Terminalia arjuna (Roxb.) Wt. and Arn. : A Review

Paarakh, Padmaa M

doi:10.3923/ijp.2010.515.534

Cited by 38 publications

(10 citation statements)

References 38 publications

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“…By mechanisms yet unknown, we suggest that active ingredients in AETA can up‐regulate gene expression of the main antioxidant enzymes. A phytochemical evaluation of the bark of Arjuna shows that apart from arjunolic acid, arjunic acid, arjungenin, arjunglucoside and arjunolone, it also contains (+) catechin, (−) gallocatechin, (−) epicatechin, (−) epigallocatechin, β‐sitosterol, ellagic acid and casuarianin . The induction of antioxidant enzyme gene expression by polyphenols is well known, but the similar effect due to other major components of TA like arjunolic acid needs to be explored.…”

Section: Discussionmentioning

confidence: 99%

“…5 Arjuna [Terminalia arjuna Wight and Arn Family: Combretaceae] is extensively used in the Ayurveda (traditional Indian healthcare system) for multiple benefits. 6 Experiments conducted with the bark of Arjuna have been shown to possess hypolipidemic, hypocholesterolemic, antidiabetic and anti-inflammatory activity together with anticancer, antiulcer, antimutagenic and wound-healing properties. 7,8 It has been well established that OS plays an important role in many disorders where Arjuna is beneficial, and its antioxidant property may underlie its perceived benefits.…”

Section: Introductionmentioning

confidence: 99%

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Aqueous extract of Terminalia arjuna attenuates tert‐butyl hydroperoxide–induced oxidative stress in HepG2 cell model

Shivananjappa¹,

Mhasavade²,

Joshi

2012

Cell Biochemistry & Function

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Arjuna (Terminalia arjuna) is a medicinal plant used in many polyherbal hepatoprotective formulations. Although widely claimed to be antioxidant, data supporting such actions of Arjuna are limited. In the present study, we have investigated the efficacy of the aqueous extract of T. arjuna (AETA) using a standard pro-oxidant [tertiary butyl hydroperoxide (TBHP)] in HepG2 cells. Cells were incubated with AETA (5-100 µg/ml) for a range of time points (4-24 h) with or without TBHP (500 μM), and biochemical markers of oxidative stress (OS) were determined. Cells incubated with TBHP showed the significant induction of OS response in cytosol manifested as lipid hydroperoxide (76%-198%) and the generation of reactive oxygen species (60%-127%). Diminished levels of reduced glutathione (35%-60%) and total antioxidant capacity (20%-61%) suggested an altered redox state. Significant perturbations in the activities of antioxidant enzymes such as catalase (30%-56%), superoxide dismutase (25%-68%), glutathione S-transferase (29%-67%), glutathione peroxidase (24%-68%) and glutathione reductase (38%-49%) were discernible suggesting the ongoing OS in the cells. However, cells treated with AETA (100 µg/ml) along with TBHP offered significant protection by reducing levels of lipid hydroperoxide (33%-62%) and ROS (69%) and by increasing antioxidant capacity (54%-81%) and levels of reduced glutathione (49%-82%). Further, it also enhanced the activities of endogenous antioxidant enzymes (superoxide dismutase, 60%; catalase, 35%-82%; glutathione peroxidase, 42-65 %; glutathione reductase, 48%-62%; and glutathione S-transferase, 22%-100%). Taken together, these data suggest that Arjuna can protect against the oxidative damage induced by TBHP and may be effectively used as a hepatoprotective adjuvant to abrogate OS in vivo.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aqueous extract of Terminalia arjuna attenuates tert‐butyl hydroperoxide–induced oxidative stress in HepG2 cell model

Shivananjappa¹,

Mhasavade²,

Joshi

2012

Cell Biochemistry & Function

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“…The synthetic medicines are having some lacunae owing to their side effects, but the inherent properties of herbal drugs have increased so as to fill the lacunae created by synthetic medicines. (3) The scientists are exploring the possibilities of utilizing pharmacologically active compounds from the medicinal herbs (4) . C. mukul is a small thorny plant (Fig:1), flowers are red, fruit is oval in shape and pulpy in nature.…”

Section: Introductionmentioning

confidence: 99%

A Review on Bioactive Phytoconstituents and Pharmacological Uses of Commiphora mukul.

Kalshetti¹,

Thakurdesai²,

Alluri³

2014

JCPR

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Commiphora mukul possesses a vast ethno medical history and represents a photochemical reservoir of heuristic medical value. It is one of the key ingredient in various treatment procedures. C. mukul contains a wide variety of chemical constituents such as monoterpenoids, diterpenoids, triterpenoids, steroids, sesquiterpenoids and volatil oil. Aim of the review is based on comprehensive review of traditional uses, phytochemistry, pharmacological and toxicological data on genus Commiphora, the future research and development to be planned. The need to review this plant is in order to provide scientific proof for its application in traditional medicinal system. The active constituent of the guggulipid is guggulsterone. The extract of C. mukul is used to treat variety of disorders in human beings as dyslipidaemia, obesity, inflammation.

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“…The powder of stem bark was used for treatment of angina pectoris already in ancient times and its cardioprotective activity is the primary reason for regained interest in this plant (Dwivedi 2007). There are, however, other medicinal applications of T. arjuna bark extracts such as its being an astringent, aphrodisiac, tonic, or used in therapy of fractures, ulcers, diabetes, tumors, inflammation, skin disorders (Kumar 2014;Paarakh 2010). Some of these activities have already been experimentally approved, e.g., antioxidant and anticancer action (Jain et al 2009), or anti-inflammatory, imunomodulatory, and antinociceptive action (Halder et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Cough and Arabinogalactan Polysaccharide from the Bark of Terminalia Arjuna

Sivová

Bera

Ray

et al. 2016

Advances in Experimental Medicine and Biology

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In this work we investigated the antitussive activity of the medicinal tree Terminalia arjuna. We used the stem bark for extraction and preparation of water extracted isolate and its two fractions: acetone-soluble (TA-S) and acetone precipitated (TA-P) fraction. The presence of a pectic arabinogalactan was confirmed in TA-P fraction by chromatographic and spectroscopic analysis. The antitussive activity of samples was assessed after oral administration in a dose of 50 mg.kg(-1) in healthy guinea pigs, in which cough was elicited by inhalation of citric acid (0.3 mol/L) in body plethysmograph. The water extracted isolate showed a significant ability to decrease the number of cough efforts by 64.2 %; the antitussive activity on par with that of codeine phosphate. The TA-P fraction showed the antitussive activity of 54.8 %. In contrast, TA-S fraction had only a mild antitussive activity. No changes in in vivo airway resistance were noted. We conclude that arabinogalactan is an essential component of Terminalia arjuna that underlies its antitussive action.

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Terminalia arjuna (Roxb.) Wt. and Arn. : A Review

Cited by 38 publications

References 38 publications

Aqueous extract of Terminalia arjuna attenuates tert‐butyl hydroperoxide–induced oxidative stress in HepG2 cell model

Aqueous extract of Terminalia arjuna attenuates tert‐butyl hydroperoxide–induced oxidative stress in HepG2 cell model

A Review on Bioactive Phytoconstituents and Pharmacological Uses of Commiphora mukul.

Cough and Arabinogalactan Polysaccharide from the Bark of Terminalia Arjuna

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