Terpenes of the Genus Salvia: Cytotoxicity and Antitumoral Effects

Campos-Xolalpa, Nimsi; Pérez-Gutiérrez, Salúd; Pérez-González, Cuaúhtemoc; Mendoza-Pérez, Julia; Alonso-Castro, Ángel Josabad

doi:10.1007/978-981-10-8064-7_8

Cited by 3 publications

(2 citation statements)

References 110 publications

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“…Furthermore, the pharmaceutical activity of these oxygenated monoterpenes was also associated with aromatic compounds having other stimulant activities such as astringent, diuretic, and carminative (Al-Zereini et al, 2022). Terpenoid compounds are commonly found in plants, animals, and fungi consisting of two or more isoprene units (Campos-Xolalpa et al, 2018). This terpenoid compound consists of an ionone or chalcone framework, which has various pharmacological properties, one of which is a cytotoxic agent and anticancer (Lima et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Optimization of Cardamom Fruit (Amomum compactum) Extraction Focused on Total Terpenoid Extraction and Cytotoxic Activity Using Response Surface Methodology

Juliana,

Priosoeryanto,

Nurcholis

2023

J Jamu Indo

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Cardamom is one of the medicinal plants called perennial herbs from the Zingiberaceae family. Cardamom, with the scientific name Amomum compactum, contains various phytochemical compounds such as terpenoids, flavonoids, phenolics, tannins, sterols, and proteins that are pharmacologically useful as an anticancer, antioxidant, and have cytotoxic activity. Testing the total content of terpenoid compounds that affect the cytotoxic activity of A. compactum fruit using Box-Behnken Design with three independent variables (solvent ratio, ethanol concentration, and extraction time) has never been studied before. Thus, this study aimed to obtain the extraction optimization conditions on the total terpenoid content and cytotoxic activity using Artemia salina Leach larvae with the response surface method, namely Box-Behnken Design with Design Expert 13.0 application. Determination of the total terpenoid content of the A. compactum fruit extract was carried out based on the standard ursalic acid, and the cytotoxic activity was carried out using the Brine Shrimp Lethality Test (BSLT) method. The maximum total terpenoid obtained was 4.8970 mg UAE/g DW, and the minimum IC50 value was 38.8813 ppm. Optimal conditions for the extraction of A. compactum fruit obtained a combination of 1:8 mL/g solvent ratio, 50% ethanol concentration, and extraction time of 1 day with a desirability value of 0.772. Furthermore, the optimal extraction solution results from the Box-Behnken Design were verified and analyzed using a One-Sample T-Test. Using the Box-Behnken Design extraction optimization method, the content of terpenoid bioactive compounds with cytotoxic activity from A. compactum fruit can be optimally obtained.

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Section: Introductionmentioning

confidence: 99%

Optimization of Cardamom Fruit (Amomum compactum) Extraction Focused on Total Terpenoid Extraction and Cytotoxic Activity Using Response Surface Methodology

Juliana,

Priosoeryanto,

Nurcholis

2023

J Jamu Indo

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“…Many efforts have been made to discover the potential therapeutic effects of diterpenes from Salvia species for cardiovascular disease . However, according to one estimate, among 700 isolated compounds of Salvia genus reported, only 100 terpenoids have been isolated from 24 Salvia species, and less than half of these showed cytotoxic activity against cancer cells, including nine sesquiterpenoids …”

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confidence: 99%

Glechomanamides A–C, Germacrane Sesquiterpenoids with an Unusual Δ⁸-7,12-Lactam Moiety from Salvia scapiformis and Their Antiangiogenic Activity

et al. 2019

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Three new germacrane sesquiterpenoid-type alkaloids with an unusual Δ8-7,12-lactam moiety, glechomanamides A–C (1–3), and two pairs of 7,12-hemiketal sesquiterpenoid epimers (4a/b, 5a/b) were isolated from Salvia scapiformis. Their structures were elucidated by spectroscopic methods including HRESIMS, IR, UV, and 1D and 2D NMR and also confirmed by single-crystal X-ray diffraction analysis. The chemical transformation of compounds 1–5 in a solution environment was analyzed by 2D NMR spectroscopy. The aza acetallactams (1–3) were stable in organic solvent, while single crystals of the hemiacetal esters (4a/b, 5a/b) underwent a tautomeric equilibrium after being dissolved. Single crystals of 4a, 4b, and 5a were obtained for the first time as their naturally occurring forms. Glechomanamide B (2) exhibited antiangiogenic activity by suppression of vascular endothelial growth factor (VEGF)-induced tube formation through modulation of VEGF receptor 2 (VEGFR2)-mediated signaling pathways in human umbilical vascular endothelial cells (HUVECs). In addition, compound 2 also showed the significant suppression of mRNA expression associated with glycolysis and angiogenesis biomarkers in high glucose (30 mM)-induced HUVECs. These findings suggest that compound 2 might be a potential lead compound candidate for the management of diabetic retinopathy.

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The impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar

Bowen

Chaparro

McCorkle

et al. 2021

Sci Rep

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The last two decades have seen a dramatic shift in cannabis legislation around the world. Cannabis products are now widely available and commercial production and use of phytocannabinoid products is rapidly growing. However, this growth is outpacing the research needed to elucidate the therapeutic efficacy of the myriad of chemical compounds found primarily in the flower of the female cannabis plant. This lack of research and corresponding regulation has resulted in processing methods, products, and terminology that are variable and confusing for consumers. Importantly, the impact of processing methods on the resulting chemical profile of full spectrum cannabis extracts is not well understood. As a first step in addressing this knowledge gap we have utilized a combination of analytical approaches to characterize the broad chemical composition of a single cannabis cultivar that was processed using previously optimized and commonly used commercial extraction protocols including alcoholic solvents and super critical carbon dioxide. Significant variation in the bioactive chemical profile was observed in the extracts resulting from the different protocols demonstrating the need for further research regarding the influence of processing on therapeutic efficacy as well as the importance of labeling in the marketing of multi-component cannabis products.

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Terpenes of the Genus Salvia: Cytotoxicity and Antitumoral Effects

Cited by 3 publications

References 110 publications

Optimization of Cardamom Fruit (Amomum compactum) Extraction Focused on Total Terpenoid Extraction and Cytotoxic Activity Using Response Surface Methodology

Optimization of Cardamom Fruit (Amomum compactum) Extraction Focused on Total Terpenoid Extraction and Cytotoxic Activity Using Response Surface Methodology

Glechomanamides A–C, Germacrane Sesquiterpenoids with an Unusual Δ⁸-7,12-Lactam Moiety from Salvia scapiformis and Their Antiangiogenic Activity

The impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar

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Terpenes of the Genus Salvia: Cytotoxicity and Antitumoral Effects

Cited by 3 publications

References 110 publications

Optimization of Cardamom Fruit (Amomum compactum) Extraction Focused on Total Terpenoid Extraction and Cytotoxic Activity Using Response Surface Methodology

Optimization of Cardamom Fruit (Amomum compactum) Extraction Focused on Total Terpenoid Extraction and Cytotoxic Activity Using Response Surface Methodology

Glechomanamides A–C, Germacrane Sesquiterpenoids with an Unusual Δ8-7,12-Lactam Moiety from Salvia scapiformis and Their Antiangiogenic Activity

The impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar

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Glechomanamides A–C, Germacrane Sesquiterpenoids with an Unusual Δ⁸-7,12-Lactam Moiety from Salvia scapiformis and Their Antiangiogenic Activity