Teriparatide versus bisphosphonates for treatment of postmenopausal osteoporosis: A meta-analysis

miR-21-5p targets SKP2 to reduce osteoclastogenesis in a mouse model of osteoporosis

“…Bisphosphonates induce apoptosis in osteoclasts thereby decreasing bone transformation, making them an ideal treatment option; however, long-term use can lead to over-inhibition of bone remodelling and repair, resulting in excessive bone mineralisation and destruction of bone microstructure (6). Oestrogen is the most effective treatment strategy for postmenopausal females with osteoporosis; however, hormone replacement therapy is associated with adverse reactions in other systems.…”

“…Calcitonin is effective in preventing and healing of new pyramidal fractures but also associated with side effects including nausea, vomiting, and flushing, and hence it is commonly used as a second-line therapy to treat osteoporosis ( 5 ). Bisphosphonates induce apoptosis in osteoclasts, thereby decreasing bone transformation, making them an ideal treatment option; however, long-term use can lead to overinhibition of bone remodeling and repair, resulting in excessive bone mineralization and destruction of bone microstructure ( 6 ). Estrogen is the most effective treatment strategy for postmenopausal females with osteoporosis; however, hormone replacement therapy is associated with adverse reactions in other systems.…”

Effects of hip replacement combined with alendronate sodium on postoperative healing of osteoporotic femoral neck fracture and levels of CTX‑1 and BALP in patients

“…However, recent findings have shown that some patients suffer from bone loss and osteolysis due to osteoporosis after surgery, which has an impact on the stability of the prosthesis after replacement, shortens the service life of the prosthesis, and leads to the failure of clinical treatment to meet expectations (10). Alendronate sodium, as a bone metabolism regulator, can inhibit bone absorption and improve bone mineral density, and it is widely used in clinical practice (11). There are few reports on the combined use of alendronate sodium and hip replacement in the treatment of osteoporotic femoral neck fracture.…”

Carbon-Ion Beam Irradiation Alone or in Combination with Zoledronic acid Effectively Kills Osteosarcoma Cells

“…These findings suggest that the carbon-ion beam irradiation in combination with ZOL has high potential to increase OSA cell death.Cancers 2020, 12, 698 2 of 15 increasing amount of evidence has demonstrated that high linear energy transfer (LET) carbon-ion radiation therapy is suitable for targeting many kinds of radioresistant tumors such as those associated with bone and soft tissue malignancies including OSA [9][10][11][12][13][14] because it primarily does not elicit cell cycle-and oxygen-dependent cell-killing effects; it also has a high potential to kill radiochemo-resistant cancer stem cells (CSCs) compared to low LET radiation [15][16][17][18][19]. However, although carbon ion beam radiotherapy treatment has yielded promising results, the prognosis of OSA still remains unsatisfactory; developing novel combinational therapeutic strategies to further improve overall survival is required.Bisphosphonates comprise the most important class of osteoclast-mediated bone resorption inhibitors and are used extensively for treating skeletal diseases such as postmenopausal osteoporosis and tumor-induced osteolysis [20,21]. Zoledronic acid (ZOL), a third-generation nitrogen-containing bisphosphonate, is an inhibitor of osteoclast-mediated bone resorption that has demonstrated efficacy in treating bone metastases in cancer patients with breast, prostate, lung, and other solid tumors [22][23][24].…”

“…Bisphosphonates comprise the most important class of osteoclast-mediated bone resorption inhibitors and are used extensively for treating skeletal diseases such as postmenopausal osteoporosis and tumor-induced osteolysis [20,21]. Zoledronic acid (ZOL), a third-generation nitrogen-containing bisphosphonate, is an inhibitor of osteoclast-mediated bone resorption that has demonstrated efficacy in treating bone metastases in cancer patients with breast, prostate, lung, and other solid tumors [22][23][24].…”