Terminalia chebula Retz. – an important medicinal plant

Abstract

Summary Ayurveda, whispered to be the ancient practice of healthcare existed and contributes a holistic approach to health, healing and longevity. Terminalia chebula Retz. is a popular plant and widely spread all over southern Asia. T. chebula is a native plant of India and its dried fruit is extensively used in various types of home remedies. Dried fruit of T. chebula contains high quantities phenolic compounds that consist of ellagic acid, gallic acid and chebulic acid. The fruit extract of T. chebula is known to display different biological properties like anticancer, anti-inflammatory, antioxidant, anti-protozoal, antimicrobial, hepato and renal protective activities, and in the management of metabolic syndrome. The phenolic active compounds might play vital role in the influence of biological activity. Fruit extract of T. chebula is widely employed as an important ingredient in various ayurvedic preparations like ‘Triphala’. This formulation is beneficial as detoxifying agent of the colon, purgative in chronic constipation, aids in digestion and as a body rejuvenator. The fruit has great medicinal significance and conventionally applied for the management of various illness conditions, such as sore throat, high cough, asthma, ulcers, gout, heart burn, vomiting, diarrhea, dysentery, bleeding piles and bladder diseases. It is also utilized as mild laxative, antispasmodic and stomachic. Because of these enormous medicinal properties, T. chebula is commonly termed as ‘King of Medicine’ in Tibet and can be called as a ‘wonder herb’. In the present review, recent advances in medicinal properties of T. chebula are discussed.

Herbal Decoction Divya-Peedantak-Kwath Alleviates Allodynia and Hyperalgesia in Mice Model of Chemotherapy-Induced Peripheral Neuropathy via Modulation in Cytokine Response

“…Our observations indicate that DPK alleviates oxidative stress and prohibits inflammatory response. R. communis ( Abdul et al, 2018 ), T. chebula ( Bag et al, 2013 ; Kolla et al, 2018 ), T. ammi ( Ranjan et al, 2011 ; Bairwa et al, 2012 ), W. somnifera ( Dar et al, 2016 ), A. speciosa ( Joseph et al, 2011 ), C. deodara ( Gupta et al, 2011 ), V. negundo ( Gill et al, 2018 ), N. arbor-tristis ( Hussain and Ramteke, 2012 ), T. cordifolia ( Ghosh and Saha, 2012 ; Khan et al, 2016 ), C. fistula ( Kumar et al, 2017 ; Pawar et al, 2017 ), C. sativum ( Mahendra and Bisht, 2011 ; Rajeshwari and Andallu, 2011 ), F. vulgare ( Rahimi and Ardekani, 2013 ), Z. officinale ( Shakya, 2015 ), S. indicum ( Sharma et al, 2017 ), and S. surattense ( Tekuri et al, 2019 ) are rich in phytochemicals having high antioxidant potentials. G. herbaceum ( Khaleequr et al, 2012 ) has antioxidant property, whereas P. retrofractum ( Kubo et al, 2013 ) has shown to have neurotrophic effects.…”

“…G. herbaceum ( Khaleequr et al, 2012 ) has antioxidant property, whereas P. retrofractum ( Kubo et al, 2013 ) has shown to have neurotrophic effects. Indeed, T. cordifolia ( Ghosh and Saha, 2012 ; Khan et al, 2016 ) and T. chebula ( Bag et al, 2013 ; Kolla et al, 2018 ), in addition to antioxidative property, have anti-inflammatory and immunomodulatory activities. R. communis is both an antioxidant and anti-inflammatory agent ( Abdul et al, 2018 ).…”

“…R. communis ( Abdul et al, 2018 ), T. chebula ( Bag et al, 2013 ; Kolla et al, 2018 ), ( Kolla et al, 2018 ), W. somnifera ( Dar et al, 2016 ), V. negundo ( Gill et al, 2018 ), C. deodara ( Gupta et al, 2011 ), P. longum ( Kumar et al, 2011 ), C. fistula ( Kumar et al, 2017 ), B. diffusa ( Mahesh et al, 2012 ), T. cordifolia ( Ghosh and Saha, 2012 ), S. indicum ( Sharma et al, 2017 ), P. lanceolate ( Srivastava and Shanker, 2012 ), and S. surattense ( Tekuri et al, 2019 ) have demonstrated anticancer activities mainly due to their antiproliferative and apoptotic effects on cancerous cells. C. zedoaria ( Lobo et al, 2008 ) and C. sativum ( Mahendra and Bisht, 2011 ; Rajeshwari and Andallu, 2011 ) have antimutagenic activities.…”

Preparation of Triphala Churna using the Ingredients Obtained from Local Market and Comparative Standardization

“…14 The fruit pericarp of Terminalia chebula showed Cytoprotective activity, cardio tonic activity, anti-mutagenic activity and antifungal properties. 15,16…”

Pharmacognostic evaluation of Terminalia chebula standard extracts and finished products

“…According to the World Health Organization (WHO), about 80% of the world population depends mainly on plant-based traditional medicine for their primary healthcare requirement 2 When screening a number of herbal medicinal plants, scientists were discovered that T. chebula (Combretaceae) is one of the most revered medicinal plants, possesses several medicinal values due to the presence of many kinds of phytochemical constituents. T. chebula has been extensively used in ayurvedic, Unani & homoeopathic medicine and has become the cynosure of modern medicine 3 T. chebula possesses a wide variety of activities like antimicrobial 4 , antioxidant 5 , anti-viral 6 , anticarcinogenic 7 , hypocholesterolemic 8 , radioprotective 9 , anti-spasmodic and anti-purgative 10 .…”