Terpenes extracted from marine sponges with antioxidant activity: a systematic review

Abstract

Marine biodiversity has emerged as a very promising resource of bioactive compounds and secondary metabolites from different sea organisms. The sponge’s secondary metabolites demonstrated various bioactivities and potential pharmacological properties. This systematic review of the literature focuses on the advances achieved in the antioxidant potential of marine sponges in vitro. The review was performed in accordance with PRISMA guidelines. The main inclusion criterion for analysis was articles with identification of compounds from terpene classes that demonstrate antioxidant activity in vitro. Searching in three different databases, two hundred articles were selected. After screening abstracts, titles and evaluating for eligibility of manuscripts 14 articles were included. The most performed analyzes to detect antioxidant activity were scavenging activity 2,2-diphenyl-1-picrylhydrazyl (DPPH) and measurement of intracellular reactive oxygen species (ROS). It was possible to identify 17 compounds of the terpene class with pronounced antioxidant activity in vitro. Scientific evidence of the studies included in this review was accessed by the GRADE analysis. Terpenes play an important ecological role, moreover these molecules have a pharmaceutical and industrial application. Graphical Abstract

Effect of Microfluidization on the Volatiles and Antibacterial, Antifungal, and Cytotoxic Activities of Algerian Satureja hortensis L. Oil-Loaded Nanoemulsions: In Vitro and In Silico Study

“…The obtained IC 50 values were in the order BHT < ASHEO ( Figure 8 ). The potent antioxidant activity of ASHEO could be attributed to its high terpene content, 45 mainly monoterpene hydrocarbons and oxygenated monoterpenes, as determined earlier. These compounds can donate protons to stabilize free radicals.…”

Cerium–Luteolin Nanocomplexes in Managing Inflammation-Related Diseases by Antioxidant and Immunoregulation

“…Besides the two mimicking enzyme activities, CeLutNCs were able to scavenge more than 48% of • OH with a concentration up to 160 μg mL –1 (Figure d). To further investigate the ROS-eliminating capabilities of CeLutNCs, the total ROS scavenging ability was assessed using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH • ), a nitrogen radical containing a number of unpaired electrons . As depicted in Figure e, more than 83% of DPPH • was eliminated by a very low concentration of CeLutNCs (20 μg mL –1 ).…”

Marine natural products and human immunity: novel biomedical resources for anti-infection of SARS-CoV-2 and related cardiovascular disease

“…In recent years, a series of literatures published in Natural Products and Bioprospecting showed that MNPs including Ascidians [ 172 ], brown algae [ 173 ], invertebrates [ 174 ], soft corals [ 175 ], some marine animals and creatures (e.g., salmon, shrimp, trout, krill, crayfish, microalgae Heamatococcus pluvialis, Chlorococcum, Chlorella zofingiensis) [ 176 ], and marine sponges [ 177 ] have exhibited a strong antimicrobial activity [ 173 ], with important and potentially bioactive compounds [ 174 ], for example, Astaxanthin [ 176 ], Cembranoids [ 175 ], and Terpenes [ 177 ], and have a broad range of biological activities, and present a huge potential for the development of various drugs for its remarkable bioactivities against mNCDs (such as CVD, cancer, diabetes, neurodegenerative and immune disorders, and others) due to a series of anti-aging [ 178 ], antioxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-obese, anti-viral (COVID-19 infection), neuro- & nephro-protective, and fertility-enhancing properties. Here, this article also summarized MNPs-derived bioactive compounds and/or targets, their chemical structures, and related potentials on human diseases (Table 2 ).…”