrenia patients and healthy controls, with 94 three repetitions for each participant. Evaluating both groups three times with one week between each 95 session strengthens the reliability of the results (see also (Kerwin et al, 2018)), as cortical responses may 96 vary with changes in symptoms (Naim-Feil et al, 2019). An advantage of TMS-EEG is that it does not 97 require active participation and attention of the schizophrenia patients ( Thirty healthy controls without any history of psychiatric illness, drug abuse or head injury were recruited 101 through local advertisements.…”

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confidence: 81%

Phase-amplitude markers of synchrony and noise: A resting-state and TMS-EEG study of schizophrenia

Freche

Naim-Feil

Hess

et al. 2019

Preprint

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AbstractThe electroencephalogram (EEG) of schizophrenia patients is known to exhibit a reduction of signal-to-noise ratio and of phase locking, as well as a facilitation of excitability, in response to a variety of external stimuli. Here we demonstrate these effects in transcranial magnetic stimulation (TMS)-evoked potentials and in the resting-state EEG. To ensure veracity we used three weekly sessions and analyzed both resting state and TMS-EEG data. For the TMS responses our analysis verifies known results. For the resting state we introduce the methodology of mean-normalized variation to the EEG analysis (quartile-based coefficient of variation), which allows for a comparison of narrow-band EEG amplitude fluctuations to narrow-band Gaussian noise. This reveals that amplitude fluctuations in the delta, alpha and beta bands of healthy controls are different from those in schizophrenia patients, on time scales of tens of seconds. We conclude that the EEG-measured cortical activity patterns of schizophrenia patients are more similar to noise, both in alpha and beta resting state and in TMS responses. Our results suggest that the ability of neuronal populations to form stable, locally and temporally correlated activity is reduced in schizophrenia, a conclusion that is in accord with previous experiments on TMS-EEG and on resting-state EEG.

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“…weeks) time periods. Indeed, high test-retest reliability has been demonstrated for single-pulse TEPs following stimulation of motor [3,30], premotor [4], dorsolateral prefrontal [3,5], superior parietal [4], and visual cortices [4] using a variety of different metrics. We further confirm the reliability of TEPs following stimulation of superior frontal and superior parietal cortex using a simple metric which takes into account the entire spatio-temporal TEP profile by comparing the mean absolute difference in TEP amplitude within-and between-individuals across sessions (i.e.…”

Section: Reliability and Variability Of Tepsmentioning

confidence: 99%

“…A single TMS pulse evokes a series of time-locked peaks and troughs in electroencephalographic (EEG) recordings of brain activity [2], which are commonly known as TMS-evoked EEG potentials (TEPs). TEPs are reliable within and between sessions [3][4][5], are sensitive to changes in TMS parameters such as intensity [4] and pulse shape [6], and differ depending on the cortical site stimulated [4]. In addition, TEPs are sensitive to changes in cortical properties resulting from differing brain states, plasticity-inducing brain stimulation paradigms, and brain disorders [7].…”

Section: Introductionmentioning

confidence: 99%

TMS-evoked EEG potentials from prefrontal and parietal cortex: reliability, site specificity, and effects of NMDA receptor blockade

Rogasch

Zipser

Darmani

et al. 2018

Preprint

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Measuring the brain's response to transcranial magnetic stimulation (TMS) with electroencephalography (EEG) offers a unique insight into the local cortical circuits and networks activated following stimulation, particularly in non-motor regions where less is known about TMS physiology. However, the mechanisms underlying TMS-evoked EEG potentials (TEPs) remain largely unknown. We assessed TEP reliability, site-specificity, and sensitivity to changes in excitatory neurotransmission mediated by n-methyl-d-aspartate (NMDA) receptors following stimulation of non-motor regions. In fourteen male volunteers, resting EEG and TEPs from prefrontal (PFC) and parietal (PAR) cortex were measured before and after administration of either dextromethorphan (an NMDA receptor antagonist) or placebo across two sessions separated by at least a week in a double-blinded pseudo-randomised crossover design.At baseline, TEPs showed lower within-than between-subject variability for both stimulation sites across sessions, demonstrating the reliability of non-motor TEPs within individuals. There were differences in amplitude between PFC and PAR TEPs across a wide time range (15-250 ms), however the signals were correlated after ~80 ms, suggesting that early peaks reflect sitespecific activity, whereas late peaks reflect activity patterns less dependent on the stimulated sites. TEPs were not altered following dextromethorphan compared to placebo, however low frequency resting oscillations were reduced in power. Our findings suggest that TEPs from PFC and PAR: 1) are reliable within and variable between individuals; 2) reflect stimulation site specific activity across early time periods (<80 ms); and 3) are not sensitive to changes in NMDA receptor-mediated neurotransmission.

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Test-retest reliability of transcranial magnetic stimulation EEG evoked potentials

Cited by 116 publications

References 32 publications

Test–retest reliability of a stimulation‐locked evoked response to deep brain stimulation in subcallosal cingulate for treatment resistant depression

Test–retest reliability of a stimulation‐locked evoked response to deep brain stimulation in subcallosal cingulate for treatment resistant depression

Phase-amplitude markers of synchrony and noise: A resting-state and TMS-EEG study of schizophrenia

TMS-evoked EEG potentials from prefrontal and parietal cortex: reliability, site specificity, and effects of NMDA receptor blockade

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