Terminal Unfolded Protein Responses-related genes predict prognosis and associate with proliferation and apoptosis in clear cell renal cell carcinoma
Riwei Yang,
Leqi Liang,
Shan Ao
et al.
Abstract:Background
Terminal unfolded protein response (TUPR), a self-destruct mechanism of cells, initiates when irreversible endoplasmic reticulum stress (ER stress) occurs and causes cell apoptosis. Current studies show that TUPR also leads to apoptosis in carcinoma, which plays an indispensable role in development of tumors. However, understanding the specific role of TUPR in ccRCC cells is important for the treatment of tumors.
Methods
Based on 9 TUPR-associated genes, clusters of ccRCC patients were identified by… Show more
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