Test-retest reliability and reproducibility of long-label pseudo-continuous arterial spin labeling

Lin, Tianye; Qu, Jianxun; Zuo, Zhentao; Fan, Xiaoyuan; You, Hui; Feng, Feng

doi:10.1016/j.mri.2020.07.010

Cited by 16 publications

(19 citation statements)

References 24 publications

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“…This software processes pcASL data in a standardized one-click mode. The same model used for CBF calculation was based on a previous study (Williams et al, 1992 ; Lin et al, 2020 ). Data were preprocessed using SPM12 (Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom) implemented on MATLAB (MathWorks, Natick, MA, United States).…”

Section: Methodsmentioning

confidence: 99%

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The Association Between Perivascular Spaces and Cerebral Blood Flow, Brain Volume, and Cardiovascular Risk

Liu

Hou

You

et al. 2021

Front. Aging Neurosci.

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Background: Basal ganglia perivascular spaces are associated with cognitive decline and cardiovascular risk factors. There is a lack of studies on the cardiovascular risk burden of basal ganglia perivascular spaces (BG-PVS) and their relationship with gray matter volume (GMV) and GM cerebral blood flow (CBF) in the aging brain. Here, we investigated these two issues in a large sample of cognitively intact older adults.Methods: A total of 734 volunteers were recruited. MRI was performed with 3.0 T using a pseudo-continuous arterial spin labeling (pCASL) sequence and a sagittal isotropic T1-weighted sequence for CBF and GMV analysis. The images obtained from 406 participants were analyzed to investigate the relationship between the severity of BG-PVS and GMV/CBF. False discovery rate-corrected P-values (PFDR) of <0.05 were considered significant. The images obtained from 254 participants were used to study the relationship between the severity of BG-PVS and cardiovascular risk burden. BG-PVS were rated using a 5-grade score. The severity of BG-PVS was classified as mild (grade <3) and severe (grade ≥3). Cardiovascular risk burden was assessed with the Framingham General Cardiovascular Risk Score (FGCRS).Results: Severe basal ganglia perivascular spaces were associated with significantly smaller GMV and CBF in multiple cortical regions (PFDR <0.05), and were associated with significantly larger volume in the bilateral caudate nucleus, pallidum, and putamen (PFDR <0.05). The participants with severe BG-PVS were more likely to have a higher cardiovascular risk burden than the participants with mild BG-PVS (60.71% vs. 42.93%; P =0.02).Conclusion: In cognitively intact older adults, severe BG-PVS are associated with smaller cortical GMV and CBF, larger subcortical GMV, and higher cardiovascular risk burden.

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Section: Methodsmentioning

confidence: 99%

“…This software processes pcASL data in a standardized one-click mode. The same model used for CBF calculation was based on a previous study (Williams et al, 1992;Lin et al, 2020 Natick, MA, United States). First, the CBF maps were coregistered to 3D T1-weighted images.…”

Section: Asl Data Processmentioning

confidence: 99%

The Association Between Perivascular Spaces and Cerebral Blood Flow, Brain Volume, and Cardiovascular Risk

Liu

Hou

You

et al. 2021

Front. Aging Neurosci.

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“…96 Multiple studies have demonstrated good feasibility, applicability and reproducibility of ASL in geriatric populations. 71,97 The clinical application of 'classical' ASL imaging is still limited though.…”

Section: Recent Technical Advances Expanding the Clinical Use Of Asl ...mentioning

confidence: 99%

Recent advances in arterial spin labeling perfusion MRI in patients with vascular cognitive impairment

Huang

Guo

Guan

et al. 2022

J Cereb Blood Flow Metab

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Cognitive impairment (CI) is a major health concern in aging populations. It impairs patients’ independent life and may progress to dementia. Vascular cognitive impairment (VCI) encompasses all cerebrovascular pathologies that contribute to cognitive impairment (CI). Moreover, the majority of CI subtypes involve various aspects of vascular dysfunction. Recent research highlights the critical role of reduced cerebral blood flow (CBF) in the progress of VCI, and the detection of altered CBF may help to detect or even predict the onset of VCI. Arterial spin labeling (ASL) is a non-invasive, non-ionizing perfusion MRI technique for assessing CBF qualitatively and quantitatively. Recent methodological advances enabling improved signal-to-noise ratio (SNR) and data acquisition have led to an increase in the use of ASL to assess CBF in VCI patients. Combined with other imaging modalities and biomarkers, ASL has great potential for identifying early VCI and guiding prediction and prevention strategies. This review focuses on recent advances in ASL-based perfusion MRI for identifying patients at high risk of VCI.

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“…Betweensubjects, the pCASL CBF measurements in the post-surgical pain state and CBF were both characterized as moderately reliable (ICC > 0.4) across nine ROIs. Lin et al (2020) compared test-retest repeatability of 3D pCASL with standard (1,500 ms) and long (3,500 ms) labeling duration in 20 adult volunteers (age 56.6 ± 17.2 years) with a 1 h interval. The ICCs were generally high (> 0.85) and wsCV < 10% across lobar ROIs with the long labeling duration pCASL showing higher repeatability.…”

Section: Test-retest Repeatability Of Cbfmentioning

confidence: 99%

Evaluation of Cerebral Blood Flow Measured by 3D PCASL as Biomarker of Vascular Cognitive Impairment and Dementia (VCID) in a Cohort of Elderly Latinx Subjects at Risk of Small Vessel Disease

et al. 2021

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Cerebral small vessel disease (cSVD) affects arterioles, capillaries, and venules and can lead to cognitive impairments and clinical symptomatology of vascular cognitive impairment and dementia (VCID). VCID symptoms are similar to Alzheimer’s disease (AD) but the neurophysiologic alterations are less well studied, resulting in no established biomarkers. The purpose of this study was to evaluate cerebral blood flow (CBF) measured by 3D pseudo-continuous arterial spin labeling (pCASL) as a potential biomarker of VCID in a cohort of elderly Latinx subjects at risk of cSVD. Forty-five elderly Latinx subjects (12 males, 69 ± 7 years) underwent repeated MRI scans ∼6 weeks apart. CBF was measured using 3D pCASL in the whole brain, white matter and 4 main vascular territories (leptomeningeal anterior, middle, and posterior cerebral artery (leptoACA, leptoMCA, leptoPCA), as well as MCA perforator). The test-retest repeatability of CBF was assessed by intra-class correlation coefficient (ICC) and within-subject coefficient of variation (wsCV). Absolute and relative CBF was correlated with gross cognitive measures and domain specific assessment of executive and memory function, vascular risks, and Fazekas scores and volumes of white matter hyperintensity (WMH). Neurocognitive evaluations were performed using Montreal Cognitive Assessment (MoCA) and neuropsychological test battery in the Uniform Data Set v3 (UDS3). Good to excellent test-retest repeatability was achieved (ICC = 0.77–0.85, wsCV 3–9%) for CBF measurements in the whole brain, white matter, and 4 vascular territories. Relative CBF normalized by global mean CBF in the leptoMCA territory was positively correlated with the executive function composite score, while relative CBF in the leptoMCA and MCA perforator territory was positively correlated with MoCA scores, controlling for age, gender, years of education, and testing language. Relative CBF in WM was negatively correlated with WMH volume and MoCA scores, while relative leptoMCA CBF was positively correlated with WMH volume. Reliable 3D pCASL CBF measurements were achieved in the cohort of elderly Latinx subjects. Relative CBF in the leptomeningeal and perforator MCA territories were the most likely candidate biomarker of VCID. These findings need to be replicated in larger cohorts with greater variability of stages of cSVD.

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Test-retest reliability and reproducibility of long-label pseudo-continuous arterial spin labeling

Cited by 16 publications

References 24 publications

The Association Between Perivascular Spaces and Cerebral Blood Flow, Brain Volume, and Cardiovascular Risk

The Association Between Perivascular Spaces and Cerebral Blood Flow, Brain Volume, and Cardiovascular Risk

Recent advances in arterial spin labeling perfusion MRI in patients with vascular cognitive impairment

Evaluation of Cerebral Blood Flow Measured by 3D PCASL as Biomarker of Vascular Cognitive Impairment and Dementia (VCID) in a Cohort of Elderly Latinx Subjects at Risk of Small Vessel Disease

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