An integer of the form Pmpxq " pm´2qx 2´p m´4qx 2 for an integer x, is called a generalized m-gonal number. For positive integers α 1 , . . . , αu and β 1 , . . . , βv, a mixed sum Φ " α 1 P 4 px 1 q`¨¨¨`αuP 4 pxuq`β 1 P 8 py 1 q`¨¨¨β v P 8 pyv q of generalized 4-and 8-gonal numbers is called universal if Φ " N has an integer solution for any nonnegative integer N . In this article, we prove that there are exactly 1271 proper universal mixed sums of generalized 4-and 8-gonal numbers. Furthermore, the "61-theorem" is proved, which states that an arbitrary mixed sum of generalized 4-and 8-gonal numbers is universal if and only if it represents the integers