Terminology for Vulvar Cytology Based on the Bethesda System

Jiménez-Ayala, Matías; Jiménez-Ayala, Beatriz

doi:10.1159/000326969

Cited by 10 publications

(7 citation statements)

References 9 publications

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“…This difficulty in obtaining sufficient material has also been discussed in the previous literature (Nauth and Boger, 1982a; Nauth et al , 1987; Dennerstein, 1988; Jimenez-Ayala and Jimenez-Ayala, 2002; Bae-Jump et al , 2007). Whether our brushing technique results in higher cellularity compared with other techniques with a spatula or blade is not clear because studies with different techniques do not use comparable analysing methods.…”

Section: Discussionmentioning

confidence: 67%

“…The accuracy of cytology largely depends on the presence of enough cells and the ability to recognise cellular and nuclear atypia. Various techniques for vulvar cytology have been described with disappointing results because of scarce cellularity so vulvar cytology is now far from being common practice (Dennerstein, 1968; Nauth and Boger, 1982a; Nauth and Schilke, 1982b; Kashimura et al , 1993; Levine et al , 2001; Jimenez-Ayala and Jimenez-Ayala, 2002; Bae-Jump et al , 2007). …”

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confidence: 99%

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Cytology of the vulva: feasibility and preliminary results of a new brush

et al. 2011

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Objective:Taking a biopsy is a standard procedure to make the correct diagnosis in patients with suspicious premalignant vulvar lesions. The use of a less invasive diagnostic tool as triage instrument to determine whether biopsy is necessary may improve patient comfort especially in patients with chronic vulvar disorders that may warrant consecutive biopsies. This study was conducted to investigate whether vulvar brush cytology is feasible and may be used to detect (pre)malignant vulvar lesions.Methods:A pilot study was performed with patients having clinically normal vulvar skin, lichen sclerosus (LS), usual or differentiated vulvar intraepithelial neoplasia or squamous cell carcinoma. A total of 65 smears were taken with the use of a vulvar brush and biopsies were performed for histopathological analysis.Results:Out of 65 smears, 17 (26%) were discarded because of poor cellularity. A total of 28 of 29 (97%) smears with a histological proven (pre)malignancy had a smear classified as ‘suspicious' or ‘uncertain'. Cytology classified 11 smears as ‘non-suspicious', of which 10 (91%) were indeed normal skin or LS. The accuracy, based on the presence of a lesion, for (pre)malignant lesions with the use of the brush showed a sensitivity of 97% and a negative predictive value of 88%.Conclusion:Vulvar brush cytology is feasible and may be a first step in the development of a triage instrument to determine whether subsequent biopsy of a clinically (pre)malignant lesion is necessary.

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Section: Discussionmentioning

confidence: 67%

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confidence: 99%

Cytology of the vulva: feasibility and preliminary results of a new brush

et al. 2011

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“…Various techniques for vulvar cytology have been described with varying results [99][100][101][102][103][104].…”

Section: Diagnostics Cytologymentioning

confidence: 99%

“…A scalpel blade [101][102][103][104] was used to scrape the surface cells, with sufficient cellularity to make a right diagnosis. Also premoistened cotton swabs were used to collect material; tumor cells were found in only 57% of the malignant lesions.…”

Section: Diagnostics Cytologymentioning

confidence: 99%

Prevention, identification and treatment of vulvar squamous (pre)malignancies: a review focusing on quality of care

Einden¹,

Avoort

Hullu

2013

Expert Review of Anticancer Therapy

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Vulvar squamous cell carcinoma, its precursor lesions (usual and differentiated vulvar intraepithelial neoplasia) and lichen sclerosus are rare diseases that may have a large impact on the lives of affected women and their partners. Proper identification is vital, but the lesions are sometimes difficult to diagnose because of their rarity and variety of symptoms. High quality of care and proper treatment is important in order to minimize the morbidity and mortality caused by these lesions. This review gives an outline of the latest insights regarding the current evidence in this area and unresolved issues. Additionally, it highlights the improvements that should be made in order to optimize prevention and identification of (pre-)malignant vulvar lesions and to increase the quality of care for these patients.

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“…We consider that the terminology proposed by the Japanese authors [9,10] points in the right direction, because it is based on the Bethesda System. There are some points of possible discussion, such as the names of the subclassification of the atypical endometrial cells (ATEC) as ATEC of undetermined significance (ATEC US) and ATEC cannot exclude atypical endometrial hyperplasia or more (ATEC-A).…”

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confidence: 99%

New Terminology for Intrauterine Endometrial Samples: A Group Study by the Japanese Society of Cytology

Jiménez-Ayala¹

2012

Acta Cytologica

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Terminology for Vulvar Cytology Based on the Bethesda System

Cited by 10 publications

References 9 publications

Cytology of the vulva: feasibility and preliminary results of a new brush

Cytology of the vulva: feasibility and preliminary results of a new brush

Prevention, identification and treatment of vulvar squamous (pre)malignancies: a review focusing on quality of care

New Terminology for Intrauterine Endometrial Samples: A Group Study by the Japanese Society of Cytology

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