tert-Butyl compounds of gallium

Abstract

The tert-butyl substituted compounds of gallium have been synthesized and characterized: (10), and [Li(HO i Pr) 4 ][( t Bu) 2 GaCl 2 ] (11). X-Ray crystallographic characterization was obtained for compounds 1-6 and 8-11. Compounds 10 and 11 exhibit three-dimensional hydrogen bonded networks in which augmentation of the O-H ؒ ؒ ؒ Cl hydrogen bond is proposed to be due to the increased acidity of alcohols bonded to the Lewis acidic lithium ions. A discussion of the dependence of the puckering of the chair-like conformation in eight-membered cyclic compounds of the Group 13 metals is presented.

Anticancer activity of dinuclear gallium(III) carboxylate complexes

“…Interestingly, the carboxylato ligand is, in terms of bond lengths, almost symmetrically bidentate to two different gallium units. For example, bond lengths Ga (1) [43][44][45][46]51]. Both gallium atoms, the four oxygen atoms and two carbon atoms of the two carboxylate fragments, form a puckered eight-membered ring.…”

“…The puckering of the M 2 O 4 C 2 ring may be considered to be as a result of folding of the eight-membered ring along the two inter-ligand O/O vectors. The extent of folding (q ring ) is defined as the angle between the GaO 2 planes and the O 4 C 2 plane [43,54], that in this case is 50.2 .…”

“…These chelating ligands, stabilize gallium against hydrolysis, and therefore increase the anticancer activity. In spite of their chelating nature and stability, carboxylate gallium(III) complexes have not been studied in the context of medicinal chemistry and only structural properties regarding these compounds have been reported [41][42][43][44][45][46].…”

Novel gallium(III) complexes containing phthaloyl derivatives of neutral aminoacids with apoptotic activity in cancer cells

“…Therefore, many studies on the application of gallium complexes bearing N-, O-or S-donor ligands in anticancer tests have been carried out [28][29][30][31][32][33][34][35][36][37][38], in order to find suitable ligands that stabilize gallium against hydrolysis increasing the cytotoxicity in cancer cells. From all these complexes, carboxylate gallium(III) compounds are missing, and only structural properties regarding these compounds have been reported [39][40][41][42][43][44].…”

Salen-type zirconium complexes with a labile coordination site and a robust skeleton: crystal structure of [(t-Bu4-salen)ZrCl2(H2O)]

“…4). The special interest of complex [1(H 2 O)] is its self-assembling herringbone array stacked by intermolecular hydrogen bonds (O(3) Á Á Á Cl(1) 3.235(5) A; symmetry code: Àx þ 1; y þ 1=2; Àz þ 3=2), the distance of which falls well in the range of the corresponding values (3.03-3.35 A of previously reported supramolecular structures possessing O-H Á Á Á Cl interactions[22][23][24][25][26]. The hydrogen bonding interactions of interlayers are shown in the…”