Test method for evaluation of loss of prime in metered-dose aerosols

Comparative assessment of safety and efficacy of inhaled corticosteroids: report of a committee of the Canadian Thoracic Society

“…2) Failure to shake the pMDI between each puff can materially reduce the amount of drug expelled from the pressurized canister [16]. 3) Variations in the timelapse between expelling the drug and the start of inspiration [17][18][19][20].…”