Terpenoids from the medicinal mushroom<i>Antrodia camphorata</i>: chemistry and medicinal potential

Kuang, Yi; Li, Bin; Wang, Zilong; Qiao, Xue

doi:10.1039/d0np00023j

Cited by 72 publications

(77 citation statements)

References 138 publications

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“…Recent studies have found that A. camphorata is rich in a variety of active compounds such as polysaccharides, triterpenoids, adenosine, polypeptides, vitamins, trace elements, nucleic acids, and sterols [11]. The ergostane-type triterpenoids was characteristic constituents of A. camphorata [19]. The ergostane-type triterpenoids (Antcin B, Antcin K and Antcin H) could protect against liver injury in vivo or vitro.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Spore Powder of Antrodia camphorata ATCC 200183 on CCl4-Induced Liver Fibrosis in Mice

Ren

Zhou

et al. 2020

Nutrients

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Liver fibrosis is a pathological process with intrahepatic diffused deposition of the excess extracellular matrix, which leads to various chronic liver diseases. Drugs with high efficacy and low toxicity for liver fibrosis are still unavailable. Antrodia camphorata has antioxidant, antivirus, antitumor and anti-inflammation roles, and has been used to treat liver diseases in the population. However, the hepatoprotective effects of A. camphorata spores and the mechanisms behind it have not been investigated. In this study, we evaluate the hepatoprotective effect of spore powder of A. camphorata (SP, 100 mg/kg/day or 200 mg/kg/day) on carbon tetrachloride (CCl4)-induced liver fibrosis in mice. SP groups reduced serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities compared with the CCl4 group. SP also showed a decrease in hydroxyproline (Hyp) content in liver tissues. SP improved cell damage and reduced collagen deposition by H&E, Sirius red and Masson staining. Furthermore, SP down-regulated the mRNA levels of α-SMA and Col 1, and the protein expression of α-smooth muscle actin (α-SMA), collagen I (Col 1), tumor necrosis factor alpha (TNF-α), toll like receptor 4 (TLR4) and nuclear factor-Κb (NF-κB) p65. In summary, SP has an ameliorative effect on hepatic fibrosis, probably by inhibiting the activation of hepatic stellate cells, reducing the synthesis of extracellular matrix.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Spore Powder of Antrodia camphorata ATCC 200183 on CCl4-Induced Liver Fibrosis in Mice

Ren

Zhou

et al. 2020

Nutrients

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Section: Introductionmentioning

confidence: 99%

“…Taiwanofungus camphoratus (Antrodia cinnamomea), often referred to as 'Niu-chang-chih', is a medicinal fungus that only grows on the native tree Cinnamomum kanehirai Hayata in Taiwan (7). Several bioactive compounds are present in Taiwanofungus camphoratus, including polysaccharides, triterpenes, diterpenes, succinic acid derivatives, and ubiquinone (7). 4-Acetylantroquinonol B (4-AAQB) is the ubiquinone derivative of Taiwanofungus camphoratus, which is identified as the major antiproliferative compound for hepatoma cells (8).…”

Section: Introductionmentioning

confidence: 99%

4‑Acetylantroquinonol B enhances cell death and inhibits autophagy by downregulating the PI3K/Akt/MDR1 pathway in gemcitabine‑resistant pancreatic cancer cells

Chen

et al. 2022

Oncol Lett

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Gemcitabine (GEM) is a typical chemotherapeutic drug used to treat pancreatic cancer, but GEM resistance develops within weeks after chemotherapy. Hence, the development of a new strategy to overcome drug resistance is urgent. 4-Acetylantroquinonol B (4-AAQB), a ubiquinone derived from Taiwanofungus camphoratus, has hepatoprotective, anti-obesity, and antitumor activities. However, the role of 4-AAQB in enhancing GEM sensitivity is unclear. This study aimed to determine the underlying mechanisms by which 4-AAQB enhances cytotoxicity and GEM sensitivity. Cell viability was dramatically reduced by 4-AAQB (2 and 5 µM) treatment in the MiaPaCa-2 and GEM-resistant MiaPaCa-2 (MiaPaCa-2 GEMR ) human pancreatic cancer cells. 4-AAQB led to cell cycle arrest, upregulated the levels of reactive oxygen species (ROS), promoted apoptosis, and inhibited autophagy, which subsequently enhanced GEM chemosensitivity by suppressing the receptor for advanced glycation end products (RAGE)/high mobility group box 1 (HMGB1)-initiated PI3K/Akt/multidrug resistance protein 1 (MDR1) signaling pathway in both cell lines. Vascular endothelial growth factor A (VEGFA) expression, cell migration, and invasion were also inhibited by the 4-AAQB incubation. Overall, this combination treatment strategy might represent a novel approach for GEM-resistant pancreatic cancer.

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“…Consequently, a wealth of novel skeletons, biosynthetic pathways, and bioactivities have provided new opportunities for drug discovery, genome mining, enzymology, and chemical synthesis. During the period covered in this review, there have been several more specialized reviews of fungal metabolites [ 26 , 27 , 28 ], including benzene carbaldehydes [ 29 ], trichothecenes [ 30 , 31 ], protoilludane sesquiterpenoids [ 32 ], meroterpenoids [ 33 , 34 , 35 ], meroterpenoid cyclases [ 36 ], terpenoids [ 37 ], and natural product biosynthetic genes and enzymes of fungi [ 17 , 18 , 38 , 39 ]. In addition, the isolation and chemistry of diterpenoids from terrestrial sources have been summarized [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Diterpenes Specially Produced by Fungi: Structures, Biological Activities, and Biosynthesis (2010–2020)

Zhang

Feng

2022

JoF

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Fungi have traditionally been a very rewarding source of biologically active natural products, while diterpenoids from fungi, such as the cyathane-type diterpenoids from Cyathus and Hericium sp., the fusicoccane-type diterpenoids from Fusicoccum and Alternaria sp., the guanacastane-type diterpenoids from Coprinus and Cercospora sp., and the harziene-type diterpenoids from Trichoderma sp., often represent unique carbon skeletons as well as diverse biological functions. The abundances of novel skeletons, biological activities, and biosynthetic pathways present new opportunities for drug discovery, genome mining, and enzymology. In addition, diterpenoids peculiar to fungi also reveal the possibility of differing biological evolution, although they have similar biosynthetic pathways. In this review, we provide an overview about the structures, biological activities, evolution, organic synthesis, and biosynthesis of diterpenoids that have been specially produced by fungi from 2010 to 2020. We hope this review provides timely illumination and beneficial guidance for future research works of scholars who are interested in this area.

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Terpenoids from the medicinal mushroomAntrodia camphorata: chemistry and medicinal potential

Abstract: This review article summarizes the research progress on terpenoids from the medicinal mushroom Antrodia camphorata during 1995–2020, including structural diversity, resources, biosynthesis, pharmacological activities, metabolism, and toxicity.

Cited by 72 publications

References 138 publications

Protective Effect of Spore Powder of Antrodia camphorata ATCC 200183 on CCl4-Induced Liver Fibrosis in Mice

Protective Effect of Spore Powder of Antrodia camphorata ATCC 200183 on CCl4-Induced Liver Fibrosis in Mice

4‑Acetylantroquinonol B enhances cell death and inhibits autophagy by downregulating the PI3K/Akt/MDR1 pathway in gemcitabine‑resistant pancreatic cancer cells

Diterpenes Specially Produced by Fungi: Structures, Biological Activities, and Biosynthesis (2010–2020)

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