Test-Retest Reliability of an Adaptive Thermal Pain Calibration Procedure in Healthy Volunteers

Amir, Carolyn; Rose-McCandlish, Margaret; Weger, Rachel; Dildine, Troy C.; Mischkowski, Dominik; Necka, Elizabeth A.; Lee, In Seon; Wager, Tor D.; Pine, Daniel S.; Atlas, Lauren Y.

doi:10.1016/j.jpain.2022.01.011

Cited by 11 publications

(3 citation statements)

References 79 publications

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“…The first one is based on R 2 where high values indicate good data linearity. A recent study on thermal stimulation (Amir et al., 2022) established that for a successful calibration procedure, R 2 should be at least .4. The second is related to the convergence of the parameters.…”

Section: Discussionmentioning

confidence: 99%

“…To further improve the proposed calibration reliability, a random strength stimulation verification of reliability should be performed a posteriori . This could be used to check if the calibration results are consistent over time, as was done before for thermal stimulation (Amir et al., 2022). Afterward, it is recommended to compare our method to the results obtained using the random staircase procedure.…”

Section: Discussionmentioning

confidence: 99%

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How to make calibration less painful—A proposition for an automatic, reliable and time‐efficient procedure

Świder,

Moratti,

Bruña

2024

Psychophysiology

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In behavioral and neurophysiological pain studies, multiple types of calibration methods are used to quantify the individual pain sensation stimuli. Often, studies lack a detailed calibration procedure description, data linearity, and quality quantification and omit required control for sex pain differences. This hampers study repetition and interexperimental comparisons. Moreover, typical calibration procedures require a high number of stimulations, which may cause discomfort and stimuli habituation among participants. To overcome those shortcomings, we present an automatic calibration procedure with a novel stimuli estimation method for intraepidermal stimulation. We provide an in‐depth data analysis of the collected self‐reports from 70 healthy volunteers (37 males) and propose a method based on a dynamic truncated linear regression model (tLRM). We compare its estimates for the sensation (t) and pain (T) thresholds and mid‐pain stimulation (MP), with those calculated using traditional estimation methods and standard linear regression models. Compared to the other methods, tLRM exhibits higher R2 and requires 36% fewer stimuli applications and has significantly higher t intensity and lower T and MP intensities. Regarding sex differences, t and T were found to be lower for females compared to males, regardless of the estimation method. The proposed tLRM method quantifies the calibration procedure quality, minimizes its duration and invasiveness, and provides validation of linearity between stimuli intensity and subjective scores, making it an enabling technique for further studies. Moreover, our results highlight the importance of control for sex in pain studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

How to make calibration less painful—A proposition for an automatic, reliable and time‐efficient procedure

Świder,

Moratti,

Bruña

2024

Psychophysiology

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“…First, sensory detection reports may depend heavily on context, including experience prior to each session. Context-dependent sensitivity is known to be important in sensations at noxious temperatures, 36,37 but may also apply also to the non-noxious temperatures studied here. Second, fluctuations of peripheral excitability across time may also play a major role in thermoception.…”

mentioning

confidence: 84%

Revisiting a classical theory of sensory specificity: assessing consistency and stability of thermosensitive spots

Ezquerra-Romano¹,

Clements

Costa³

et al. 2023

Preprint

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Thermal sensitivity is not uniform across the skin, and is particularly high in small (~1mm2) regions termed 'thermosensitive spots'. These spots are thought to reflect the anatomical location of specialised thermosensitive nerve endings from single primary afferents. Thermosensitive spots provide foundational support for 'labelled line' or specificity theory of sensory perception, which state that different sensory qualities are transmitted by separate and specific neural pathways. This theory predicts a highly stable relation between repetitions of a thermal stimulus and the resulting sensory quality, yet these predictions have rarely been tested systematically. Here we present the qualitative, spatial and repeatability properties of 334 thermosensitive spots on the dorsal forearm sampled across 4 separate sessions. In line with previous literature, we found that spots associated with cold sensations (112 cold spots, 34%) were more frequent than spots associated with warm sensations (41 warm spots, 12%). Still more frequent (165 spots, 49%) were spots that elicited inconsistent sensations when repeatedly stimulated by the same temperature. Remarkably, only 13 spots (4%) conserved their position between sessions. Overall, we show unexpected inconsistency of both the perceptual responses elicited by spot stimulation and of spot locations across time. These observations challenge the traditional view that thermosensitive spots reflect the location of individual thermosensitive primary afferents serving as specific labelled lines for corresponding sensory qualities.

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Test–retest and inter‐rater reliability of two devices measuring tactile mechanical detection thresholds in healthy adults: Semmes–Weinstein monofilaments and the cutaneous mechanical stimulator

Mamino,

Lithfous,

Pebayle

et al. 2024

Muscle and Nerve

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Introduction/AimsLimitations exist in evaluating mechanical detection thresholds (MDTs) due to a lack of dependable electronic instruments designed to assess Aβ fibers and measure MDTs across different body areas. This study aims to evaluate the test–retest and inter‐rater reliability of the cutaneous mechanical stimulator (CMS), an electronic tactile stimulator, in quantifying MDTs.MethodsUsing a test–retest design, participants underwent assessments of MDTs using Semmes–Weinstein monofilaments (SWM) and the CMS. This study included 27 healthy volunteers (mean age 24.07 ± 3.76 years). Two raters assessed MDTs using SWM and the CMS at two stimulation sites (the left hand and foot) in two experimental sessions approximately 2 weeks apart.ResultsMDTs using SWM and the CMS showed excellent reliability on the hand (intraclass correlation coefficient [ICC] = .84) and foot (ICC = .90). A comparison of results obtained at the two sessions showed that MDTs on the hand displayed good reliability for both SWM (ICC = .63) and the CMS (ICC = .73), whereas MDTs on the foot displayed fair reliability for SWM (ICC = .50) and the CMS (ICC = .42). MDTs exhibited good inter‐rater reliability with SWM (ICC = .66) and excellent inter‐rater reliability with the CMS (ICC = .82) on the hand, as well as showing fair inter‐rater reliability with SWM (ICC = .53) and good inter‐rater reliability with the CMS (ICC = .60) on the foot.DiscussionThe CMS showed superior inter‐rater reliability, indicating its potential as a valuable tool for assessing tactile sensitivity in research and clinical settings.

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Test-Retest Reliability of an Adaptive Thermal Pain Calibration Procedure in Healthy Volunteers

Cited by 11 publications

References 79 publications

How to make calibration less painful—A proposition for an automatic, reliable and time‐efficient procedure

How to make calibration less painful—A proposition for an automatic, reliable and time‐efficient procedure

Revisiting a classical theory of sensory specificity: assessing consistency and stability of thermosensitive spots

Test–retest and inter‐rater reliability of two devices measuring tactile mechanical detection thresholds in healthy adults: Semmes–Weinstein monofilaments and the cutaneous mechanical stimulator

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