Terpenoids isolated from Chinese liverworts Lepidozia reptans and their anti-inflammatory activity

Li, Siwen; Niu, Huanmin; Qiao, Yanan; Zhu, Rongxiu; Sun, Yong; Ren, Zhaojie; Yuan, Huipin; Gao, Yun; Li, Yang; Chen, Wang; Zhou, Jinchuan; Lou, Hongxiang

doi:10.1016/j.bmc.2018.03.040

Cited by 17 publications

(6 citation statements)

References 39 publications

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“…The Modern Chinese Medicine Dictionary reports that C. serratus promotes blood circulation, relieves phlegm and pain, and treats rheumatic joint pain (Song et al 2001). Its antiinflammatory effect is mainly attributed to its terpenoid components (Tang et al 2016;Li et al 2018). Previous experiments have shown that the ethanol extract of C. serratus roots has obvious anti-inflammatory activity (Sun and Li 2013).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects of the root, stem and leaf extracts of Chloranthus serratus on adjuvant-induced arthritis in rats

Sun

Li²,

et al. 2020

Pharmaceutical Biology

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Context: Chloranthus serratus [(Thunb.) Roem. et Schult, (Chloranthaceae)] is a folk medicine used for the treatment of rheumatoid arthritis. Objective: The aim of this study was to investigate anti-arthritic effects of the ethanol extracts of the roots (ER), stems (ES) and leaves (EL) of C. serratus on adjuvant arthritis rats and related mechanisms. Materials and methods: The rats were immunized by intradermal injection of complete Freund's adjuvant (CFA, 0.18 mL) into the right hind feet, and received intragastric administrations of the ER, ES and EL (2.07, 1.61 and 0.58 g/kg/d, respectively) for 14 days. The anti-arthritic activity was assessed by swelling rates, serum indicators, antioxidant capacity, histopathological and immunohistochemical analyses. Results: The LD 50 of the ER, ES and EL was higher than 10.35, 8.05 and 2.90 g/kg/p.o., respectively. Extract treatments decreased swelling rates, tumour necrosis factor-alpha (TNF-a), vascular endothelial growth factor (VEGF), interleukin 1 beta (IL-1b), migration inhibitory factor 1 (MIF-1), immunoglobulin G (IgG) and immunoglobulin M (IgM) levels and positive expression of VEGF in the arthritic rats (p < 0.01 or p < 0.05). The ER significantly decreased NO (3.91 ± 0.61 mmol/L), IL-6 (75.67 ± 16.83 pg/mL) and malondialdehyde (MDA) (2.28 ± 0.32 nmol/mL) contents and clearly increased IFN-c (2082 ± 220.93 pg/mL) and superoxide dismutase (SOD) (601.98 ± 38.40 U/mL) levels. The ES and EL did not reverse the changes in some indicators. All the extracts alleviated inflammatory cell infiltration and synovial cell proliferation. Among them, the ER was the most pronounced. Discussion and conclusions: ER exerts the most promising effects, as shown by inhibiting the releases of inflammatory cytokines and enhancing antioxidant capacity, which provides a scientific basis for further research on C. serratus and its clinical applications.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects of the root, stem and leaf extracts of Chloranthus serratus on adjuvant-induced arthritis in rats

Sun

Li²,

et al. 2020

Pharmaceutical Biology

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“…However, these results were comparable with those previously obtained by other researchers on RAW 264.7 cells. In LPS-induced RAW 264.7 cells, compounds isolated from liverworts such as Mastigophora diclados [ 26 ], Porella densifolia [ 27 ], Lepidozia reptans [ 28 ], and Jamesoniella autumnalis [ 29 ] showed a potent inhibitory effect on the production of NO.…”

Section: Resultsmentioning

confidence: 99%

“…The present study also proved that the methanol extract of liverwort remarkably suppressed the expression of iNOS and COX-2 in LPS-stimulated HaCaT cells. Similarly, dollabellane- and ent-kaurane-type diterpenoids isolated from Chinese liverwort, Lepidozia reptans, effectively attenuated the mRNA expression of IL-6, IL-β, IL-α, TNF-α, and COX-2 in LPS-stimulated RAW264.7 cells [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Effect of Liverwort (Marchantia polymorpha L.) and Racomitrium Moss (Racomitrium canescens (Hedw.) Brid.) Growing in Korea

Kim

Hong

Kim

et al. 2021

Plants

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Bryophytes contain a variety of bioactive metabolites, but studies about the anti-inflammatory effect of bryophytes are meager. Therefore, the present study aimed to compare the anti-inflammatory effect of methanol extract of Marchantia polymorpha L. (liverwort) and Racomitrium canescens (Racomitrium moss) in lipopolysaccharide (LPS)-induced HaCaT cells. To evaluate the anti-inflammatory effect of liverwort and Racomitrium moss, the levels of nitric oxide (NO) production and the mRNA expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and tumor necrosis factor-α (TNF-α), and interleukin (IL)-6 and IL-1β in LPS-induced HaCaT cells were measured. The methanol extract of liverwort and Racomitrium moss significantly decreased LPS-induced NO production in HaCaT cells. When compared with Racomitrium moss extract, pre-treatment with methanol extract of liverwort markedly inhibited the expression of iNOS, COX-2, IL-6, and IL-1β at the concentration of 100 µg/mL with the exception of TNF-α. Further, liverwort extract markedly attenuated the production of TNF-α, IL-6, and IL-1β in the culture medium. In addition, ethyl acetate and butanol fractions obtained from the methanol extract of liverwort showed remarkable inhibitory activity against the production of NO in LPS-stimulated HaCaT cells. The LC-MS data revealed the presence of bisbibenzyl types of bioactive components in the methanol extract of liverwort. These data demonstrate that liverwort extract exhibits effective inhibitory activity against the production of inflammatory mediators in LPS-induced HaCaT cells and may be useful for the treatment of inflammation-mediated diseases.

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“…One known ent -eudesmane-type sesquiterpenoid, namely, (6 R ,7 S ,10 R )-6,7-dihydroxy-3-oxo-eudesma-4 E -ene (7), was isolated and identified by comparing their observed and reported ESIMS and NMR data. 21 …”

Section: Resultsmentioning

confidence: 99%

Cyperane and eudesmane-type sesquiterpenoids from Chinese liverwort and their anti-diabetic nephropathy potential

et al. 2018

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Terpenoids isolated from Chinese liverworts Lepidozia reptans and their anti-inflammatory activity

Cited by 17 publications

References 39 publications

Anti-inflammatory effects of the root, stem and leaf extracts of Chloranthus serratus on adjuvant-induced arthritis in rats

Anti-inflammatory effects of the root, stem and leaf extracts of Chloranthus serratus on adjuvant-induced arthritis in rats

Anti-Inflammatory Effect of Liverwort (Marchantia polymorpha L.) and Racomitrium Moss (Racomitrium canescens (Hedw.) Brid.) Growing in Korea

Cyperane and eudesmane-type sesquiterpenoids from Chinese liverwort and their anti-diabetic nephropathy potential

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