Terrein Reduces Pulpal Inflammation in Human Dental Pulp Cells

Lee, Jung-Chang; Yu, Mi-Kyung; Lee, Rin; Lee, Younghee; Jeon, Jongho; Jhee, Eun-Chung; Yoo, Ick Dong; Yi, Ho-Keun

doi:10.1016/j.joen.2008.01.015

Cited by 63 publications

(69 citation statements)

References 30 publications

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“…Terrein is a fungal metabolite which has already been shown to have valuable bioactivity in the fields of medicine, cosmetology and agriculture without any cytotoxic effects (22)(23)(24)(25)(26)(27)(28)(29)(30). In the present study, we separated terrein from the fermentation broth of sponge-derived fungus with high efficiency and purity, showing it to be an economic and environmentally-friendly drug candidate (31).…”

Section: Discussionmentioning

confidence: 72%

“…Terrein (4,5-dihydroxy-3-[(E)-1'-propenyl]-2-cyclopenten-l-one, C 8 H 10 O 3 ) was first isolated from Aspergillus terreus Thom in 1935 (22), and has since been tested in several applications across different fields, including the fields of medicine, cosmetology and agriculture (23)(24)(25)(26)(27)(28)(29). However, the biological function of terrein in targeting human diseases has not been extensively investigated.…”

Section: Introductionmentioning

confidence: 99%

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The marine-derived fungal metabolite, terrein, inhibits cell proliferation and induces cell cycle arrest in human ovarian cancer cells

Chen

Wang

Shen

et al. 2014

International Journal of Molecular Medicine

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Abstract. The difficulties faced in the effective treatment of ovarian cancer are multifactorial, but are mainly associated with relapse and drug resistance. Cancer stem-like cells have been reported to be an important contributor to these hindering factors. In this study, we aimed to investigate the anticancer activities of a bioactive fungal metabolite, namely terrein, against the human epithelial ovarian cancer cell line, SKOV3, primary human ovarian cancer cells and ovarian cancer stem-like cells. Terrein was separated and purified from the fermentation metabolites of the marine sponge-derived fungus, Aspergillus terreus strain PF26. Its anticancer activities against ovarian cancer cells were investigated by cell proliferation assay, cell migration assay, cell apoptosis and cell cycle assays. The ovarian cancer stem-like cells were enriched and cultured in a serum-free in vitro suspension system. Terrein inhibited the proliferation of the ovarian cancer cells by inducing G 2 /M phase cell cycle arrest. The underlying mechanisms involved the suppression of the expression of LIN28, an important marker gene of stemness in ovarian cancer stem cells. Of note, our study also demonstrated the ability of terrein to inhibit the proliferation of ovarian cancer stem-like cells, in which the expression of LIN28 was also downregulated. Our findings reveal that terrein (produced by fermention) may prove to be a promising drug candidate for the treatment of ovarian cancer by inhibiting the proliferation of cancer stem-like cells.

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Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

The marine-derived fungal metabolite, terrein, inhibits cell proliferation and induces cell cycle arrest in human ovarian cancer cells

Chen

Wang

Shen

et al. 2014

International Journal of Molecular Medicine

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show abstract

“…Bacterial LPS can also irritate human dental pulp through the dentinal tubules in some cases of mild caries, and pathological pulp changes subsequently occur (18). Previous studies have demonstrated that LPS affects the odontoblastic properties of odontoblast lineage cell lines (19), vascular endothelial growth factor expression in odontoblasts (20), and gene (21) and adhesion molecule expression (22) in human dental pulp cells. However, there are no reports about the direct effect of LPS on human dental pulp cell apoptosis.…”

Section: Introductionmentioning

confidence: 98%

Lipopolysaccharide-induced dental pulp cell apoptosis and the expression of Bax and Bcl-2 in vitro

Yang

Zhu

Cheng

et al. 2010

Braz J Med Biol Res

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“…Human dental pulp cells (HDPC) were isolated and cultured as previously reported (6). In brief, freshly extracted third molar was split, and the dental pulp tissue was separated from the tooth of different person followed by digestion with 3 mg/mL collagenase type II (Sigma, St Louis, MO) and 0.5 mg/mL trypsin (Sigma) for 10 minutes at 37 C. The tissue pieces were seeded into 25-mm 2 cell culture bottle (Corning Corp, Corning, NY) and cultured in Dulbecco modified Eagle medium (DMEM; Gibco, Life Technologies, Grand Island, NY).…”

Section: Pulp Cell Culture and Reagentsmentioning

confidence: 99%

“…Therefore, ICAM-1 and VCAM-1 play an important role in inflammatory reactions. Recently, much research has been focusing on down-regulation of cell adhesion molecules for the palliation of inflammatory reaction (6).…”

mentioning

confidence: 99%

Anti-inflammatory Effect of Peroxisome Proliferator Activated Receptor Gamma on Human Dental Pulp Cells

Lee

Kim

et al. 2009

Journal of Endodontics

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Terrein Reduces Pulpal Inflammation in Human Dental Pulp Cells

Cited by 63 publications

References 30 publications

The marine-derived fungal metabolite, terrein, inhibits cell proliferation and induces cell cycle arrest in human ovarian cancer cells

The marine-derived fungal metabolite, terrein, inhibits cell proliferation and induces cell cycle arrest in human ovarian cancer cells

Lipopolysaccharide-induced dental pulp cell apoptosis and the expression of Bax and Bcl-2 in vitro

Anti-inflammatory Effect of Peroxisome Proliferator Activated Receptor Gamma on Human Dental Pulp Cells

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