tert-Butylamine functionalized MCM-41 mesoporous nanoparticles as drug carriers for the controlled release of cyclophosphamide anticancer drug

Shariatinia‬, Zahra; Pourzadi, Negar; Darvishi, Seyed Mahmood Rezaei

doi:10.1016/j.surfin.2020.100842

Cited by 17 publications

(5 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The small angle XRD pattern (see Figure 6A) indicates 2D pore packing (hexagonal with planes 100, 110, 200, and 210 noticed at 2θ angles such as 2.42°, 4.02°, 4.63°, and 6.05°with dvalues of 2.25, 1.24, 1.19, and 0.79, respectively), which are typical mesoporous silica characteristics. These pore packings are similar to the reported MCM-41 49 types of mesoporous silica nanoparticles. Among the wide angle XRD patterns of the engineered nanohybrid, the different diffraction planes (111,200,220,311, and 222 at 38.2°, 44.3°, 64.6°, 77.6°, and 81.6°, respectively) ensured the presence of Au nanorods in MS as stacked in Figure S5.…”

Section: ■ Results and Discussionsupporting

confidence: 85%

“…34−47 For achieving MCM-41 types of mesoporous silica nanoparticles, a base-catalyzed (sodium hydroxide, 2 M, 3.5 mL) sol−gel route at high temperature (70− 80 °C) using CTAB surfactant (1 g in 480 mL of aqueous medium) has been widely tried. 48,49 Similar conditions of the MCM-41 protocol have been adopted for effective distribution of gold nanorods in ordered thick mesoporous silica, as discussed below in detail. Reports suggest that the silica layer thickness over gold nanorods can be controlled (13−30 nm) with respect to CTAB concentration.…”

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effective Distribution of Gold Nanorods in Ordered Thick Mesoporous Silica: A Choice of Noninvasive Theranostics

Prasad,

Selvaraj

2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Porous silica coated gold nanorod core−shell structures demonstrate a multifunctional role in bioimaging, drug delivery, and cancer therapeutics applications. Here, we address a new approach for effective distribution of gold nanorods (GNRs) in a mesoporous silica (MS) shell, viz., one nanorod in one silica particle (GMS). We have studied that silica coating presents major advantages for the better biocompatibility and stability of GNRs. In this study, two different thicknesses of silica shell over GNRs have been discussed as per the application's need; GNRs in thin silica (11 nm) are fit for phototherapy and bioimaging, whereas thick and porous silica (51 nm) coated gold nanorods are suitable for triggered drug delivery and theranostics. However, effective distribution of GNRs in ordered architecture of thick mesoporous silica (MS, more than 50 nm thickness) with high surface area (more than 1000 m 2 /g) is not well understood so far. Here, we present methodical investigations for uniform and highly ordered mesoporous silica coating over GNRs with tunable thickness (6 to 51 nm). Judicious identification and optimization of different reaction parameters like concentrations of silica precursor (TEOS, 1.85−43.9 mM), template (CTAB, 0.9−5.7 mM), effect of temperature, pH (8.6−10.8), stirring speed (100−400 rpm), and, most importantly, the mode of addition of TEOS with GNRs have been discussed. Studies with thick, porous silica coated GNRs simplify the highest ever reported surface area (1100 m 2 /g) and cargo capacity (57%) with better product yield (g/batch). First and foremost, we report a highly scalable (more than 500 mL) and rapid direct deposition of an ordered MS shell around GNRs. These engineered core−shell nanoparticles demonstrate X-ray contrast property, synergistic photothermal-chemotherapeutics, and imaging of tumor cell (96% cell death) due to released fluorescent anticancer drug molecules and photothermal effect (52 °C) of embedded GNRs. A deeper insight into their influence on the architectural features and superior theranostics performances has been illustrated in detail. Hence, these findings indicate the potential impact of individual GMS for image guided combination therapeutics of cancer.

show abstract

Section: ■ Results and Discussionsupporting

confidence: 85%

Section: ■ Introductionmentioning

confidence: 99%

Effective Distribution of Gold Nanorods in Ordered Thick Mesoporous Silica: A Choice of Noninvasive Theranostics

Prasad,

Selvaraj

2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…Release Kinetics of N Release. In this work, the urea release mechanism of SRFs in water was determined by applying four kinetic models (zero-order, first-order, Higuchi, and Korsmeyer−Peppas 51,52 ) to the nitrogen release data and plotting the curves (Figures 9 and S5) and then based on the R 2 regression correlation coefficient values. Tables 2 and S3 list all of the kinetic parameters for the release behavior of the three SRFs and hydrogel fertilizers with different urea loadings under four kinetic models.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Green Slow-Release Coated Nitrogen Fertilizer with High Water Retention Based on Core–Shell-Structured Self-Healing Supramolecular Networks

Zhang,

Yuan

et al. 2024

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

Rubber can improve the mechanical properties of the coated nitrogen fertilizers (CNFs), but the biomass components cause holes in the urea release process, thus accelerating the release of urea. In this study, a self-healing rubber (SHR) shell/hydrogel core based on a supramolecular network was fabricated as a coating material for CNFs to improve the above problems. The core of CNFs consists of vanillin(Van)-cross-linked poly(vinyl alcohol) (PVA)/carboxymethyl chitosan (CMCS) hydrogel, prepared by a freeze−thaw cycle. The shell of CNFs was prepared by soaking Van-cross-linked natural rubber (NR)/chitosan (CS)/PVA material in Zn 2+ solution. A green core− shell structured CNF with hydrogen bonding and metal coordination was finally prepared, which has improved the mechanical properties, slow-release effect, and soil water retention capacity of the CNF. The effects of CS and PVA contents and the impregnation of Zn 2+ on the physical and chemical properties of the SHR supramolecular composite and its self-healing ability were investigated, and the urea release kinetics were analyzed. The CNFs could reach release equilibrium in water for 10 days, with a slow-release rate of 62.7%, and the urea release kinetics were in accordance with the Korsmeyer−Peppas model (R 2 ≥ 0.90), with a possible release mechanism of Fickian diffusion.

show abstract

“…In the bio-related fields, the possibilities of using MCM-41 as a drug delivery system are intensely studied. Shariatinia et al recently reported the use of tert-butylaminefunctionalized MCM-41 as a carrier of cyclophosphamide anticancer drug (Shariatinia et al 2021). The drug was loaded inside the mesopores as well as on the surface of the particles.…”

Section: Mesoporous Silicamentioning

confidence: 99%

Advanced Ordered Nanoporous Materials

Kadja

Nurdini

Krisnandi

et al. 2021

Advanced Functional Porous Materials

View full text Add to dashboard Cite

Ordered nanoporous materials have attracted much attention due to their unique pore architecture, tunable physicochemical properties, which find applications in a broad spectrum of catalysis, separation, adsorption, drug delivery, energy storage, and sensing. In the past decades, the amount of research on ordered nanoporous materials has grown incrementally, resulting in diverse types of these materials with unprecedented structures. Herein, this chapter presents the recent advances of ordered nanoporous materials, including zeolites, ordered mesoporous materials (OMMs), metal-organic frameworks (MOFs), and covalent organic frameworks (COFs). Several vital aspects, i.e., structural and physicochemical properties,

show abstract

tert-Butylamine functionalized MCM-41 mesoporous nanoparticles as drug carriers for the controlled release of cyclophosphamide anticancer drug

Cited by 17 publications

References 47 publications

Effective Distribution of Gold Nanorods in Ordered Thick Mesoporous Silica: A Choice of Noninvasive Theranostics

Effective Distribution of Gold Nanorods in Ordered Thick Mesoporous Silica: A Choice of Noninvasive Theranostics

Green Slow-Release Coated Nitrogen Fertilizer with High Water Retention Based on Core–Shell-Structured Self-Healing Supramolecular Networks

Advanced Ordered Nanoporous Materials

Contact Info

Product

Resources

About