Test and teach Number Ninety-Three: Part 1

Chuah, Khoon Leong; Tan, Puay Hoon; Chong, Yap Yee

doi:10.1080/003130299104990

Cited by 4 publications

(7 citation statements)

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“…Bereits Ende der 90er Jahre des letzten Jahrhunderts berichteten einzelne Autoren ü ber positive Auswirkung einer Therapie mit dem radioaktiv markierten Somatostatinanalogon 111 In-Octreotid und mit 131 I-Metaiodobenzylguanidin ( 131 I-MIBG) bei Patienten mit multilokul ä r metastasierten paraganglion ä ren Tumo ren [137,138] . Bei Paragangliompatienten, deren Tumoren und Metastasen in der 68 Ga-DOTATATE-PET anreichern (vergleiche • ▶ Abb. 4 ), wird in den letzten Jahren in einzelnen Zentren eine palliative Therapie mit 177 LU-DOTATATE durchgef ü hrt.…”

Section: Stellenwert Der Pr ä Operativen Embolisationunclassified

Paragangliome und Paragangliomsyndrome

Boedeker

2011

Laryngo-Rhino-Otol

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Paragangliomas are rare tumors of neural crest origin. They are benign in the majority of cases and are characterized by a strong vascularisation. In the head and neck region they most commonly occur as carotid body tumors. Jugulotympanic and especially vagal paragangliomas are seen less frequently. Complete surgical resection represents the only curative treatment option even though resection of locally advanced tumors regularly results in lesions of the lower cranial nerves and major vessels. Approximately 30% of all head and neck paragangliomas (HNPs) are hereditary and associated with different tumor syndromes. The paraganglioma syndromes 1, 3 and 4 (PGL 1, 3 and 4) make up the majority of those familial cases. PGL 1 is associated with mutations of the succinate dehydrogenase subunit D (SDHD) gene, PGL 3 is caused by SDHC and PGL 4 by SDHB gene mutations. Multiple HNPs and the occurrence of HNPs together with pheochromocytomas are seen in SDHD as well as SDHB mutation carriers. In patients with SDHB mutations the risk for the development of malignant paraganglial tumors is significantly higher compared to SDHC and SDHD patients as well as patients with sporadic tumors. SDHC mutation carriers almost exclusively present with benign HNPs that are unifocal in the majority of cases. The role of transmission is autosomal dominant for all 3 symptoms. Interestingly, there is a "parent-of-origin-dependent-inheritance" in subjects with SDHD gene mutations. This means that the disease phenotype may only become present if the mutation is inherited through the paternal line. We recommend screening for mutations of the genes SDHB, SDHC and SDHD in all patients with HNPs. Certain clinical parameters can help to set up the order in which the 3 genes should be tested.

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Section: Stellenwert Der Pr ä Operativen Embolisationunclassified

Paragangliome und Paragangliomsyndrome

Boedeker

2011

Laryngo-Rhino-Otol

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“…HNPs as well as pheochromocytomas are basically composed of two cell types: chief cells and sustentacular cells [6], [68], [69], [70], [71]. The histological aspect of the tumor is the typical „Zellballen“ pattern where nests or cords of chief cells are surrounded by sustentacular cells (Figure 6 (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…7)), and neuron specific enolase (Figure 8 (Fig. 8)) [68], [69], [74], [80]. Sustentacular cells are positive for the S-100 protein (Figure 9 (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless they regard FNA as an important tool for the pre-therapeutic diagnosis of HNPs. On the other hand, aspirates from CBTs have been mistaken for many different neoplasms including neurofibroma, neurofibrosarcoma, malignant melanoma, different forms of thyroid cancer as well as metastases from a carcinoma [68]. In addition to the questionable diagnostic value of a FNA in HNPs one has to consider potential side effects such as heavy bleeding [68].…”

Section: Discussionmentioning

confidence: 99%

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Paragangliomas and paraganglioma syndromes

Boedeker

2011

GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 10:Doc03; ISSN 1865-1011

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“…Similar anatomical distribution (often in the carotid space) and non-specific symptomatology makes clinical differentiation of paragangliomas from other neck lesions challenging [ [1] , [2] , [3] ]. Percutaneous biopsy from paragangliomas can often mimic a wide range of benign and malignant head neck [ [4] , [5] , [6] ] pathologies. Further, the additional risks of adrenergic crisis [ 7 , 8 ] and bleeding from the hyper-vascular tumour makes preoperative biopsy of paragangliomas’ difficult [ 5 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Texture analysis of routine T2 weighted fat-saturated images can identify head and neck paragangliomas – A pilot study

Ghosh

Malla

Bhalla

et al. 2020

European Journal of Radiology Open

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Highlights Paragangliomas often undergo contrast-enhanced MRI to establish diagnosis. Nuclear scan are however often required to evaluate multifocality. Texture analysis of T2W sequence can identify paragangliomas with high accuracy. Texture analysis may direct such patients for a nuclear scan without additional contrast study.

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Test and teach Number Ninety-Three: Part 1

Cited by 4 publications

References 0 publications

Paragangliome und Paragangliomsyndrome

Paragangliome und Paragangliomsyndrome

Paragangliomas and paraganglioma syndromes

Texture analysis of routine T2 weighted fat-saturated images can identify head and neck paragangliomas – A pilot study

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