Terminating spiral waves with a single designed stimulus: Teleportation as the mechanism for defibrillation

DeTal, Noah; Kaboudian, Abouzar; Fenton, Flavio H.

doi:10.1073/pnas.2117568119

Cited by 17 publications

(10 citation statements)

References 58 publications

(85 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This motion and the associated spiral have a particular chirality, corresponding to a topological charge of +1 or −1. 67,68 Interestingly, spirals form and vanish only in pairs of +1 and −1 rotors. In addition, n-armed spirals are assigned topological charges of ± n and obey the same conservation constraint.…”

Section: The Journal Of Physical Chemistry Lettersmentioning

confidence: 99%

“…For instance, rotating spiral waves are organized by their central tip that, in simple cases, rotates along a small self-organized circular trajectory that remains stationary. This motion and the associated spiral have a particular chirality, corresponding to a topological charge of +1 or −1. , Interestingly, spirals form and vanish only in pairs of +1 and −1 rotors. In addition, n -armed spirals are assigned topological charges of ± n and obey the same conservation constraint.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Exploring the Synthesis of Self-Organization and Active Motion

Zhu,

Knoll,

Steinbock

2024

J. Phys. Chem. Lett.

View full text Add to dashboard Cite

Proteins, genetic material, and membranes are fundamental to all known organisms, yet these components alone do not constitute life. Life emerges from the dynamic processes of self-organization, assembly, and active motion, suggesting the existence of similar artificial systems. Against this backdrop, our Perspective explores a variety of chemical phenomena illustrating how nonequilibrium self-organization and micromotors contribute to life-like behavior and functionalities. After explaining key terms, we discuss specific examples including enzymatic motion, diffusiophoretic and bubble-driven self-propulsion, pattern-forming reaction-diffusion systems, self-assembling inorganic aggregates, and hierarchically emergent phenomena. We also provide a roadmap for combining self-organization and active motion and discuss possible outcomes through biological analogs. We suggest that this research direction, deeply rooted in physical chemistry, offers opportunities for further development with broad impacts on related sciences and technologies.

show abstract

Section: The Journal Of Physical Chemistry Lettersmentioning

confidence: 99%

mentioning

confidence: 99%

Exploring the Synthesis of Self-Organization and Active Motion

Zhu,

Knoll,

Steinbock

2024

J. Phys. Chem. Lett.

View full text Add to dashboard Cite

show abstract

“…Hence, in the biological context, the formation of spiral waves is often a sign of dysfunction. Consequently, in computational studies, various techniques have been used to terminate wave reentry, either by eliminating the stable rotor [12,13] or by making the spiral seed non-stationary [14], driving the rotor out of the medium.…”

Section: Introductionmentioning

confidence: 99%

Chirality and curvature determine the meandering of spirals in multilayer excitable media

Nezhad Hajian,

Parastesh,

Rajagopal

et al. 2023

Proc. R. Soc. A.

View full text Add to dashboard Cite

We study the emergence of meandering spiral waves in a multilayer structure where two spirals, originating independently, evolve in space–time. The FitzHugh-Nagumo model, enhanced with electromagnetic induction effects, defines the nodal dynamics. The layers are chemically coupled, and the drift of spirals is influenced by interlayer flux coupling. An external magnetic flux force is also necessary to destabilize and unpin spiral rotors. The effects of unique characteristics of spiral patterns, like chirality and tip curvature, are assessed. We find that spirals often drift within a bounded meandering area; however, determining the drift directions and overall meandering regions is complex. The forced spiral generally drifts a greater distance, except for identical co-rotating spirals, which drift synchronously. Spirals with opposite chirality exhibit asynchronous drift and wavefront asymmetry, even with identical tip curvature. Regardless of chirality, non-identical spirals are geometrically aligned and amplified before drifting. Stimulating the more loosely curved spiral ensures both spirals drift.

show abstract

“…In the last decades, cardiac research recognized computer models as fundamental tools in understanding both cardiac function and its response to external stimulation. Indeed, several recent computational studies focus on the development of carefully designed, low-energy stimulation strategy [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

A smoothed boundary bidomain model for cardiac simulations in anatomically detailed geometries

Biasi¹,

Seghetti²,

Mercati³

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

This manuscript presents a novel finite difference method to solve cardiac bidomain equations in anatomical models of the heart. The proposed method employs a smoothed boundary approach that represents the boundaries between the heart and the surrounding medium as a spatially diffuse interface of finite thickness. The bidomain boundary conditions are implicitly implemented in the smoothed boundary bidomain equations presented in the manuscript without the need of a structured mesh that explicitly tracks the heart-torso boundaries. We reported some significant examples assessing the method’s accuracy using nontrivial test geometries and demonstrating the applicability of the method to complex anatomically detailed human cardiac geometries. In particular, we showed that our approach could be employed to simulate cardiac defibrillation in a human left ventricle comprising fiber architecture. The main advantage of the proposed method is the possibility of implementing bidomain boundary conditions directly on voxel structures, which makes it attractive for three dimensional, patient specific simulations based on medical images. Moreover, given the ease of implementation, we believe that the proposed method could provide an interesting and feasible alternative to finite element methods, and could find application in future cardiac research guiding electrotherapy with computational models.

show abstract

Terminating spiral waves with a single designed stimulus: Teleportation as the mechanism for defibrillation

Cited by 17 publications

References 58 publications

Exploring the Synthesis of Self-Organization and Active Motion

Exploring the Synthesis of Self-Organization and Active Motion

Chirality and curvature determine the meandering of spirals in multilayer excitable media

A smoothed boundary bidomain model for cardiac simulations in anatomically detailed geometries

Contact Info

Product

Resources

About