Test–retest reliability and longitudinal analysis of automated hippocampal subregion volumes in healthy ageing and<scp>A</scp>lzheimer's disease populations

Worker, Amanda; Dima, Danai; Combes, Anna J.E.; Crum, William R.; Streffer, Johannes; Einstein, Steven; Mehta, Mitul A.; Barker, Gareth J.; Williams, Steven; O’Daly, Owen

doi:10.1002/hbm.23948

Cited by 44 publications

(42 citation statements)

References 43 publications

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“…Also, the use of novel neuroimaging automated pipelines to accurately segment the hippocampus to investigate regional vulnerability. FreeSurfer’s pipeline is based on ex vivo 7T images to manually segment the hippocampus in order to create the statistical atlas; and it has been recently proved to have a good test-retest reliability over time (Worker et al, 2018 ). However, the authors (Iglesias et al, 2015 ) recommend caution on the interpretation of results involving the internal subfields such as the CA4, molecular layer or the Granule cells in the molecular layer of the DG.…”

Section: Discussionmentioning

confidence: 99%

Differential Progression of Regional Hippocampal Atrophy in Aging and Parkinson’s Disease

Uribe

Segura

Baggio

et al. 2018

Front. Aging Neurosci.

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Hippocampal subfields have different vulnerability to the degenerative processes related to aging, amnestic mild cognitive impairment (MCI) and Alzheimer’s disease (AD), but the temporal evolution in Parkinson’s disease (PD) is unknown. The purposes of the current work are to describe regional hippocampal changes over time in a sample of PD patients classified according to their baseline cognitive status and to relate these changes to verbal memory loss. T1-weighted images and verbal memory assessment were obtained at two separate time points (3.8 ± 0.4 years apart) from 28 PD with normal cognition (PD-NC), 16 PD with MCI (PD-MCI) and 21 healthy controls (HCs). FreeSurfer 6.0 automated pipeline was used to segment the hippocampus into 12 bilateral subregions. Memory functions were measured with Rey’s Auditory Verbal learning test (RAVLT). We found significant reductions in cornu ammonis 1 (CA1) over time in controls as well as in PD subgroups. Right whole-hippocampal volumes showed time effects in both PD groups but not in controls. PD-NC patients also displayed time effects in the left hippocampal tail and right parasubiculum. Regression analyses showed that specific hippocampal subfield volumes at time 1 predicted almost 60% of the variability in RAVLT delayed-recall score decline. Changes in several hippocampal subregions also showed predictive value for memory loss. In conclusion, CA1 changes in PD were similar to those that occur in normal aging, but PD patients also had more decline in both anterior and posterior hippocampal segments with a more pronounced atrophy of the right hemisphere. Hippocampal segments are better predictors of changes in memory performance than whole-hippocampal volumes.

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Section: Discussionmentioning

confidence: 99%

Differential Progression of Regional Hippocampal Atrophy in Aging and Parkinson’s Disease

Uribe

Segura

Baggio

et al. 2018

Front. Aging Neurosci.

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“…Next, using the outputs from FS6.0‐hsf, images were further processed using the subfield‐specific atlases for the amygdala and thalamus . The segmentation pipeline uses a probabilistic atlas to estimate hippocampal, amygdalar and thalamus subfields with a Bayesian Inference algorithm that automatically adapts to the MRI image intensity of each scanner machine …”

Section: Methodsmentioning

confidence: 99%

Aberrant limbic brain structures in young individuals at risk for mental illness

Nogovitsyn

Souza

Muller

et al. 2020

Psychiatry Clin Neurosci

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Aim Alterations in limbic structures may be present before the onset of serious mental illness, but whether subfield‐specific limbic brain changes parallel stages in clinical risk is unknown. To address this gap, we compared the hippocampus, amygdala, and thalamus subfield‐specific volumes in adolescents at various stages of risk for mental illness. Methods MRI scans were obtained from 182 participants (aged 12–25 years) from the Canadian Psychiatric Risk and Outcome study. The sample comprised of four groups: asymptomatic youth at risk due to family history of mental illness (Stage 0, n = 32); youth with early symptoms of distress (Stage 1a, n = 41); youth with subthreshold psychotic symptoms (Stage 1b, n = 72); and healthy comparison participants with no family history of serious mental illness (n = 37). Analyses included between‐group comparisons of brain measurements and correlational analyses that aimed to identify significant associations between neuroimaging and clinical measurements. A machine‐learning technique examined the discriminative properties of the clinical staging model. Results Subfield‐specific limbic volume deficits were detected at every stage of risk for mental illness. A machine‐learning classifier identified volume deficits within the body of the hippocampus, left amygdala nuclei, and medial‐lateral nuclei of the thalamus that were most informative in differentiating between risk stages. Conclusion Aberrant subfield‐specific changes within the limbic system may serve as biological evidence to support transdiagnostic clinical staging in mental illness. Differential patterns of volume deficits characterize those at risk for mental illness and may be indicative of a risk‐stage progression.

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“…In addition, the approach was validated in an independent in vivo 1 mm MRI resolution data-set of 39 individuals, and was shown to be superior to its predecessor (FreeSurfer v.5.0.3) that was based on in-vivo data only. FreeSurfer v6.0 further has a high reliability (intraclass correlation coefficient = 0.9 or higher for subfields CA1, CA3, DG, subiculum, and other), which is also superior to the previous version of Freesurfer 56 . Identification of hippocampal subfields using FreeSurfer 6.0 should be considered probabilistic, as it uses prior knowledge from ex vivo brains scanned at 7 T MRI combined with the available contrast information from MR images (Iglesias, et al, 2015).…”

Section: Resultsmentioning

confidence: 95%

Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study

Riphagen

Schmiedek

Gronenschild

et al. 2020

Sci Rep

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Pattern separation (PS) describes the process by which the brain discriminates similar stimuli from previously encoded stimuli. This fundamental process requires the intact processing by specific subfields in the hippocampus and can be examined using mnemonic discrimination tasks. Previous studies reported different patterns for younger and older individuals between mnemonic discrimination performance and hippocampal subfield activation. Here, we investigated the relationship between the lure discrimination index (LDI) and hippocampal subfield volume and activity across the adult lifespan (20-70 years old). Using ultra-high field functional and structural magnetic resonance imaging at 7 T, we found that lower DG volume and higher CA3 activation was associated with worse LDI performance in individuals (>60 years), suggesting that this higher activation may be an indication of aberrant neurodegenerative-related processes. In fact, higher activation in the CA1 and DG was associated with lower volumes in these subfields. For individuals around 40-50 years old, we observed that greater left and right DG volume, and greater activity in the CA3 was associated with lower LDI performance. Taken together, these results suggest that the relationship between memory and hippocampal subfield structure or function varies nonlinearly and possibly reciprocally with age, with midlife being a critically vulnerable period in life. A decline in cognitive functions is part of normal ageing 1 and for older adults, memory problems, in particular in episodic memory, are considered among the most worrisome. The hippocampus is known to play a central role in episodic memory 2,3. The hippocampus is not a homogeneous structure, different subfields are involved in different memory processes 4. This has in particular been shown for pattern separation and completion, the most extensively investigated memory processes in the context of distinct hippocampal subfield affinities. Pattern separation, the ability to form distinct, non-overlapping representations from similar or overlapping inputs has been shown to rely on the dentate gyrus (DG) and Cornu Ammonis (CA3) regions in human studies 5-10. A distinction is made between behavioural pattern separation of objects and of spatial locations 4. While the downstream pathways for spatial pattern separation involve medial entorhinal cortices, object pattern separation engages the lateral entorhinal cortices. In the hippocampal subfields CA3/DG the distinction between object and spatial pattern separation is no longer present 11. Both variants of pattern separation (object and spatial) are similarly affected by age. Age-related changes in pattern separation have been documented extensively in animal 12 and human studies 4,13. Atrophy of the DG in rodent models of ageing correlated with discrimination deficits 14. Behavioural work demonstrated a monotonic decline in discrimination abilities starting in the fourth decade in

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Test–retest reliability and longitudinal analysis of automated hippocampal subregion volumes in healthy ageing andAlzheimer's disease populations

Cited by 44 publications

References 43 publications

Differential Progression of Regional Hippocampal Atrophy in Aging and Parkinson’s Disease

Differential Progression of Regional Hippocampal Atrophy in Aging and Parkinson’s Disease

Aberrant limbic brain structures in young individuals at risk for mental illness

Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study

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