Termination of Replication and Mechanisms of Heteroplasmy in Sturgeon Mitochondrial DNA

Корниенко, И. В.; Чеботарев, Д. А.; Makhotkin, M. A.; Grigoriev, Vadim; Ponomareva, Elena; Матишов, Г. Г.

doi:10.1134/s0026893319010060

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…A comparison of mtDNA sequences in sturgeon and conserved sequences of termination replication (TAS) sturgeons with changes in the number of consecutive duplicate sequences showed that they could form stable structures during mtDNA replication. In the mtDNA of sturgeons, the control region responsible for the termination of H-strand replication contains one to seven variable number tandem repeats (VNTRs) with a unit size of 78 to 83 bp [ 47 ]. The D-loop of sturgeon mtDNA differs from the human D-loop and contains more than one TAS; therefore, the termination of mtDNA replication cannot be explained by helicase activity alone.…”

Section: Resultsmentioning

confidence: 99%

“…The D-loop of sturgeon mtDNA differs from the human D-loop and contains more than one TAS; therefore, the termination of mtDNA replication cannot be explained by helicase activity alone. Additionally, it is not still determined why sturgeons exhibit a wide range of haplotypes differing in VNTR length and, correspondingly, in the number of TAS elements [ 47 ]. Kornienko et al [ 47 ] identified VNTR regions containing highly conserved sequences that terminate with a CAT triplet in all sturgeon species studied.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, it is not still determined why sturgeons exhibit a wide range of haplotypes differing in VNTR length and, correspondingly, in the number of TAS elements [ 47 ]. Kornienko et al [ 47 ] identified VNTR regions containing highly conserved sequences that terminate with a CAT triplet in all sturgeon species studied. TAS elements are located in repeating units that constitute the VNTR.…”

Section: Resultsmentioning

confidence: 99%

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Characterization of the mitochondrial Huso huso genome and new aspects of its organization in the presence of tandem repeats in 12S rRNA

Dadkhah,

Mianji,

Barzegar

et al. 2023

BMC Ecol Evo

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Background The sturgeon group has been economically significant worldwide due to caviar production. Sturgeons consist of 27 species in the world. Mitogenome data could be used to infer genetic diversity and investigate the evolutionary history of sturgeons. A limited number of complete mitogenomes in this family were sequenced. Here, we annotated the mitochondrial Huso huso genome, which revealed new aspects of this species. Results In this species, the mitochondrial genome consisted of 13 genes encoding proteins, 22tRNA and 2rRNA, and two non-coding regions that followed other vertebrates. In addition, H. huso had a pseudo-tRNA-Glu between ND6 and Cytb and a 52-nucleotide tandem repeat with two replications in 12S rRNA. This duplication event is probably related to the slipped strand during replication, which could remain in the strand due to mispairing during replication. Furthermore, an 82 bp repeat sequence with three replications was observed in the D-loop control region, which is usually visible in different species. Regulatory elements were also seen in the control region of the mitochondrial genome, which included termination sequences and conserved regulatory blocks. Genomic compounds showed the highest conservation in rRNA and tRNA, while protein-encoded genes and nonencoded regions had the highest divergence. The mitochondrial genome was phylogenetically assayed using 12 protein-encoding genes. Conclusions In H. huso sequencing, we identified a distinct genome organization relative to other species that have never been reported. In recent years, along with the advancement in sequencing identified more genome rearrangements. However, it is an essential aspect of researching the evolution of the mitochondrial genome that needs to be recognized.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Characterization of the mitochondrial Huso huso genome and new aspects of its organization in the presence of tandem repeats in 12S rRNA

Dadkhah,

Mianji,

Barzegar

et al. 2023

BMC Ecol Evo

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“…26 . Kornienko et al (2019) identi ed in all sturgeon species studied, VNTR regions contained highly conservative sequences that it terminate with an CAT triplet. TAS elements located in repeating units that constitute VNTR.…”

Section: Non-coding Regionsmentioning

confidence: 99%

Characterization of the mitochondrial Huso huso genome with new aspects into its organization with presence of tandem repeat in the 12SrRNA and tRNA-Glu

Dadkhah

Mianji

Barzegar

et al. 2021

Preprint

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The sturgeon group is an economically important group in the world due to the production of caviar, and they are also a suitable old species for researching on the evolution of the mitochondrial genome. In H.huso sequencing, we identified a distinct genome organization relative to other species that has never been reported before. In this specie, the mitochondrial genome consisted of 13 genes encoding proteins, 22tRNA and 2rRNA, and two non-coding regions that followed other vertebrates. In addition, H.huso had an pseudo tRNA-Glu between ND6 and Cytb and also had a 52-nucleotide tandem repeat with two replications in the 12SrRNA. This duplication event is related to the slipped strand during replication, which can remain in the strand as a result of mispairing during replication. Furthermore, an 82 bp repeat sequence with three replications was observed in the D-loop control region, which is usually visible in different species. Regulatory elements are also visible in the control region of the mitochondrial genome that include termination sequences and conserved regulatory blocks. Genomic compounds showed the highest conservation in terms of rRNA and tRNA, while protein-encoded genes and non-encoded regions had the highest divergence. The mitochondrial genome was phylogenetically assayed using 13 protein-encoding genes.

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Next-generation sequencing reveals the mitogenomic heteroplasmy in the topmouth culter (Culter alburnus Basilewsky, 1855)

Xie

2021

Mol Biol Rep

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Termination of Replication and Mechanisms of Heteroplasmy in Sturgeon Mitochondrial DNA

Cited by 4 publications

References 19 publications

Characterization of the mitochondrial Huso huso genome and new aspects of its organization in the presence of tandem repeats in 12S rRNA

Characterization of the mitochondrial Huso huso genome and new aspects of its organization in the presence of tandem repeats in 12S rRNA

Characterization of the mitochondrial Huso huso genome with new aspects into its organization with presence of tandem repeat in the 12SrRNA and tRNA-Glu

Next-generation sequencing reveals the mitogenomic heteroplasmy in the topmouth culter (Culter alburnus Basilewsky, 1855)

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