2018
DOI: 10.1016/j.molcel.2018.03.004
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Terminal Uridylyltransferases Execute Programmed Clearance of Maternal Transcriptome in Vertebrate Embryos

Abstract: During the maternal-to-zygotic transition (MZT), maternal RNAs are actively degraded and replaced by newly synthesized zygotic transcripts in a highly coordinated manner. However, it remains largely unknown how maternal mRNA decay is triggered in early vertebrate embryos. Here, through genome-wide profiling of RNA abundance and 3' modification, we show that uridylation is induced at the onset of maternal mRNA clearance. The temporal control of uridylation is conserved in vertebrates. When the homologs of termi… Show more

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Cited by 87 publications
(120 citation statements)
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References 86 publications
(96 reference statements)
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“…)* (Bazzini et al, 2016) Not studied during the MZT D. rerio ∼70% (Aanes et al, 2011;Harvey et al, 2013) YBX1 (Sun et al, 2018) >25% (Aanes et al, 2011;Harvey et al, 2013;Mishima and Tomari, 2016) hnRNPA* (Despic et al, 2017) PUM* (Rabani et al, 2017) ARE-BP* (Rabani et al, 2017) miR-430 (Bazzini et al, 2012;Giraldez et al, 2006) Yes (DDX6?) (Bazzini et al, 2016;Mishima and Tomari, 2016) N 6 -methyladenosine (Zhao et al, 2017) Terminal uridylation (Chang et al, 2018) Xenopus Not studied FRGY2 (X. laevis) (Bouvet and Wolffe, 1994;Matsumoto et al, 1996) Not studied ARE-BP (X. laevis) (Voeltz and Steitz, 1998;Moraes et al, 2006) miR-427 (X. laevis) (Lund et al, 2009) Yes (DDX6? )* (X. laevis) (Bazzini et al, 2016) Terminal uri...…”
Section: Rna-binding Proteinsmentioning
confidence: 99%
“…)* (Bazzini et al, 2016) Not studied during the MZT D. rerio ∼70% (Aanes et al, 2011;Harvey et al, 2013) YBX1 (Sun et al, 2018) >25% (Aanes et al, 2011;Harvey et al, 2013;Mishima and Tomari, 2016) hnRNPA* (Despic et al, 2017) PUM* (Rabani et al, 2017) ARE-BP* (Rabani et al, 2017) miR-430 (Bazzini et al, 2012;Giraldez et al, 2006) Yes (DDX6?) (Bazzini et al, 2016;Mishima and Tomari, 2016) N 6 -methyladenosine (Zhao et al, 2017) Terminal uridylation (Chang et al, 2018) Xenopus Not studied FRGY2 (X. laevis) (Bouvet and Wolffe, 1994;Matsumoto et al, 1996) Not studied ARE-BP (X. laevis) (Voeltz and Steitz, 1998;Moraes et al, 2006) miR-427 (X. laevis) (Lund et al, 2009) Yes (DDX6? )* (X. laevis) (Bazzini et al, 2016) Terminal uri...…”
Section: Rna-binding Proteinsmentioning
confidence: 99%
“…mRNA stability is usually modulated by their 5′ cap and 3′ poly (A) tail length 9,10 . Recently, N6-methyladenosine (m 6 A), the most prevalent modification in eukaryotic mRNA, has been correlated with mRNA stability.…”
mentioning
confidence: 99%
“…Several recent studies demonstrated that uridylation is a key factor in germline development, early embryogenesis and differentiation [30,74]. The expression of TUT4/7 is elevated during embryogenesis, which indicates their importance in development.…”
Section: (E) the Role Of Mrna Uridylation In Developmentmentioning
confidence: 99%
“…Uridylation further regulates events after fertilization via targeting coding [74] as well as ncRNAs [107,108]. The early zygote is transcriptionally inactive and its gene expression is ruled by the maternal transcriptome pool of the oocyte, which is formed during folliculogenesis [109,110].…”
Section: (E) the Role Of Mrna Uridylation In Developmentmentioning
confidence: 99%
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