Terpenoids as Source of Anti-Inflammatory Compounds

Abstract

Terpenoids accounts for the major class of secondary metabolites produced by plants. It shows defense activity against environmental stress and help to heal injuries. Medicinal plants are rich in monoterpenoids, diterpenoids, sesquiterpenes, triterpenes, tetraterpenes, and ceramide. A number of therapeutic applications such as antibacterial, antimicrobial, antitumor, anti-inflammatory activity have been identified. Terpenoids are compounds similar to terpenes derived from 5-carbon monomer isoprene units. The review puts and detail insight on different class of compounds isolated from natural source from 2000 to 2016 showing anti-inflammatory potential of pharmacologically interesting agent and their mechanism of action.

A Review on Medicinal Properties of Centella Asiatica

“…It helps to cope up stress condition and supports defense activities. Plants with medicinal properties are rich in these compounds such as ceramide and different forms of terpenoids [35]. Pentacyclic triterpenoid and saponins are collectively known as centelloids.…”

Anti-Inflammatory Activity of Bacteria Associated With Marine Sponge (Haliclona Amboinensis) via Reducting No Production and Inhibiting Cyclooxygenase-1, Cyclooxygenase-2, and Secretory Phospholipase A2 Activities

“…Phytochemical properties of the samples had a correlation with their therapeutic properties. Some studies have reported that alkaloid and terpenoids compounds have many potentials as antibacterial [2,3], anticancer and antitumor [4], antidiabetic and antioxidant [5], and anti-inflammatory [6,7] agents. Moreover, alkaloids from marine invertebrates such as sponges are reported to be anti-inflammatory potentials [21].…”

“…This study investigated a new source from nature, namely sponges, as a potential alternative medicine that can reduce inflammation. There are some active compounds from sponges that have proven beneficial to humans such as anti-bacteria, anticancer, antidiabetic and antioxidant, antifouling, and anti-inflammatory [2][3][4][5][6][7].…”

Inhibitory Effects on Tumor Necrosis Factor Alpha and Interleukin 12 Using Clobetasol Propionate Loaded Tea Tree Oil Nanoemulsion Gel on Animal Model

“…Worldwide 2-3 % of population suffering from such kind of skin disease [1]. The exact cause of this disease is still not clear but it is assumed that it may be mainly due to the activation and migration of T cells to the dermis which triggering the release of cytokines tumor necrosis factor alpha (TNF-α) ultimately lead to the inflammatory process and the rapid proliferation of skin cells.…”