Ternary Cobalt (II)-Metformin-Glycine/Histidine/Proline Complexes: Multispectroscopic DNA, HSA, and BSA Interaction and Cytotoxicity Studies

Jayasri, B; Rajeshwari, K.; Vasantha, P.; Lakshmi, P. V. Anantha

doi:10.1007/s12011-023-03606-2

Cited by 3 publications

(4 citation statements)

References 59 publications

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“…As explained by polyelectrolyte theory, nonelectrostatic contribution (K o t ) to the total binding constant (K b ) increases with [Na + ] and reaches 56.76%, 35.55%, and 46.71% at 0.1 M NaCl for the complexes ( 1 – 3 ), respectively. Instead, the contribution of the nonelectrostatic binding free energy (ΔG o t ) to the overall binding free energy change (ΔG o ) is significantly large (Table 9), that is, 96.31%, 93.30%, and 95.05%, at [Na + ] = 0.1 M for the complexes ( 1 – 3 ) accordingly, indicating that nonelectrostatic processes play a major role in the stabilization of DNA binding 33,34 . Based on polyelectrolyte theory, nonelectrostatic binding constant (K o t ) does not depend on the salt concentration.…”

Section: Resultsmentioning

confidence: 99%

“…Instead, the contribution of the nonelectrostatic binding free energy (ΔG o t ) to the overall binding free energy change (ΔG o ) is significantly large (Table 9), that is, 96.31%, 93.30%, and 95.05%, at [Na + ] = 0.1 M for the complexes (1-3) accordingly, indicating that nonelectrostatic processes play a major role in the stabilization of DNA binding. 33,34 Based on polyelectrolyte theory, nonelectrostatic binding constant (K o t ) does not depend on the salt concentration. It is also important to calculate the bound free energy change (ΔG o ) of electrostatic bound free energy (ΔG o pe ) and the nonelectrostatic bound free energy (ΔG o t ) of metal-DNA interactions.…”

Section: T a B L Ementioning

confidence: 99%

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Co (II), Ni (II), and Cu (II) ternary complexes with 2,6‐pyridinedicarboxylic acid: Thermal decomposition, DNA interaction, and biological activity studies

Swapna,

Jayasri,

Anantha Lakshmi

2024

Applied Organom Chemis

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Three novel ternary complexes [MII (PDA)(o‐phen)(H2O)] (MII = CoII, NiII, and CuII) were synthesized using 2,6‐pyridinedicarboxylicacid as a primary ligand and 1,10‐phenanthroline(o‐phen) as the auxiliary ligand and analyzed by FT‐IR, mass, UV–Vis, thermogravimetry analysis, and conductivity measurement data. Based on electronic spectral measurements, all three of the metal complexes were found to have octahedral stereochemistry. The way metal complexes interact with ct‐DNA was studied using various methods including absorption spectroscopy, fluorescence spectroscopy, and viscosity measurements. UV–Vis absorption technique has been used to explore the binding characteristics of M (II) complexes with ct‐DNA. The complexes bind to DNA via groove mode of binding, according to the spectral data. The salt‐dependent binding of ternary metal complexes to ct‐DNA has been studied by UV–Vis spectrophotometric titration experiment. Furthermore, gel electrophoresis is used to examine how the metal complexes interacted with the pBR322 DNA. The outcomes showed that these compounds can function as efficient DNA cleaving agents. Studies on the complexes' in vitro antibacterial activity demonstrated their importance and good antimicrobial activity at three distinct concentrations (50, 75, and 100 g/mL).

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Section: Resultsmentioning

confidence: 99%

Section: T a B L Ementioning

confidence: 99%

Co (II), Ni (II), and Cu (II) ternary complexes with 2,6‐pyridinedicarboxylic acid: Thermal decomposition, DNA interaction, and biological activity studies

Swapna,

Jayasri,

Anantha Lakshmi

2024

Applied Organom Chemis

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“…The luminescence intensities without and with the inclusion of a quencher, correspondingly, are represented in the above formula by F 0 and F. K q represents the biomolecular quenching rate coefficient, K SV represents the quenching constant, and τ 0 represents the mean life span of the biomolecule without the metal complex (quencher). The K SV and K q variables are exhibited in the table, while K q is substantially more than 10 10 M −1 S −1 , i.e., the greatest value that can be acquired at ambient temperature for gradient‐limited quenching over several solutions, the fluorescence quenching method is at first static, whereas when K q value smaller, the fluorescence quenching process is first dynamic 52 …”

Section: Resultsmentioning

confidence: 99%

“…The K SV and K q variables are exhibited in the table, while K q is substantially more than 10 10 M À1 S À1 , i.e., the greatest value that can be acquired at ambient temperature for gradient-limited quenching over several solutions, the fluorescence quenching method is at first static, whereas when K q value smaller, the fluorescence quenching process is first dynamic. 52…”

Section: Tryptophanyl Fluorescence Quenchingmentioning

confidence: 99%

Water soluble Zinc(II) complexes: Geometrical, thermal, DNA/HSA/BSA binding, and cytotoxicity studies

Jayasri,

Shekhar,

P.V.

2024

Applied Organom Chemis

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The ternary complexes of the zinc(II), [Zn(met)(gly)(Cl)2] (1), and [Zn(met)(hist)(Cl)2] (2) are synthesized and illustrated utilizing spectroscopic and analytical measurements, and the geometry of the complexes has been identified to be octahedral. The Coats Red fern approach was employed to enumerate the thermodynamic and kinetic variables for both the Zn(II) complexes' decomposition. The quantum chemical variables were estimated utilizing the molecular orbital conformations' energy distribution, which was derived from optimal geometric shapes to test the stabilization of both complexes. DNA‐binding investigations by UV–Vis absorption, fluorescence, and viscosity were all exploited to examine the bonding properties between Zn(II) complexes and ct‐DNA, and a groove mode of bonding was established. The interactions between complexes and BSA/HSA were investigated by employing absorption and emission spectroscopic methods. The results demonstrate that complexes have a powerful ability to diminish BSA and HSA luminescence intensity, and overall associating mode is predominantly a static quenching process.The cytotoxic effect of the two Zn(II) complexes was additionally examined in human breast adenocarcinoma (MCF‐7 and MDA‐MB‐231) cell lines by employing the MTT technique. The IC50 values for every cell line were derived. Each of the two complexes was functional in both cell lines.

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Synthesis, characterization, DNA binding, protein binding, antioxidant and anti microbial activity of tetrazole ring based complexes

Husain

Devi

Anupama

2023

Journal of Molecular Structure

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Ternary Cobalt (II)-Metformin-Glycine/Histidine/Proline Complexes: Multispectroscopic DNA, HSA, and BSA Interaction and Cytotoxicity Studies

Cited by 3 publications

References 59 publications

Co (II), Ni (II), and Cu (II) ternary complexes with 2,6‐pyridinedicarboxylic acid: Thermal decomposition, DNA interaction, and biological activity studies

Co (II), Ni (II), and Cu (II) ternary complexes with 2,6‐pyridinedicarboxylic acid: Thermal decomposition, DNA interaction, and biological activity studies

Water soluble Zinc(II) complexes: Geometrical, thermal, DNA/HSA/BSA binding, and cytotoxicity studies

Synthesis, characterization, DNA binding, protein binding, antioxidant and anti microbial activity of tetrazole ring based complexes

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