Terminally differentiated cytotoxic CD4+ T cells were clonally expanded in the brain lesion of radiation‐induced brain injury
Xueying Ma,
You Zuo,
Xia Hu
et al.
Abstract:BackgroundAccumulating evidence supports the involvement of adaptive immunity in the development of radiation‐induced brain injury (RIBI). Our previous work has emphasized the cytotoxic function of CD8+ T cells in RIBI. In this study, we aimed to investigate the presence and potential roles of cytotoxic CD4+ T cells (CD4+ CTLs) in RIBI to gain a more comprehensive understanding of adaptive immunity in this context.Main TextUtilizing single‐cell RNA sequencing (scRNA‐seq), we analyzed 3934 CD4+ T cells from the… Show more
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