Termination of the ovarian cycle in a young mouse joined to an old mouse in parabiosis

Gubrii, I. B.; Reznikov, Alexander; Demchenko, V. N.; Butenko, G. M.

doi:10.1007/bf00840344

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2013

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“…This report provided evidence of an extension of lifespan, particularly for female pairings, of the older parabiont in heterochronic pairings compared with unpaired or isochronically paired animals. In the latter part of the 20th century, heterochronic parabiosis was used to study aspects of the physiology of aging, published largely in the Russian literature (Butenko & Gubrii, 1980, 1981Sidorenko et al, 1986;Gubrii et al, 1987;Butenko, 1990;Frol'kis et al, 1996).…”

Section: Th Centurymentioning

confidence: 99%

Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity

2013

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Summary Pairing two animals in parabiosis to test for systemic or circulatory factors from one animal affecting the other animal has been used in scientific studies for at least 150 years. These studies have led to advances in fields as diverse as endocrinology, immunology, and oncology. A variation on the technique, heterochronic parabiosis, whereby two animals of different ages are joined to test for systemic regulators of aspects of aging or age-related diseases also has almost a century-long scientific history. In this review, we focus on the history of heterochronic parabiosis, methodological considerations and caveats, and the major advances that have emerged from those studies, including recent advances in our understanding of stem cell aging.

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