Termination of early pregnancy (menstrual induction) with 16-phenoxy-ω-tetranor PGE2 methylsulfonylamide

Karim, S. M. M.; Rao, B. K.; Ratnam, S. S.; Prasad, Rajendra; Wong, YL; Ilancheran, A.

doi:10.1016/0010-7824(77)90049-x

Cited by 35 publications

(4 citation statements)

References 2 publications

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“…Medical methods emerged as an alternative to surgical abortion with the discovery of prostaglandins in the early 1970s [1][2][3]. Their use has evolved in the last two decades and various drugs have been used for first trimester medical abortion.…”

Section: Introductionmentioning

confidence: 99%

Medical termination for pregnancy in early first trimester (≤ 63 days) using combination of mifepristone and misoprostol or misoprostol alone: a systematic review

et al. 2020

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Background: A wide range of drugs have been studied for first trimester medical abortion. Studies evaluating different regimens, including combination mifepristone and misoprostol and misoprostol alone regimens, show varying results related to safety, efficacy and other outcomes. Thus, the objectives of this systematic review were to compare the safety, effectiveness and acceptability of medical abortion and to compare medical with surgical methods of abortion ≤63 days of gestation. Methods: Pubmed and EMBASE were systematically searched from database inception through January 2019 using a combination of MeSH, keywords and text words. Randomized controlled trials on induced abortion at ≤63 days that compared different regimens of medical abortion using mifepristone and/or misoprostol and trials that compared medical with surgical methods of abortion were included. We extracted data into a pre-designed form, calculated effect estimates, and performed meta-analyses where possible. The primary outcomes were ongoing pregnancy and successful abortion. Results: Thirty-three studies composed of 22,275 participants were included in this review. Combined regimens using mifepristone and misoprostol had lower rates of ongoing pregnancy, higher rates of successful abortion and satisfaction compared to misoprostol only regimens. In combined regimens, misoprostol 800 μg was more effective than 400 μg. There was no significant difference in dosing intervals between mifepristone and misoprostol and routes of misoprostol administration in combination or misoprostol alone regimens. The rate of serious adverse events was generally low.

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Section: Introductionmentioning

confidence: 99%

Medical termination for pregnancy in early first trimester (≤ 63 days) using combination of mifepristone and misoprostol or misoprostol alone: a systematic review

et al. 2020

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“…The results of these clinical trials [28][29][30][31][32][33][34] have been summarized by Bygdeman [32]. The most popular and promising analogues have been methylesters of 15-methyl-PGE 2 or F 2(X , 16-16-dimethyl-trans-A 2 -PGE, methylester and 16,16dimethyl-PGE 2 and 16-phenoxy-co-tetranor-PGE 2 methylsulphonamide.…”

Section: Medical Techniquesmentioning

confidence: 99%

“…By first administering Mefipristone in doses of 400-600 mg and following this by the Karim et al [28] Csapo and Pulkkinen [29] Caspo et al [30] Fleischer et al [31] Bygdeman et al [32] 16,16-dimethyl-PGE 2 MacKenzie et al [33] 16,16-dimethyl-PGE, methylester…”

Section: Combinations Of Antiprogesterone Preparations and Prostaglanmentioning

confidence: 99%

Abortion

Filshie¹

1989

Contraception

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“…Medical methods emerged as an alternative to surgical abortion with the discovery of prostaglandins in the early 1970s [1,2,3]. Their use has evolved in the last two decades and various drugs have been used for rst trimester medical abortion.…”

Section: Introductionmentioning

confidence: 99%

Medical termination for pregnancy in early first trimester (≤ 63 days) using combination of mifepristone and misoprostol or misoprostol alone: a systematic review

Abubeker

Lavelanet

Rodríguez

et al. 2020

Preprint

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Background: A wide range of drugs have been studied for first trimester medical abortion. Studies evaluating different regimens, including combination mifepristone and misoprostol and misoprostol alone regimens, show varying results related to safety, efficacy and other outcomes.Objectives: To compare the safety, effectiveness and acceptability of medical abortion and to compare medical methods with surgical methods of abortion ≤ 63 days of gestation. Methods: Pubmed and EMBASE were systematically searched from database inception through January 2019 using a combination of MeSH, keywords and text words. Randomized controlled trials on induced abortion at ≤ 63 days that compared different regimens of medical abortion using mifepristone and/or misoprostol and trials that compared medical with surgical methods of abortion were included. We extracted data into a pre‐designed form, calculated effect estimates, and performed meta‐analyses where possible. The primary outcomes were ongoing pregnancy and successful abortion. Results: Thirty-three studies composed of 22,275 participants were included in this review. Combined regimens using mifepristone and misoprostol had lower rates of ongoing pregnancy and higher rates of successful abortion compared to misoprostol only regimens. In combined regimens, misoprostol 800 μg was more effective than 400 μg. There was no significant difference in dosing intervals between mifepristone and misoprostol and routes of misoprostol administration in combination or misoprostol alone regimens. The rate of serious adverse events was generally low. Conclusion: In this systematic review, we find that medical methods of abortion utilizing combination mifepristone and misoprostol or misoprostol alone are effective, safe and acceptable. More robust studies evaluating both the different combination and misoprostol alone regimens are needed to strengthen existing evidence as well as assess patient perspectives towards a particular regimen.

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Termination of early pregnancy (menstrual induction) with 16-phenoxy-ω-tetranor PGE2 methylsulfonylamide

Cited by 35 publications

References 2 publications

Medical termination for pregnancy in early first trimester (≤ 63 days) using combination of mifepristone and misoprostol or misoprostol alone: a systematic review

Medical termination for pregnancy in early first trimester (≤ 63 days) using combination of mifepristone and misoprostol or misoprostol alone: a systematic review

Abortion

Medical termination for pregnancy in early first trimester (≤ 63 days) using combination of mifepristone and misoprostol or misoprostol alone: a systematic review

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