Terminalia bellirica (Gaertn.) roxb. (Bahera) in health and disease: A systematic and comprehensive review

Gupta, Ashutosh; Kumar, Ramesh; Bhattacharyya, Piyali; Bishayee, Anupam; Pandey, Abhay K.

doi:10.1016/j.phymed.2020.153278

Cited by 48 publications

(21 citation statements)

References 69 publications

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“…Due to a wide range of biological effects of EA, edible plants containing this phytochemical and its hydrolyzable derivatives, mainly ellagitannins, are a valuable source of EA for humans and belong to functional foods that promote health and may reduce the risk of disease [127,128]. Many species of medicinal plants used in traditional medicine around the world, including Traditional Chinese Medicine and Ayurveda, have been found to contain EA and ellagitannins [63,97,[129][130][131][132][133][134]. EA is currently used in the pharmaceutical and cosmetics industries.…”

Section: Chemical Properties and Natural Sources Of Eamentioning

confidence: 99%

Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential

Sharifi‐Rad

Quispe

Castillo

et al. 2022

Oxidative Medicine and Cellular Longevity

156

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Ellagic acid (EA) is a bioactive polyphenolic compound naturally occurring as secondary metabolite in many plant taxa. EA content is considerable in pomegranate (Punica granatum L.) and in wood and bark of some tree species. Structurally, EA is a dilactone of hexahydroxydiphenic acid (HHDP), a dimeric gallic acid derivative, produced mainly by hydrolysis of ellagitannins, a widely distributed group of secondary metabolites. EA is attracting attention due to its antioxidant, anti-inflammatory, antimutagenic, and antiproliferative properties. EA displayed pharmacological effects in various in vitro and in vivo model systems. Furthermore, EA has also been well documented for its antiallergic, antiatherosclerotic, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties. This review reports on the health-promoting effects of EA, along with possible mechanisms of its action in maintaining the health status, by summarizing the literature related to the therapeutic potential of this polyphenolic in the treatment of several human diseases.

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Section: Chemical Properties and Natural Sources Of Eamentioning

confidence: 99%

Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential

Sharifi‐Rad

Quispe

Castillo

et al. 2022

Oxidative Medicine and Cellular Longevity

156

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“…72 Evidence is accumulating which supports the inhibitory effects of TB extract on the growth of various tumors. 74 A recent study reported suppression activity of T bellirica seed extract and pure gallic acid against cancer cell lines, including HaCaT keratinocytes, tongue (Cal33, SCC-4, and SCC-25), and pharynx (FaDu) squamous cell carcinoma. 75 The gallic acid in the TB extract possessed potent antioxidant and antiproliferative activities which resulted in programmed cell death, suggesting promising pharmacological effects against oral squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory, Antinociceptive, and Antitumorigenesis Activities ofTerminalia Bellerica(Gaertn.) Roxb. in Animal Models

Takuathung

Jaijoy

Soonthornchareonnon

et al. 2022

Natural Product Communications

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Previous pharmacological research has demonstrated that Terminalia bellerica (Gaertn.) Roxb. (TB) extract possesses several pharmacological activities. However, there is scant evidence documenting the therapeutic activities of TB extract on inflammation, pain, and cancers. Our study examined the in vivo anti-inflammation, antinociception, and antitumorigenesis effects of TB extract and investigated possible mechanisms for those effects. Anti-inflammation activities of TB extract were evaluated using ethyl phenylpropiolate (EPP)- and arachidonic acid (AA)-induced ear edema models, a cotton pellet-induced granulation formation model, and a carrageenan-induced hind paw edema model. An antinociceptive property of TB extract was assessed using a formalin-induced nociception test. An anticarcinogenesis effect was investigated using a 7,12-dimethylbenz( a) anthracene (DMBA) and 12- O-tetradecanoylphorbol-13-acetate (TPA)-induced tumorigenesis model. In the study, TB extract exhibited significant anti-inflammatory effects against EPP-induced ear edema and carrageenan-induced hind paw edema in rats. However, the TB extract showed insignificant inhibitory activity against AA-induced ear edema and cotton pellet-induced granuloma. A dose-dependent decrease in analgesic activity was observed with TB extract evidenced by decreased licking time in formalin-induced pain in mice in both the early and late phases. TB extract also significantly inhibited DMBA/TPA-induced mouse skin tumorigenesis. In conclusion, TB extract possesses anti-inflammatory, analgesic, and anticarcinogenesis properties which act, at least in part, through inhibitory effects of inflammatory mediator production.

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“…A spasm is defined as a rapid spontaneous contraction of a muscle, a set of muscles, or a hollow body part like the heart. A spasmodic muscle shrinkage can be produced by several circumstances, such as dystonia (Gupta, Kumar, Bhattacharyya, et al, 2020). Ali et al (2012) determined the antispasmodic behavior of V. thapsus aerial part methanolic extract in potassium chloride-induced contraction and suggested that the active mechanism of the plant is probably facilitated by the calcium channels.…”

Section: Antispasmodic Activitymentioning

confidence: 99%

“….6 | Antidepressant and anxiolytic activity Depression is a mental complication-related problem identified by a pertinacious depressed state or lack of concentration during activities, leading to remarkable disruption in everyday life(Gupta, Kumar, Bhattacharyya, Bishayee, & Pandey, 2020). Elevated plus maze (EPM), light-dark model transition (LD), and Forced Swim Test (FST) were performed to explore the antidepressant and anxiolytic properties of leaf methanolic extract.…”

mentioning

confidence: 99%

Health‐promoting and disease‐mitigating potential of Verbascum thapsus L. (common mullein): A review

Gupta

Atkinson

Pandey

et al. 2022

Phytotherapy Research

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Medicinal plants represent rich sources of traditional medicines and numerous currently used medicines are either directly or indirectly derived from plants. Verbascum thapsus L. (great mullein or common mullein), a medicinal herb indigenous to northern Africa, western and central Asia, and Europe, has been brought to the Americas and Australia. It has been used as a medicine for lung, skin and throat disorders and has a long history of therapeutic importance, particularly as an astringent and calming agent. Presently, the dried leaves, flowers, various plant extracts and flower oil are used in several formulations within Indian traditional medicine. An extract taken from the roots is useful in minimizing toothache, and it also relieves stiffness and seizures.V. thapsus contains a wide variety of phytoconstituents, such as flavonoids, iridoid, phenylethanoid and phenylpropanoid glycosides, saponins, as well as vitamin C and minerals. The most valuable constituents are coumarin and hesperidin, which possess healing properties. Emerging literature based on experimental studies on V. thapsus demonstrates various biological and pharmacological properties, including antiviral, antioxidant, analgesic, sedative, anti-inflammatory, hypnotic, antibacterial, antifungal, as well as anticancer activities. The present review provides an updated, comprehensive, and critical evaluation of various health-promoting and disease-mitigating properties of V. thapsus.

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Terminalia bellirica (Gaertn.) roxb. (Bahera) in health and disease: A systematic and comprehensive review

Cited by 48 publications

References 69 publications

Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential

Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential

Anti-inflammatory, Antinociceptive, and Antitumorigenesis Activities ofTerminalia Bellerica(Gaertn.) Roxb. in Animal Models

Health‐promoting and disease‐mitigating potential of Verbascum thapsus L. (common mullein): A review

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