Terpenoids from<i>Teucrium montanus</i>subsp.<i>pannonicum</i>

Kisiel, Wanda; Piozzi, Franco; Grzybek, J

doi:10.1055/s-2006-958050

Cited by 7 publications

(2 citation statements)

References 2 publications

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“…Flowered aerial parts and its polar extracts are commonly used in European medicine for their neurosedative activities [1,2,3]. Previously chemical investigation of the plant resulted in isolation of flavonoids − apigenin7-glucoside [4], vicenin-2 [4] and tangeretin [5] − and labdane diterpenoids − ballotinone [6], ballonigrine [7], 7α-acetoxymarrubiin [8], ballotenol [9], preleosibirin [10], and 13-hydroxyballonigrinolide [11]. More recently studies of an hydroalcoholic extract of Ballota nigra led to the isolation of eight phenylpropanoid compounds derived from the esterification of hydroxycinnamic acid [12,13,14] including a non-glycosidic derivative (+)-(E)-caffeoyl-Lmalic acid 1, and seven phenylpropanoid glycosides, verbascoside 2, forsythoside B 3, arenarioside 4, ballotetroside 5, alyssonoside 6, lavandulifolioside 7, and angoroside A 8 (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

Neurosedative and Antioxidant Activities of Phenylpropanoids from Ballota nigra

Daels-Rakotoarison

Seidel²,

Gressier

et al. 2011

Arzneimittelforschung

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Ballota nigra is a European plant known for its neurosedative properties. In this study, the ability of five phenylpropanoids (verbascoside, forsythoside B, arenarioside, ballotetroside, and caffeoyl malic acid) isolated from a hydroalcoholic extract, to bind to benzodiazepine, dopaminergic, and morphinic receptors was investigated. To carry out these studies, affinity tests with rat striata, entire brains and receptor rich preparations were employed. In addition, the phenolic aspect of these five phenylpropanoid esters led to investigate antioxidant activities using cell-free experiments and cellular experiments including isolated polymorphonuclear neutrophils (PMN). Effects of phenylpropanoid esters against reactive oxygen species as superoxide anion, peroxide hydrogen, hypochlorous acid and hydroxyl radical were tested. These molecules are liberated by PMN during inflammatory disorders, so that reproduction of this process in vitro stimulating PMN by chemical stimulants was undertaken. Results show that four of the five compounds are able to bind to the studied receptors. Inhibitory concentrations at 50% were determined and vary from 0.4 to 4.7 mg/ml. This may be in relation with the Ballota nigra known neurosedative activities. Results concerning antioxidant investigations evidence an ability to scavenge reactive oxygen species. Inhibitory concentrations at 50% obtained are comparable to those of known antioxidant drugs (mesna or N-acetyl cysteine). Moreover, the use of different stimuli having various pathways of action on PMN oxidative metabolism permits to establish that each phenylpropanoid ester has its own particular way of action by using proteine kinase C or phospholipase C pathways.

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Section: Introductionmentioning

confidence: 99%

Neurosedative and Antioxidant Activities of Phenylpropanoids from Ballota nigra

Daels-Rakotoarison

Seidel²,

Gressier

et al. 2011

Arzneimittelforschung

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“…1,2 Phytochemical studies reveal that this genus contains a large variety of compounds, mainly diterpenoids, 3,4 steroids, 5 iridoids and flavonoids, 6 and as aromatic plant, essential oils. Pharmacological assays show that neo-clerodane diterpenoids are responsible for the antifeedant and hepatotoxic activities, 7,8 while antibacterial, analgesic and antispasmodic activities can be attributed to the volatile oils.…”

Section: Introductionmentioning

confidence: 99%

Essential oil analysis of Teucrium libanitis and T. turredanum by GC and GC–MS

Blázquez

Pérez

Boira

2003

Flavour & Fragrance J

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The chemical composition of the six essential oils obtained from Teucrium libanitis and Teucrium turredanum collected at different localities was analysed by GC and GC-MS. Fifty-three constituents were identified. The oil of T. libanitis is characterized by the monoterpene α-pinene (9.9-21.2%) and the sesquiterpene δ-cadinene (5.3-9.7%), while that of T. turredanum had a higher content of sesquiterpenoids: β-caryophyllene (15.6-32.6%), α-humulene (4.7-10.1%) and β-bisabolol (6.4-8.3%), and a lower percentage of monoterpenoids (<1%). A multivariate procedure (hierarchical clustering) for detecting natural grouping established that T. libanitis and T. turredanum constitute two independent taxa.

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Chemotaxonomy of Serbian Teucrium Species Inferred from Essential Oil Chemical Composition: the Case of Teucrium scordium L. ssp. scordioides

Radulović

Dekić

Vukićević

2012

Chemistry & Biodiversity

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The volatile constituents of Teucrium scordium L. ssp. scordioides, T. polium, and T. montanum, obtained by hydrodistillation, were investigated by GC-FID and GC/MS analyses. A total of 296 constituents were identified, representing 89.8-98.4% of the oil compositions. The oils of T. polium and T. montanum consisted mainly of sesquiterpenes (64.3 and 72.7%, resp.), with germacrene D (4; 31.0%) and δ-cadinene (10; 8.1%) as the main constituents, respectively. In contrast, the monoterpene menthofuran (1; 11.9%) predominated in the oil of T. scordium ssp. scordioides, and this clearly distinguished this species from the other Teucrium taxa investigated up to date. The chemistry of the volatiles of eight Teucrium taxa from Serbia and Montenegro were compared using multivariate statistical analysis, and this provided chemotaxonomically important conclusions.

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Terpenoids fromTeucrium montanussubsp.pannonicum

Abstract: Clerosterol and clerosteryl acylglucosides were identified as the most abundant steroids of the aerial parts of Teucrium montanum L. subsp. pannonicum (Kern.) S. Pawł. Other constituents isolated were the neo-clerodane diterpenes auropolin and montanin H, and widespread triterpenes.

Cited by 7 publications

References 2 publications

Neurosedative and Antioxidant Activities of Phenylpropanoids from Ballota nigra

Neurosedative and Antioxidant Activities of Phenylpropanoids from Ballota nigra

Essential oil analysis of Teucrium libanitis and T. turredanum by GC and GC–MS

Chemotaxonomy of Serbian Teucrium Species Inferred from Essential Oil Chemical Composition: the Case of Teucrium scordium L. ssp. scordioides

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