Ternary cyclodextrin polyurethanes containing phosphate groups: Synthesis and complexation of ciprofloxacin

Moreira, Mirna Pereira; Andrade, George Ricardo Santana; Araújo, Márcia Valéria Gaspar de; Kubota, Tatiana; Gimenez, Iara F.

doi:10.1016/j.carbpol.2016.05.101

Cited by 19 publications

(6 citation statements)

References 33 publications

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“…This polymer developed was used to complex the delivering therapeutic agents such as antibiotic ciprofloxacin. It was observed an improvement of the drug release in the case of the drug-polymers complexation than that of the free drug [63].…”

Section: Cd-based Polyurethane Nssmentioning

confidence: 93%

“…Another study showed the capability of CD polyurethane to reduce the levels of natural product contaminants, particularly, Ochratoxin A (OTA) from spiked solutions between 1 and 10 μgL-1 [61]. Following the attracted considerable interest that these polymers have shown in their use for water purification systems [62] and drug delivery [63], there were further done several chemical modifications on the CD NSs. Even though the modified CD NSs were used to enhance the properties and usefulness of CD NSs, their characterization at the molecular level remained a challenge.…”

Section: Cd-based Polyurethane Nssmentioning

confidence: 99%

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Strategies to Develop Cyclodextrin-Based Nanosponges for Smart Drug Delivery

Hoti¹,

Appleton²,

Pedrazzo³

et al. 2022

Smart Drug Delivery

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In recent years, the development of various cyclodextrin (CD)-based nanosponges (NSs) has gained great importance in the controlled and-or targeted release of drugs due to their versatility and simple preparation. In this chapter, an introduction of different administration routes is explained. Further, different ways to obtain CD-NSs and their classification are shown with a brief explanation of the characterization of the inclusion complexes. Finally, illustrative examples in diverse processes or diseases will be reviewed and explained to demonstrate the potential of CD-NSs. Therefore, this division will serve to compile information on CD-NSs in recent years and to illustrate to readers how to generate and apply different derivatives of interest.

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Section: Cd-based Polyurethane Nssmentioning

confidence: 93%

Section: Cd-based Polyurethane Nssmentioning

confidence: 99%

Strategies to Develop Cyclodextrin-Based Nanosponges for Smart Drug Delivery

Hoti¹,

Appleton²,

Pedrazzo³

et al. 2022

Smart Drug Delivery

View full text Add to dashboard Cite

show abstract

“…To detect the formation of ICs between ABAME and CDs, samples were physicochemically characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), powder X-ray diffraction (XRD), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) [ 20 , 67 ].…”

Section: Methodsmentioning

confidence: 99%

In Silico Study, Physicochemical, and In Vitro Lipase Inhibitory Activity of α,β-Amyrenone Inclusion Complexes with Cyclodextrins

Oliveira

Menezes

Silva

et al. 2021

IJMS

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α,β-amyrenone (ABAME) is a triterpene derivative with many biological activities; however, its potential pharmacological use is hindered by its low solubility in water. In this context, the present work aimed to develop inclusion complexes (ICs) of ABAME with γ- and β-cyclodextrins (CD), which were systematically characterized through molecular modeling studies as well as FTIR, XRD, DSC, TGA, and SEM analyses. In vitro analyses of lipase activity were performed to evaluate possible anti-obesity properties. Molecular modeling studies indicated that the CD:ABAME ICs prepared at a 2:1 molar ratio would be more stable to the complexation process than those prepared at a 1:1 molar ratio. The physicochemical characterization showed strong evidence that corroborates with the in silico results, and the formation of ICs with CD was capable of inducing changes in ABAME physicochemical properties. ICs was shown to be a stronger inhibitor of lipase activity than Orlistat and to potentiate the inhibitory effects of ABAME on porcine pancreatic enzymes. In conclusion, a new pharmaceutical preparation with potentially improved physicochemical characteristics and inhibitory activity toward lipases was developed in this study, which could prove to be a promising ingredient for future formulations.

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“…The tested ciprofloxacin/polyurethane films showed antibacterial activity against S. aureus , Sarcina lutea , B. cereus , and B. subtilis , as well as Gram-negative bacteria E. coli and P. aeruginosa . Novel ternary polyurethanes simultaneously containing β-CD and β-glycerophosphate groups (calcium salt, Ca-Glic, or H-Glic) cross-linked by HDI have been designed, using the properties of both polyalcohols: the inclusion capacity of β-CD toward hydrophobic drug molecules and the bioactivity of β-glycerophosphate [ 159 ]. The results showed that the CD cavities remained active toward the inclusion of guest molecules.…”

Section: Modern Drug-delivery Systemsmentioning

confidence: 99%

Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery Systems—A Pharmaceutical Perspective

Boczar

Michalska

2022

Pharmaceutics

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Cyclodextrins (CDs) are a family of cyclic oligosaccharides, consisting of a macrocyclic ring of glucose subunits linked by α-1,4 glycosidic bonds. The shape of CD molecules is similar to a truncated cone with a hydrophobic inner cavity and a hydrophilic surface, which allows the formation of inclusion complexes with various molecules. This review article summarises over 200 reports published by the end of 2021 that discuss the complexation of CDs with antibiotics and antibacterial agents, including beta-lactams, tetracyclines, quinolones, macrolides, aminoglycosides, glycopeptides, polypeptides, nitroimidazoles, and oxazolidinones. The review focuses on drug-delivery applications such as improving solubility, modifying the drug-release profile, slowing down the degradation of the drug, improving biological membrane permeability, and enhancing antimicrobial activity. In addition to simple drug/CD combinations, ternary systems with additional auxiliary substances have been described, as well as more sophisticated drug-delivery systems including nanosponges, nanofibres, nanoparticles, microparticles, liposomes, hydrogels, and macromolecules. Depending on the desired properties of the drug product, an accelerated or prolonged dissolution profile can be achieved when combining CD with antibiotics or antimicrobial agents.

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Ternary cyclodextrin polyurethanes containing phosphate groups: Synthesis and complexation of ciprofloxacin

Cited by 19 publications

References 33 publications

Strategies to Develop Cyclodextrin-Based Nanosponges for Smart Drug Delivery

Strategies to Develop Cyclodextrin-Based Nanosponges for Smart Drug Delivery

In Silico Study, Physicochemical, and In Vitro Lipase Inhibitory Activity of α,β-Amyrenone Inclusion Complexes with Cyclodextrins

Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery Systems—A Pharmaceutical Perspective

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