Terpyridine-4-amino-1,8-naphthalimide chemosensor for discriminative fluorescent sensing of divalent metal cations at ppb level of sensitivity

Design of 1,8‐Naphthalimide‐Based Fluorescent Functional Molecules for Biological Application: A Review

“…The existing fluorescence materials for ascorbic acid recognition are mostly based on quantum dots. In 2015, Yang et al [61] reported a fluorescence probe (28) for specific recognition of ascorbic acid based on 1,8-naphthalimide (Figure 11b). A nitroxide structure, which can react with ascorbic acid to generate hydroxylamine, was introduced as the recognition group onto the C-4 position of 1,8-naphthalimide.…”

“…In 2023, Shanmugaraju et al synthesized a N-terpyridine-4amino-1,8-naphthalimide fluorescence sensor (7) for discriminatively sensing Cu(II), Co(II), and Ni(II) (Figure 4c). [28] The strong fluorescence emission caused by the ICT process from 4-NH 2 to the imide site was quenched once the rigid terpyridine receptor site at the N-position of 1,8-naphthalimide coordinating with the divalent metal ions to form stable octahedral complexes at a ratio of 2 : 1. Their further work is to develop a water-soluble sensing system for biological application.…”

Tracking the cellular uptake and phototoxicity of Ru(ii)-polypyridyl-1,8-naphthalimide Tröger's base conjugates

“…[3][4][5][6][7][8][9][10][11][12][13] Likewise, Shanmugaraju and co-workers have recently developed several excellent examples of naphthalimide Tro ¨ger's bases and demonstrated their application in a range of supramolecular chemistry applications. [14][15][16][17][18] Ru(II) polypyridyl complexes are known DNA and RNA targeting agents, but a School of Biochemistry and Immunology, Biomedical Sciences Institute, Trinity biological profiling of such complexes has only recently been appreciated and studied in some detail. [19][20][21][22][23][24][25][26][27][28] Hence, the pursuit of Ru(II) polypyridyl complexes as cellular imaging agents and potential theranostics is gathering pace with the recent progression of the thiophane containing TLD1433 to a phase II study for treating non-muscle invasive bladder cancer -the first ruthenium polypridyl based PDT agent to progress to clinical trials.…”

A 1,8-naphthalimide based chemosensor for intracellular and biofluid detection of Pd2+ ions: microscopic and anticounterfeiting studies

“…1,2 As a close analogue of perylene diimide, 1,8-naphthalimide offers many excellent properties due to its ease of functionalization at different positions such as - bay (C-3, C-6), - peri (C-4, C-5), both - bay and - peri (C-3, C-4, C-5, C-6) and N -imide positions. 3 1,8-Naphthalimide has found applications in many areas of chemistry such as molecular recognition (sensing of metal ions, anions, biomolecules and neutral molecules in 50–90% aqueous medium); 4–6 imaging of biomedically relevant species in different organelles such as lysosomes, mitochondria; 7,8 tissue imaging; 9 dyes for colouring synthetic fibres, 10 mechanochromic and solvatochromic dyes; 11,12 fluorescent dyes for solar energy collectors and organic light emitting diodes, 13–15 and nematic liquid crystals for electro optical displays. 16 1,8-Naphthalimide and its metal complexes have been used in antibacterial, antifungal, antiviral, and anticancer applications and as DNA intercalators.…”