Test-retest reliability of Diffusion Tensor Imaging metrics in neonates

Merisaari, Harri; Tuulari, Jetro J.; Karlsson, Lena; Scheinin, Noora M.; Parkkola, Riitta; Saunavaara, Jani; Lähdesmäki, Tuire; Lehtola, Satu J.; Keskinen, Maria; Lewis, John D.; Evans, Alan C.; Karlsson, Hasse

doi:10.1016/j.neuroimage.2019.04.067

Cited by 33 publications

(48 citation statements)

References 33 publications

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“…Next, we corrected the data for eddy currents using FSL ( Andersson and Sotiropoulos, 2016 ). Correlation to minor residual motion (after dtiprep) was assessed in our prior work ( Merisaari et al., 2019 ) and they did not bias the estimates. Finally, we processed the 4D diffusion dataset with FSL’s dtifit, using the brain mask to limit the modeling to brain tissue only.…”

Section: Methodsmentioning

confidence: 99%

“…The combined data now included a variable number of diffusion encoding directions, and those containing less than 40 diffusion encoding directions were excluded from later analyses. Finally, directions in excess to 40 were removed, while always maximizing the angular resolution ( Merisaari et al., 2019 ), so that each participant now had exactly 40 diffusion encoding directions in their data. Finally, the 3D distribution of available diffusion encoding directions was assured to be even, as per planned coverage of the sequences and visual inspection of the distributions after preprocessing ( Roalf et al., 2016 ).…”

Section: Methodsmentioning

confidence: 99%

“…A modified version of the ‘tbss_3_postreg -S’ step was then run to incorporate registrations to the study-specific template and up-sample the data to 1 mm 3 resolution as per TBSS defaults. An FA threshold of 0.15 in the ‘tbss_4_prestats’ module was used to create an FA skeleton ( Merisaari et al., 2019 ).…”

Section: Methodsmentioning

confidence: 99%

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Newborn white matter microstructure moderates the association between maternal postpartum depressive symptoms and infant negative reactivity

Nolvi

Tuulari

Lavonius

et al. 2020

Social Cognitive and Affective Neuroscience

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Maternal postpartum depression is a prominent risk factor for aberrant child socioemotional development, but there is little understanding about the neural phenotypes that underlie infant sensitivity to maternal depression. We examined whether newborn white matter fractional anisotropy (FA), a measure of white matter maturity, moderates the association between maternal postpartum depressive symptoms and infant negative reactivity at 6 months. Participants were 80 mother–infant dyads participating in a prospective population-based cohort, and included families whose newborns underwent a magnetic resonance/diffusion tensor imaging scan at 2–5 weeks of age and whose mothers reported their own depressive symptoms at 3 and 6 months postpartum and infant negative emotional reactivity at 6 months. The whole-brain FA moderated the association between maternal depressive symptoms and mother-reported infant negative reactivity at 6 months after adjusting for the covariates. Maternal depressive symptoms were positively related to infant negative reactivity among infants with high or average FA in the whole brain and in corpus callosum and cingulum, but not among those with low FA. The link between maternal depressive symptoms and infant negative reactivity was moderated by newborn FA. The variation in white matter microstructure might play a role in child susceptibility to parental distress.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Newborn white matter microstructure moderates the association between maternal postpartum depressive symptoms and infant negative reactivity

Nolvi

Tuulari

Lavonius

et al. 2020

Social Cognitive and Affective Neuroscience

Self Cite

View full text Add to dashboard Cite

show abstract

“…Diffusion tensor imaging (DTI) data from brain MRI were obtained to determine the effects of treatment on the white matter integration. Fractional anisotropy (FA) values were calculated by a voxel-based approach using the Tract-Based Spatial Statistics tool in an automated process [46,47]. There are a total of 17 different white-mater tracts-single corpus callosum and bilateral fibers of eight tracts such as the anterior thalamic radiation (ATR), the cingulum in the cingulate cortex area, the cingulum in the hippocampal area, the corticospinal tract, the inferior fronto-occipital fasciculus, the superior and the inferior longitudinal fasciculus, and the uncinate fasciculus (Additional file 3)from JHU white matter tractography atlases [48].…”

Section: Imaging Studies and Electroencephalogram (Eeg)mentioning

confidence: 99%

Potentiation of cord blood cell therapy with erythropoietin for children with CP: a 2 × 2 factorial randomized placebo-controlled trial

et al. 2020

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Background Concomitant administration of allogeneic umbilical cord blood (UCB) infusion and erythropoietin (EPO) showed therapeutic efficacy in children with cerebral palsy (CP). However, no clinical studies have investigated the effects of UCB and EPO combination therapy using a 2 × 2 four-arm factorial blinded design with four arms. This randomized placebo-controlled trial aimed to identify the synergistic and individual efficacies of UCB cell and EPO for the treatment of CP. Methods Children diagnosed with CP were randomly segregated into four groups: (A) UCB+EPO, (B) UCB+placebo EPO, (C) placebo UCB+EPO, and (D) placebo UCB+placebo EPO. Based on the UCB unit selection criteria of matching for ≥ 4/6 of human leukocyte antigen (HLA)-A, -B, and DRB1 and total nucleated cell (TNC) number of ≥ 3 × 107/kg, allogeneic UCB was intravenously infused and 500 IU/kg human recombinant EPO was administered six times. Functional measurements, brain imaging studies, and electroencephalography were performed from baseline until 12 months post-treatment. Furthermore, adverse events were closely monitored. Results Eighty-eight of 92 children enrolled (3.05 ± 1.22 years) completed the study. Change in gross motor performance measure (GMPM) was greater in group A than in group D at 1 month (△2.30 vs. △0.71, P = 0.025) and 12 months (△6.85 vs. △2.34, P = 0.018) post-treatment. GMPM change ratios were calculated to adjust motor function at the baseline. Group A showed a larger improvement in the GMPM change ratio at 1 month and 12 months post-treatment than group D. At 12 months post-treatment, the GMPM change ratios were in the order of groups A, B, C, and D. These results indicate synergistic effect of UCB and EPO combination better than each single therapy. In diffusion tensor imaging, the change ratio of fractional anisotropy at spinothalamic radiation was higher in group A than group D in subgroup of age ≥ 3 years. Additionally, higher TNC and more HLA-matched UCB units led to better gross motor outcomes in group A. Adverse events remained unchanged upon UCB or EPO administration. Conclusions These results indicate that the efficacy of allogeneic UCB cell could be potentiated by EPO for neurological recovery in children with CP without harmful effects. Trial registration ClinicalTrials.gov, NCT01991145, registered 25 November 2013.

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“…The intraclass correlation (ICC) was also used to evaluate the reliability of the entropy calculation of each functional network by comparing the variability of entropy of the two scans of the same subject to the total variation across all subjects (for resting state and for task performing) using a Microsoft Excel Add-in to calculate ICC (3,1) (Merisaari et al, 2019).…”

Section: Paired T-test and Reliability Evaluationmentioning

confidence: 99%

Functional MRI Signal Complexity Analysis Using Sample Entropy

2020

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Resting-state functional magnetic resonance imaging (rs-fMRI) is an immensely powerful method in neuroscience that uses the blood oxygenation level-dependent (BOLD) signal to record and analyze neural activity in the brain. We examined the complexity of brain activity acquired by rs-fMRI to determine whether it exhibits variation across brain regions. In this study the complexity of regional brain activity was analyzed by calculating the sample entropy of 200 whole-brain BOLD volumes as well as of distinct brain networks, cortical regions, and subcortical regions of these brain volumes. It can be seen that different brain regions and networks exhibit distinctly different levels of entropy/complexity, and that entropy in the brain significantly differs between brains at rest and during task performance.

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Test-retest reliability of Diffusion Tensor Imaging metrics in neonates

Cited by 33 publications

References 33 publications

Newborn white matter microstructure moderates the association between maternal postpartum depressive symptoms and infant negative reactivity

Newborn white matter microstructure moderates the association between maternal postpartum depressive symptoms and infant negative reactivity

Potentiation of cord blood cell therapy with erythropoietin for children with CP: a 2 × 2 factorial randomized placebo-controlled trial

Functional MRI Signal Complexity Analysis Using Sample Entropy

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