Test/Retest Reliability of Maximum Mouth Pressure Measurements With the MicroRPM in Healthy Volunteers

Dimitriadis, Zacharias; Kapreli, Eleni; Konstantinidou, Ioanna; Oldham, Jacqueline; Στριμπάκος, Νικόλαος

doi:10.4187/respcare.00783

Cited by 99 publications

(91 citation statements)

References 27 publications

(34 reference statements)

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“…A flanged mouthpiece was used as recommended by the American Thoracic Society/European Respiratory Society (ATS/ERS), because it ensures the least air leakage at the mouthpiece [13]. This method was used, since the portability of the manometer is advantageous for clinical use and its reliability has been assessed [14]. …”

Section: Methodsmentioning

confidence: 99%

Pulmonary function in patients with Huntington’s Disease

et al. 2014

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BackgroundHuntington’s disease (HD) is a neurodegenerative disorder characterized by progressive motor, cognitive and psychiatric disturbances. Chest muscle rigidity, respiratory muscle weakness, difficulty in clearing airway secretions and swallowing abnormalities have been described in patients with neurodegenerative disorders including HD. However limited information is available regarding respiratory function in HD patients. The purpose of this study was to investigate pulmonary function of patients with HD in comparison to healthy volunteers, and its association with motor severity.MethodsPulmonary function measures were taken from 18 (11 male, 7 female) manifest HD patients (53 ± 10 years), and 18 (10 male, 8 female) healthy volunteers (52 ± 11 years) with similar anthropometric and life-style characteristics to the recruited HD patients. Motor severity was quantified by the Unified Huntington’s Disease Rating Scale-Total Motor Score (UHDRS-TMS). Maximum respiratory pressure was measured on 3 separate days with a week interval to assess test-retest reliability.ResultsThe test-retest reliability of maximum inspiratory and expiratory pressure measurements was acceptable for both HD patient and control groups (ICC ≥0.92), but the values over 3 days were more variable in the HD group (CV < 11.1%) than in the control group (CV < 7.6%). The HD group showed lower respiratory pressure, forced vital capacity, peak expiratory flow and maximum voluntary ventilation than the control group (p < 0.05). Forced vital capacity, maximum voluntary ventilation and maximum respiratory pressures were negatively (r = -0.57; -0.71) correlated with the UHDRS-TMS (p < 0.05).ConclusionPulmonary function is decreased in manifest HD patients, and the magnitude of the decrease is associated with motor severity.

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Section: Methodsmentioning

confidence: 99%

Pulmonary function in patients with Huntington’s Disease

et al. 2014

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“…20 This device has been shown to have excellent reliability in measuring MIP in non-ventilated participants (intraclass correlation coefficient 0.83-0.90). 21 Raw MIP scores were normalised using the method described by Evans and Whitelaw 22 and have been presented as percentage of predicted values to account for known variation of MIP with age and gender. Inspiratory muscle fatigue was measured using the fatigue resistance index (FRI) technique described by Chang and colleagues, 3 based on the maximum incremental threshold loading test described in the American Thoracic Society/European Respiratory Society guidelines.…”

Section: Primary Endpointsmentioning

confidence: 99%

Inspiratory muscle training to enhance recovery from mechanical ventilation: a randomised trial

Bissett

Leditschke

Neeman

et al. 2016

Thorax

105

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BackgroundIn patients who have been mechanically ventilated, inspiratory muscles remain weak and fatigable following ventilatory weaning, which may contribute to dyspnoea and limited functional recovery. Inspiratory muscle training may improve inspiratory muscle strength and endurance following weaning, potentially improving dyspnoea and quality of life in this patient group.MethodsWe conducted a randomised trial with assessor-blinding and intention-to-treat analysis. Following 48 hours of successful weaning, 70 participants (mechanically ventilated ≥7 days) were randomised to receive inspiratory muscle training once daily 5 days/week for 2 weeks in addition to usual care, or usual care (control). Primary endpoints were inspiratory muscle strength and fatigue resistance index (FRI) 2 weeks following enrolment. Secondary endpoints included dyspnoea, physical function and quality of life, post-intensive care length of stay and in-hospital mortality.Results34 participants were randomly allocated to the training group and 36 to control. The training group demonstrated greater improvements in inspiratory strength (training: 17%, control: 6%, mean difference: 11%, p=0.02). There were no statistically significant differences in FRI (0.03 vs 0.02, p=0.81), physical function (0.25 vs 0.25, p=0.97) or dyspnoea (−0.5 vs 0.2, p=0.22). Improvement in quality of life was greater in the training group (14% vs 2%, mean difference 12%, p=0.03). In-hospital mortality was higher in the training group (4 vs 0, 12% vs 0%, p=0.051).ConclusionsInspiratory muscle training following successful weaning increases inspiratory muscle strength and quality of life, but we cannot confidently rule out an associated increased risk of in-hospital mortality.Trial registration numberACTRN12610001089022, results.

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“…22 This suggests that at least one previous testing session is necessary to achieve more accurate values. Baseline data showed marked variability between participants in the pulmonary and swallowing function variables (Table 2).…”

Section: Discussionmentioning

confidence: 97%