Terms used in patient safety related to medication: a literature review

Pintor-Mármol, Antonio; Baena, M. I.; Fajardo, Paloma C.; Sabater‐Hernández, Daniel; Sáez-Benito, Loreto; García-Cárdenas, María Victoria; Fikri-Benbrahim, Narjis; Azpilicueta, Inés; Faus, María José

doi:10.1002/pds.3296

Cited by 53 publications

(37 citation statements)

References 160 publications

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“…Our primary goal was to document the incidence of AEs in the practice of nuclear medicine using prospective data collection by nuclear medicine scientists, clear definitions of AEs, (16,17), and a known denominator (16,17). With this approach, we believe we have overcome the problem of underreporting of AEs because of the transient nature of these events, confusion in the terminology of AEs, anxiety about potential liability, the time to complete a report form, and the lack of relevant reporting forms (16)(17)(18)(19), although Cold pyp † , 99m Tc-sestamibi*, 99m Tc-tetrofosmin (2 patients)* *Judged as unlikely by study criteria, totaling 5 AEs; if 2 patients are noted as having had AEs, only one was deemed unlikely in this study.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Adverse Events to Radiopharmaceuticals from 2007 to 2011

Silberstein

2014

J Nucl Med

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Section: Discussionmentioning

confidence: 99%

Prevalence of Adverse Events to Radiopharmaceuticals from 2007 to 2011

Silberstein

2014

J Nucl Med

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“…These terms are often understood very differently depending on the individuals or professionals involved; their meaning also depends on the domain of use, whether this be clinical, regulatory, or even legal. 3 In addition, if the focus is on medication-related terms, confusion may arise from whether one is referring to the process of medication use, to the clinical outcomes of medication use, or to a combination of process and outcome. 3 As a pharmacist, I am first and foremost concerned with safety issues arising from medications that are given to my patients.…”

Section: Multiplicity Of Terms Related To Patient Safety: a Hindrancementioning

confidence: 99%

“…3 In addition, if the focus is on medication-related terms, confusion may arise from whether one is referring to the process of medication use, to the clinical outcomes of medication use, or to a combination of process and outcome. 3 As a pharmacist, I am first and foremost concerned with safety issues arising from medications that are given to my patients. Both proper and improper uses of medications have the potential to create significant burdens on the health care system, because of a patient's admission to hospital from a drug-related problem, increased length of stay, or increased morbidity and mortality.…”

Section: Multiplicity Of Terms Related To Patient Safety: a Hindrancementioning

confidence: 99%

Multiplicity of Terms Related to Patient Safety: A Hindrance to Progress

Perreault

2015

CJHP

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“…Even though definitions of DRMs vary in the literature (17)(18)(19), they include both outcomes below or beyond the optimal medication intended outcomes (20).…”

Section: Drug-related Morbiditiesmentioning

confidence: 99%

Inappropriate prescribing, non-adherence to long-term medications and related morbidities : Pharmacoepidemiological aspects

Hedna

2015

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Aim:The aim of this thesis is to estimate and analyse the burden of potentially inappropriate prescriptions (PIPs) in the elderly and non-adherence to long-term medications among adults across care settings, and to investigate how IUM is associated to DRMs. Methods:A meta-analysis summarised the previous evidence on the percentage of adverse drug reactions (ADRs) associated to IUM across healthcare settings (Study I). From a cohort in the general population, using medical records and register data, the prevalence of PIPs in the elderly and its association with ADRs were estimated retrospectively (Study II). From the same cohort, the factors associated with refill non-adherence to antihypertensive therapy, considering the use of multiple medications, and the association between non-adherence and sub-therapeutic effects (STEs) were investigated (Study III). A survey assessed the refill behaviour to antihypertensive, lipid lowering and oral antidiabetic medications (undersupply, adequate supply and oversupply), and its association with perceived ADRs and STEs (Study IV).Results: IUM was the cause 52% and 45% of ADRs occurring in adult outpatients and inpatients respectively. Across healthcare settings, 46% of the elderly refilled PIPs over a 6-month period;PIPs were considered the cause of 30% of all ADRs; and the elderly who were prescribed PIPs had increased odds to experience ADRs (OR 2.47, 95% CI 1.65-3.69). In total, 35% was nonadherent to the full multidrug therapy and 13% was non-adherent to any medication (complete vi non-adherence). Sociodemographic factors (working age and lower income) were associated with non-adherence to any medication, while clinical factors (use of specialised care, use of multiple medications, and being a new user) with non-adherence to the full multidrug therapy. STEs were associated with non-adherence to any medication a month prior to a healthcare visit (OR 3.27, 95% CI 1.27-8.49), but not with long-term measures of non-adherence. Among survey respondents, 22% of the medications were oversupplied and 12% were undersupplied. Inadequate refill behaviour was not associated with reporting ADRs or STEs (p<0.05). Conclusions:A large proportion of ADRs occurring in hospital is caused by IUM, but more knowledge is needed in other settings. PIPs are common in the elderly general population and associated with ADRs. Therefore decreasing PIPs could contribute towards ADR prevention.Considering the use of multiple medications may help to better understand the factors associated with non-adherence to a multidrug therapy for tailoring the interventions to patient needs.Monitoring the adherence prior to a healthcare visit may facilitate interpreting STEs. Yet, the absence of an association between long-term measures of refill non-adherence with clinical and perceived DRMs suggest the need to enhance the knowledge of this association in clinical practice.In summary, this thesis shows a significant potential for improvements of medication use and outcomes.Key words: Drug-related morbidity, medica...

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Terms used in patient safety related to medication: a literature review

Cited by 53 publications

References 160 publications

Prevalence of Adverse Events to Radiopharmaceuticals from 2007 to 2011

Prevalence of Adverse Events to Radiopharmaceuticals from 2007 to 2011

Multiplicity of Terms Related to Patient Safety: A Hindrance to Progress

Inappropriate prescribing, non-adherence to long-term medications and related morbidities : Pharmacoepidemiological aspects

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