Terminologia Histologica 10 years on: some disputable terms in need of discussion and recent developments

Varga, Ivan; Gálfiová, Paulína; Blanková, Alžběta; Konarik, Marek; Báča, Václav; Dvořáková, Vlasta; Musil, Vladimír; Turyna, Radovan; Klein, Martin

doi:10.1016/j.aanat.2019.07.005

Cited by 8 publications

(7 citation statements)

References 54 publications

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“…After some of the current problems and inconsistencies of TH have been addressed in the second edition (Neumann & Neumann, 2021, 2023; Varga et al, 2018, 2019, 2020), we hope that it will become a useful tool for a wider group of scientific and medical professionals.…”

Section: Discussionmentioning

confidence: 99%

“…After some of the current problems and inconsistencies of TH have been addressed in the second edition (Neumann & Neumann, 2021, 2023Varga et al, 2018Varga et al, , 2019Varga et al, , 2020, we hope that it will T A B L E 5 Orthographic corrections, including digraphs and endings, and declension of modifiers. The dentinoenamel junction appears twice in TH, once as junctio dentinoenamelea and once as junctio dentinoenameli.…”

Section: Statoconia -Aementioning

confidence: 99%

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Revisiting the Latin vocabulary of Terminologia Histologica: I. Nouns

Neumann,

Houle,

Russell

et al. 2024

Clinical Anatomy

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Almost 20% of the Latin nouns (193/993) in Terminologia Histologica (TH), the international standard nomenclature for human histology and cytology, display linguistic problems, particularly in the areas of orthography, gender, and declension. Some anatomists have opposed efforts to restore the quality of the Latin nomenclature as pedantry, preferring to create or modify Latin words so that they resemble words in English and other modern languages. A Latin microanatomical nomenclature is vulnerable to the criticism of anachronism, so the requirement for the use of authentic Latin, including derivation of new words from Greek and Latin words rather than from modern languages, if possible, may be even greater than it is for the anatomical nomenclature. The most common problem identified here appears to have been caused by derivation of Latin nouns by addition of ‐us and ‐um second declension endings to English words. Many Latin nouns (128) in TH contain one of six morphemes that have been treated this way even though the original Greek words are either first declension masculine or third declension neuter nouns. Ironically, deriving Latin nouns directly from Greek morphemes often results in words that look more familiar to speakers of Romance and Germanic languages than those derived indirectly through modern languages (e.g., astrocyte, collagene, dendrita, lipochroma, osteoclasta and telomere instead of astrocytus, collagenum, dendritum, lipochromum, osteoclastus, and telomerus).

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Section: Discussionmentioning

confidence: 99%

Section: Statoconia -Aementioning

confidence: 99%

Revisiting the Latin vocabulary of Terminologia Histologica: I. Nouns

Neumann,

Houle,

Russell

et al. 2024

Clinical Anatomy

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“…9,11,14,[27][28][29][30][31] However, despite the controversies regarding TCs, [9][10][11]32 they should be included in both the nomenclature and textbooks of histology. 33 Nevertheless, care should be taken on two-dimensional slices, as tangentially cut endothelial cells, or lymphatic capillaries, could generate false evidence of TCs. 8 CD34 is considered in almost all studies identifying TCs as a reliable marker, 9,10,29 despite the fact that some authors reported as 'fibrocytes' either CD34+ stromal cells 34 or CD34 + Vimentin + myelomonocytic descendants.…”

Section: Discussionmentioning

confidence: 99%

Lymphatic lacunae of the human eye conjunctiva embedded within a stroma containing CD34⁺ telocytes

Nicolescu

Rusu

Voinea

et al. 2020

J Cellular Molecular Medi

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An accurate identification of telocytes (TCs) was limited because of the heterogeneity of cell types expressing the markers attributed to TCs. Some endothelial lineage cells also could fit within the pattern of TCs. Such endothelial cells could line conjunctival lacunae previously assessed by laser confocal microscopy. We have been suggested that an accurate distinction of TCs from endothelial cells in the human eye conjunctiva could be achieved by use of CD31, CD34 and D2‐40 (podoplanin); and that the conjunctival lacunae are in fact lymphatic. We aimed as testing the hypothesis by an immunohistochemical study on human eye conjunctiva biopsy samples. Samples of human eye conjunctiva from 30 patients were evaluated immunohistochemically by use of the primary antibodies: CD34, D2‐40 and CD31. D2‐40 was equally expressed within epithelia and laminae propria. Basal epithelial cells were D2‐40 positive. Within the stromal compartment, the lymphatic marker D2‐40 labelled several lymphatic vessels. CD31 labelled both vascular and lymphatic endothelial cells within the lamina propria. When capillary lymphatics were tangentially cut, they gave the false appearance of telocytes. Blood endothelial cells expressed CD34, whereas lymphatic endothelial cells did not. Stromal CD34‐expressing cells/telocytes were found building a consistent pan‐stromal network which was equally CD31‐negative and D2‐40‐negative. The conjunctival lymphatic lacunae seem to represent a peculiar anatomic feature of eye conjunctiva. They are embedded within a CD34‐expressing stromal network of TCs. The negative expression of CD31 and D2‐40 should be tested when discriminating CD34‐expressing TCs.

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“…To the best of our knowledge, TCs are still not included in any histological textbook, histology curricula at the universities, or the official histological nomenclature Terminologia Histologica [73]. In our previous paper, we proposed to include TCs into the second edition of this official nomenclature and histology textbooks, so that TCs will become more widely known among scholars and students [74]. Some research teams have actively challenged previous experimental data on TCs in different organs.…”

Section: Controversies In Telocyte Researchmentioning

confidence: 99%

Cardiac Telocytes 16 Years on—What Have We Learned So Far, and How Close Are We to Routine Application of the Knowledge in Cardiovascular Regenerative Medicine?

Klein

Csöbönyeiová

Žiaran

et al. 2021

IJMS

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The regeneration of a diseased heart is one of the principal challenges of modern cardiovascular medicine. There has been ongoing research on stem-cell-based therapeutic approaches. A cell population called telocytes (TCs) described only 16 years ago largely contributed to the research area of cardiovascular regeneration. TCs are cells with small bodies and extremely long cytoplasmic projections called telopodes, described in all layers of the heart wall. Their functions include cell-to-cell signaling, stem-cell nursing, mechanical support, and immunoregulation, to name but a few. The functional derangement or quantitative loss of TCs has been implicated in the pathogenesis of myocardial infarction, heart failure, arrhythmias, and many other conditions. The exact pathomechanisms are still unknown, but the loss of regulative, integrative, and nursing functions of TCs may provide important clues. Therefore, a viable avenue in the future modern management of these conditions is TC-based cell therapy. TCs have been previously transplanted into a mouse model of myocardial infarction with promising results. Tandem transplantation with stem cells may provide additional benefit; however, many underresearched areas need to be addressed in future research before routine application of TC-based cell therapy in human subjects. These include the standardization of protocols for isolation, cultivation, and transplantation, quantitative optimization of TC transplants, cost-effectivity analysis, and many others.

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Terminologia Histologica 10 years on: some disputable terms in need of discussion and recent developments

Cited by 8 publications

References 54 publications

Revisiting the Latin vocabulary of Terminologia Histologica: I. Nouns

Revisiting the Latin vocabulary of Terminologia Histologica: I. Nouns

Lymphatic lacunae of the human eye conjunctiva embedded within a stroma containing CD34⁺ telocytes

Cardiac Telocytes 16 Years on—What Have We Learned So Far, and How Close Are We to Routine Application of the Knowledge in Cardiovascular Regenerative Medicine?

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Terminologia Histologica 10 years on: some disputable terms in need of discussion and recent developments

Cited by 8 publications

References 54 publications

Revisiting the Latin vocabulary of Terminologia Histologica: I. Nouns

Revisiting the Latin vocabulary of Terminologia Histologica: I. Nouns

Lymphatic lacunae of the human eye conjunctiva embedded within a stroma containing CD34+ telocytes

Cardiac Telocytes 16 Years on—What Have We Learned So Far, and How Close Are We to Routine Application of the Knowledge in Cardiovascular Regenerative Medicine?

Contact Info

Product

Resources

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Lymphatic lacunae of the human eye conjunctiva embedded within a stroma containing CD34⁺ telocytes