Terminating arterial vessels in red pulp of human spleen: a trasmission electron microscopic study

Weiss, Leon; Powell, Rita Manco; Schiffman, Fred J.

doi:10.1007/bf02002618

Cited by 24 publications

(14 citation statements)

References 10 publications

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“…Previous studies have shown species differences in the structure of the spleen, particularly in relation to its vascular architecture (21). Concerning the vasculature of the human spleen, a number of papers have been published using light microscopy (LM) (20,21) and electron microscopy (EM) techniques (3)(4)(5)24). For example, Snook used LM to examine periodic acid-Schiff (PAS)-stained serial sections of human spleens and reported that the central artery running adjacent to a splenic follicle did not directly give off follicular arteries but ultimately divided into penicillar arteries to supply the red pulp of the spleen (21).…”

mentioning

confidence: 99%

Three-dimensional reconstruction of serial sections for analysis of the microvasculature of the white pulp and the marginal zone in the human spleen

Kusumi

Koga

Kanda³

et al. 2015

Biomed. Res.

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Although a number of papers have given useful information on splenic microcirculation by light and/or scanning electron microscopy, controversies remain as to the vascular arrangement, especially in the human spleen. The present study re-examined the microvasculature of the human spleen using a three-dimensional reconstruction of immunohistochemically stained tissue sections, and showed that the central artery does not directly issue follicular arteries in the human spleen; follicular arteries are derived from penicillar arteries outside the follicle and end in the white pulp. We found that the splenic follicle is surrounded by an elaborate system of anastomosed capillaries in both the marginal zone and the superficial layer of the white pulp. Most of these capillaries are also branches of the penicillar arterioles that are issued from the central artery in the same, or a different, white pulp system. Because the endothelia of these capillaries are widely open in the marginal zone, this vascular network may play a major role in supplying blood to the marginal zone. The accumulation of sialoadhesin-positive macrophages was also observed around the vascular network, suggesting an important role for this structure as the front line of immune response.

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confidence: 99%

Three-dimensional reconstruction of serial sections for analysis of the microvasculature of the white pulp and the marginal zone in the human spleen

Kusumi

Koga

Kanda³

et al. 2015

Biomed. Res.

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“…Only one other report exists for armadillos (Hayes). The sinusoids as well as fenestrate venules coexist, in this species, as occur in man (Weiss et al, 1985). The sinusoidal structure combined with the ability for a strong spleen contraction offer the possibility of a direct and rapid blood flux across the organ (Weiss, 1989).…”

Section: Discussionmentioning

confidence: 97%

The Spleen of a Specialy Adapted Mammal: The Little Hairy Armadillo Chaetophractus vellerosus, (Xenarthra, Dasypodidae). A Light and Electron Microscopic Study

2006

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The spleen of a specialy adapted mammal: The little hairy armadillo Chaetophractus vellerosus, (Xenarthra, Dasypodidae). A Light and electron microscopic study. Int. J. Morphol., 24(3):339-348, 2006. SUMMARY:The spleen is a multifunctional organ. Its microarchitecture reflects so well the phylogeny as the adaptation to niche in each animal group and inclusive in each species.Armadillos, as ancient and isolated mammals, show a mixture of ancestral and modern structures. In this work the microanatomy and cytology of the spleen of the little hairy armadillo Chaetophractus vellerosus was studied. The material was fixed and processed according to the typical methods for light and electron microscopy.Results show a cumulative medium sized spleen with the typical pulps. The white pulp is well developed but less defined than in other armadillos. The presence of follicular-dendritic-like cells and interdigitant dendritic-like cells, as well as clusters of immunocompetent cells agrees with an active immunological activity. The red pulp is a meshwork of circulatory spaces and cells. The presence of splenic sinusoids is recognized for the first time in the genus. Hemopoietic tissue is less developed than in other Euphractini. The microarchitecture and size of the spleen of C. vellerosus is discussed in a phylogenetic and adaptive context.

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“…The spleen contains a substantial population of both fixed and mobile macrophages together with lymphocytes within the splenic white pulp. Endothelial cells line the extensive sinusoidal network which forms the microvasculature of the spleen and platelets may be distributed both within the sinusoidal network and outside in the red and white pulp (Fujita et al, 1-985;Weiss et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

Modulation by endogenous prostanoids of the vasoconstrictor activity of endothelin‐1 in the canine isolated, perfused spleen

Kassisse

Antunes

Withrington

et al. 1994

British J Pharmacology

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1 Endothelin-l was injected into the arterial circuit of the isolated perfused spleen of the dog in which splenic arterial perfusion pressure and spleen weight were recorded continuously. 2 Serial collection was made of splenic venous effluent before and after intra-arterial injection of ET-l and assayed by direct radioimmunoassay for prostaglandin E2 (PGE2), 6-oxo-PGFI. and thromboxane B2 (TXB2). 3 ET-l caused graded arterial vasoconstriction of prolonged duration with small reductions in spleen weight at higher doses. 4 ET-l cause a dose-related release of PGE2, 6-oxo-PGFIr. and TXB2 into the splenic venous effluent.The mean peak increase above the basal levels following 200 pmol of ET-l was 800% for PGE2, 233%for 6-oxo-PGFIc and 205% for TXB2-5 Intra-arterial infusion of indomethacin significantly reduced the basal release of all three eicosanoids and significantly elevated the basal splenic vascular resistance. The release of all three eicosanoids in response to ET-1 and adrenaline (Ad) was significantly reduced by indomethacin and the accompanying increases in the splenic arterial vascular resistance were significantly potentiated at low doses of ET-1. The splenic arterial vascular responses to Ad were unchanged by indomethacin infusion. 6 These results indicate that the release of eicosanoids may modulate the splenic vascular responses to ET-1.

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Terminating arterial vessels in red pulp of human spleen: a trasmission electron microscopic study

Cited by 24 publications

References 10 publications

<b>Three-dimensional reconstruction of serial sections for analysis of the microvasculature of the white pulp and the marginal zone in the human </b><b>spleen </b>

<b>Three-dimensional reconstruction of serial sections for analysis of the microvasculature of the white pulp and the marginal zone in the human </b><b>spleen </b>

The Spleen of a Specialy Adapted Mammal: The Little Hairy Armadillo Chaetophractus vellerosus, (Xenarthra, Dasypodidae). A Light and Electron Microscopic Study

Modulation by endogenous prostanoids of the vasoconstrictor activity of endothelin‐1 in the canine isolated, perfused spleen

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