Terpenoid-rich Elettaria cardamomum extract prevents Alzheimer-like alterations induced in diabetic rats via inhibition of GSK3β activity, oxidative stress and pro-inflammatory cytokines

Gomaa, Adel A.; Makboul, Rania; El‐Mokhtar, Mohamed A.; Abdel‐Rahman, Engy A.; Ahmed, Israa A.; Nicola, Mariam A.

doi:10.1016/j.cyto.2018.10.017

Cited by 25 publications

(17 citation statements)

References 35 publications

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“…In addition, previous reports have shown a significant decrease in brain SOD levels in patients with AD, and increased SOD enzyme activity may be a therapeutic strategy to inhibit the progression of AD. SOD combats the toxicity of oxygen radicals by catalyzing the reduction of superoxide radical anions into hydrogen peroxide (Gomaa et al., 2019 ). So that we analyzed the activity of PSH-Px ( Figure 7(A) ), SOD ( Figure 7(B) ), and MDA content ( Figure 7(C) ) in brain tissue to evaluate the ability of varying formulations against oxidative stress.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer’s disease

et al. 2022

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The blood–brain barrier (BBB) is a protective barrier for brain safety, but it is also a major obstacle to the delivery of drugs to the cerebral parenchyma such as the hippocampus, hindering the treatment of central nervous system diseases such as Alzheimer’s disease (AD). In this work, an anti-AD brain-targeted nanodrug delivery system by co-loading icariin (ICA) and tanshinone IIA (TSIIA) into Aniopep-2-modified long-circulating (Ang2-ICA/TSIIA) liposomes was developed. Low-density lipoprotein receptor-related protein-1 (LRP1) was a receptor overexpressed on the BBB. Angiopep-2, a specific ligand of LRP1, exhibited a high binding efficiency with LRP1. Additionally, ICA and TSIIA, drugs with neuroprotective effects are loaded into the liposomes, so that the liposomes not only have an effective BBB penetration effect, but also have a potential anti-AD effect. The prepared Ang2-ICA/TSIIA liposomes appeared narrow dispersity and good stability with a diameter of 110 nm, and a round morphology. Cell uptake observations, BBB models in vitro , and imaging analysis in vivo showed that Ang2-ICA/TSIIA liposomes not only penetrate the BBB through endocytosis, but also accumulate in N2a cells or brain tissue. The pharmacodynamic analysis in vivo demonstrated that Ang2-ICA/TSIIA liposomes could improve AD-like pathological features in APP/PS1 mice, including inhibiting neuroinflammation and oxidative stress, reducing apoptosis, protecting neurons, and improving cognitive function. Therefore, Ang2-ICA/TSIIA liposomes are considered a potentially effective therapeutic strategy for AD.

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Section: Resultsmentioning

confidence: 99%

Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer’s disease

et al. 2022

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“…The extensively used spice saffron is rich in volatile compounds wherein safranal is the most abundant non-volatile compound of saffron. Non-volatile compounds like crocins, crocetin, quercetin and kaempferol, isophorones, carotenoids, zeaxanthin, lycopene, etc., are present in saffron ( Gomaa et al, 2019 ; Chowdhury and Kumar, 2020 ). Saffron and its bioactive phytocompounds are speculated to have an effect on AChE activity, dopamine pathways signaling, Aβ peptides and tau aggregate formation, ROS, activation of glial cells, notch pathway, Keap1/Nrf2 signaling pathway, mitogen-activated protein kinases signaling pathway, etc.…”

Section: Tau Hypophosphorylationmentioning

confidence: 99%

“…Saffron has been reported to prevent abnormal indicators such as cognitive performance, cognitive function, motor dysfunction, tremors, spasm and convulsions. Therefore, saffron has been postulated to treat various brain-related disorders; including Alzheimer’s ( Gomaa et al, 2019 ; Chowdhury and Kumar, 2020 ).…”

Section: Tau Hypophosphorylationmentioning

confidence: 99%

Natural Therapeutics in Aid of Treating Alzheimer’s Disease: A Green Gateway Toward Ending Quest for Treating Neurological Disorders

et al. 2022

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The current scientific community is facing a daunting challenge to unravel reliable natural compounds with realistic potential to treat neurological disorders such as Alzheimer’s disease (AD). The reported compounds/drugs mostly synthetic deemed the reliability and therapeutic potential largely due to their complexity and off-target issues. The natural products from nutraceutical compounds emerge as viable preventive therapeutics to fill the huge gap in treating neurological disorders. Considering that Alzheimer’s disease is a multifactorial disease, natural compounds offer the advantage of a multitarget approach, tagging different molecular sites in the human brain, as compared with the single-target activity of most of the drugs so far used to treat Alzheimer’s disease. A wide range of plant extracts and phytochemicals reported to possess the therapeutic potential to Alzheimer’s disease includes curcumin, resveratrol, epigallocatechin-3-gallate, morin, delphinidins, quercetin, luteolin, oleocanthal, and other phytochemicals such as huperzine A, limonoids, and azaphilones. Reported targets of these natural compounds include inhibition of acetylcholinesterase, amyloid senile plaques, oxidation products, inflammatory pathways, specific brain receptors, etc. We tenaciously aimed to review the in-depth potential of natural products and their therapeutic applications against Alzheimer’s disease, with a special focus on a diversity of medicinal plants and phytocompounds and their mechanism of action against Alzheimer’s disease pathologies. We strongly believe that the medicinal plants and phytoconstituents alone or in combination with other compounds would be effective treatments against Alzheimer’s disease with lesser side effects as compared to currently available treatments.

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“…Particularly, indole, isoquinoline, isosteroid, and nicotine alkaloids act by scavenging free radicals and by reducing iron and molybdate [254][255][256][257]. Terpenoids reportedly exert their activity by inhibiting lipid oxidation and International Journal of Agronomy reducing oxidative stress [258]. Although not as much as other phytochemicals, saponins from different plant extracts have also been found to inhibit the formation of reactive oxygenated species [259][260][261].…”

Section: Antioxidants Preservativesmentioning

confidence: 99%

Promising Natural Products in Crop Protection and Food Preservation: Basis, Advances, and Future Prospects

Ogunnupebi

Oluyori

Dada

et al. 2020

International Journal of Agronomy

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The increase in demand for agricultural produce necessitates the continuous search for affordable, ecofriendly, readily available crop protectors, and food preservatives. Historically, the use of various chemicals was employed in controlling plant diseases and to maintain food quality. In the past few decades, several natural product-based alternatives have been discovered and projected as better alternatives to synthetic pesticides and other synthetic agrochemicals. Recent studies focusing on the application of different botanicals in crop protection and food preservation were carefully selected and reviewed. The application of plant extract in the biogenic preparation of nanoparticles was also reviewed. This review confirms that several natural products can be used as a safe replacement for synthetic agrochemicals. Different plant extracts have also served as feed for the synthesis of nanoparticle, which is increasingly applicable in crop protection and food preservation.

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Terpenoid-rich Elettaria cardamomum extract prevents Alzheimer-like alterations induced in diabetic rats via inhibition of GSK3β activity, oxidative stress and pro-inflammatory cytokines

Cited by 25 publications

References 35 publications

Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer’s disease

Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer’s disease

Natural Therapeutics in Aid of Treating Alzheimer’s Disease: A Green Gateway Toward Ending Quest for Treating Neurological Disorders

Promising Natural Products in Crop Protection and Food Preservation: Basis, Advances, and Future Prospects

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