Terpenoids’ anti-cancer effects: focus on autophagy

El-Baba, Chirine; Baassiri, Amro; Kiriako, Georges; Dia, Batoul; Fadlallah, Sukayna; Moodad, Sara; Darwiche, Nadine

doi:10.1007/s10495-021-01684-y

Cited by 74 publications

(40 citation statements)

References 298 publications

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“…According to the number of their isoprene units, they are divided into several categories, including hemiterpenoids, monoterpenoids, sesquiterpenoids, etc. [ 92 ]. It has been shown that terpenoids ameliorated experimental colitis by reducing colonic injury and inflammation and possibly by decreasing permeability [ 93 ].…”

Section: Phytochemicals Targeting the Tlr4mentioning

confidence: 99%

Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease

et al. 2022

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Inflammatory bowel disease (IBD) is a collective term for inflammatory diseases including Crohn’s disease and ulcerative colitis. Toll-like receptor 4 (TLR4) is thought to play a key role in the pathogenesis of IBD. Inhibition of TLR4 has been recognized as an effective target for the treatment of IBD. Many phytochemicals have been shown to have potential as new drugs for the treatment of IBD. This review surveyed the available literature and reports which focused on the in vivo effects of phytochemicals targeting TLR4 in different models of IBD, and clarified the significance of TLR4 as a current therapeutic target for IBD. Based on our review, we have concluded that phytochemicals targeting TLR4 are potentially effective candidates for developing new therapeutic drugs against IBD.

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Section: Phytochemicals Targeting the Tlr4mentioning

confidence: 99%

Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease

et al. 2022

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“…With regard to the special influence of supramolecular chemistry on the theory of TCMs, standing on the shoulders of our predecessors, we hypothesized that, TCM was a complex supramolecular systems in nature, in which a certain amount of self-assembled NSMs may bear the responsibility to deliver main active ingredients into the target organs through co-assembly or encapsulation so as to elicit the multi-effects via multiple targets, levels and pathways in the bodies and finally treat the diseases [ [126] , [127] , [128] , [129] , [130] ]. Notably, some NSMs not only served as the carriers for encapsulating and delivering, but also played therapeutic effects such as terpenoids and steroids, which were known to the scientists for their anticancer, anti-inflammatory and antioxidant activities [ [131] , [132] , [133] , [134] , [135] , [136] ]. It is also an important manifestation of TCMs－“the unification of drug and adjuvant” [ 137 ].…”

Section: New Supramolecular System Hypothesis Of Tcmsmentioning

confidence: 99%

Supramolecular assemblies based on natural small molecules: Union would be effective

Hou

Zou

et al. 2022

Materials Today Bio

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“…Terpenoids are the largest class of natural products, most of which are of plant origin, and their biological properties, mainly anti-proliferative and apoptotic, have been shown to play an important role in cancer prevention and health promotion through the promotion of autophagy ( Martel et al, 2019 ; El-Baba et al, 2021 ). Therefore, plant-derived terpenoids components will provide a novel approach for mediating autophagy in the treatment of OA.…”

Section: Phytochemicals For the Treatment Of Oa By Promoting Autophagymentioning

confidence: 99%

Phytochemicals Mediate Autophagy Against Osteoarthritis by Maintaining Cartilage Homeostasis

2021

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Osteoarthritis (OA) is a common degenerative joint disease and is a leading cause of disability and reduced quality of life worldwide. There are currently no clinical treatments that can stop or slow down OA. Drugs have pain-relieving effects, but they do not slow down the course of OA and their long-term use can lead to serious side effects. Therefore, safe and clinically appropriate long-term treatments for OA are urgently needed. Autophagy is an intracellular protective mechanism, and targeting autophagy-related pathways has been found to prevent and treat various diseases. Attenuation of the autophagic pathway has now been found to disrupt cartilage homeostasis and plays an important role in the development of OA. Therefore, modulation of autophagic signaling pathways mediating cartilage homeostasis has been considered as a potential therapeutic option for OA. Phytochemicals are active ingredients from plants that have recently been found to reduce inflammatory factor levels in cartilage as well as attenuate chondrocyte apoptosis by modulating autophagy-related signaling pathways, which are not only widely available but also have the potential to alleviate the symptoms of OA. We reviewed preclinical studies and clinical studies of phytochemicals mediating autophagy to regulate cartilage homeostasis for the treatment of OA. The results suggest that phytochemicals derived from plant extracts can target relevant autophagic pathways as complementary and alternative agents for the treatment of OA if subjected to rigorous clinical trials and pharmacological tests.

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Terpenoids’ anti-cancer effects: focus on autophagy

Cited by 74 publications

References 298 publications

Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease

Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease

Supramolecular assemblies based on natural small molecules: Union would be effective

Phytochemicals Mediate Autophagy Against Osteoarthritis by Maintaining Cartilage Homeostasis

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