Terminal regions of a protein are a hotspot for low complexity regions and selection
Lokdeep Teekas,
Sandhya Sharma,
Nagarjun Vijay
Abstract:Volatile low complexity regions (LCRs) are a novel source of adaptive variation, functional diversification and evolutionary novelty. An interplay of selection and mutation governs the composition and length of low complexity regions. High %GC and mutations provide length variability because of mechanisms like replication slippage. Owing to the complex dynamics between selection and mutation, we need a better understanding of their coexistence. Our findings underscore that positively selected sites (PSS) and l… Show more
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