Teriparatide improves microarchitectural characteristics of peri-implant bone in orchiectomized rats

Gomes-Ferreira, Pedro Henrique Silva; Oliveira, Danila de; Frigério, Paula Buzo; Batista, Fábio Roberto de Souza; Grandfield, Kathryn; Okamoto, Roberta

doi:10.1007/s00198-020-05431-y

Cited by 12 publications

(8 citation statements)

References 38 publications

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“…Furthermore, the main advantage of bioglass is its ability to bond to bone tissue due to the formation of an interfacial layer of calcium phosphate [ 22 , 75 , 76 , 77 , 78 ] As the understanding of the bioglass structure is directly associated with the interaction mechanisms of the material with the fabric, the structural investigation of the particles was carried out through several characterization tests of the samples. SEM-FEG results showed changes in the physical characteristics of the particles, in which the functionalized groups had rounded edges and reduced sizes in relation to the bioglass sample before the sonication process, changes that were characteristic of the functionalization process [ 56 ]. The functionalization time of the sample is of paramount importance, as the increase in the sonication period of the bioglass promotes a decrease in the size of the particles and smoothing of the edges of the sample.…”

Section: Discussionmentioning

confidence: 99%

“…In the intragroup histomorphometric analysis over the period of 2 weeks, the groups did not differ statistically ( p > 0.05). Studies have shown that the local use of teriparatide intermittently and subcutaneously resulted in an increase in the amount of newly formed bone tissue [ 38 , 56 ]. Ozer et al [ 42 ] also addressed the local use of teriparatide with xenografts in rabbits and found that in periods of 4 and 8 weeks, the group with the presence of the drug showed higher mean values of new bone formation.…”

Section: Discussionmentioning

confidence: 99%

“…The animal was randomly divided into two groups, with 30 rats having undergone bilateral ovariectomy (OVX) and 15 rats having undergone simulated ovariectomy surgery (Sham). Thus, the experimental model adopted in the present project consisted of estrogen-deficient animals in the OVX group [ 18 , 56 , 57 , 58 ]. In each OVX and Sham group, critical 5.0 mm bone defects were made in the calvaries.…”

Section: Methodsmentioning

confidence: 99%

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The Local Release of Teriparatide Incorporated in 45S5 Bioglass Promotes a Beneficial Effect on Osteogenic Cells and Bone Repair in Calvarial Defects in Ovariectomized Rats

Araújo

Silva

Lima

et al. 2023

JFB

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With the increase in the population’s life expectancy, there has also been an increase in the rate of osteoporosis, which has expanded the search for strategies to regenerate bone tissue. The ultrasonic sonochemical technique was chosen for the functionalization of the 45S5 bioglass. The samples after the sonochemical process were divided into (a) functionalized bioglass (BG) and (b) functionalized bioglass with 10% teriparatide (BGT). Isolated mesenchymal cells (hMSC) from femurs of ovariectomized rats were differentiated into osteoblasts and submitted to in vitro tests. Bilateral ovariectomy (OVX) and sham ovariectomy (Sham) surgeries were performed in fifty-five female Wistar rats. After a period of 60 days, critical bone defects of 5.0 mm were created in the calvaria of these animals. For biomechanical evaluation, critical bone defects of 3.0 mm were performed in the tibias of some of these rats. The groups were divided into the clot (control) group, the BG group, and the BGT group. After the sonochemical process, the samples showed modified chemical topographic and morphological characteristics, indicating that the surface was chemically altered by the functionalization of the particles. The cell environment was conducive to cell adhesion and differentiation, and the BG and BGT groups did not show cytotoxicity. In addition, the experimental groups exhibited characteristics of new bone formation with the presence of bone tissue in both periods, with the BGT group and the OVX group statistically differing from the other groups (p < 0.05) in both periods. Local treatment with the drug teriparatide in ovariectomized animals promoted positive effects on bone tissue, and longitudinal studies should be carried out to provide additional information on the biological performance of the mutual action between the bioglass and the release of the drug teriparatide.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The Local Release of Teriparatide Incorporated in 45S5 Bioglass Promotes a Beneficial Effect on Osteogenic Cells and Bone Repair in Calvarial Defects in Ovariectomized Rats

Araújo

Silva

Lima

et al. 2023

JFB

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“…To evaluate the new bone around the implant, alizarin red (30 mg/kg; Sigma) and fluorochrome calcein (20 mg/kg; Sigma) were administered to each animal intramuscularly 2 and 3 weeks after surgery, respectively, as double-fluorescent labeling. 40 Hard tissue slices were generated to evaluate the bone-implant interface and calculate bone implant contact (BIC). Briefly, samples were dehydrated in a graded series of ethanol (70%, 90%, and 100%), embedded in resin, photopolymerized, and the tissue was cut by a tungsten steel knife on the slicer, then ground to an ideal position (approximately 10 μm thickness along the long axis of the implant) on the grinding machine.…”

Section: Methodsmentioning

confidence: 99%

Intraosseous Injection of Calcium Phosphate Polymer-Induced Liquid Precursor Increases Bone Density and Improves Early Implant Osseointegration in Ovariectomized Rats

Zhou¹,

Hu²,

Ge³

et al. 2021

IJN

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Purpose Osteoporosis, due to bone loss and structural deterioration, is a risk factor for dental implant failure, as it impedes initial stability and osseointegration. We aim to assess the effects of calcium phosphate polymer-induced liquid precursor (CaP-PILP) treatment, which significantly increases bone density and improves early implant osseointegration in ovariectomized rats. Methods In this study, CaP-PILP was synthesized and characterized through TEM, FTIR and XRD. A rat model of osteoporosis was generated by ovariectomy. CaP-PILP or hydroxyapatite (HAP, negative control) was injected into the tibia, and the resulting changes in bone quality were determined. Further, implants were installed in the treated tibias, and implantation characteristics were assessed after 4 weeks. Results The CaP-PILP group had superior bone repair. Importantly, CaP-PILP had excellent properties, similar to those of normal bone, in terms of implant osseointegration. In vivo experiment displayed that CaP-PILP group had better bone contact rate (65.97±3.176) than HAP and OVX groups. Meanwhile, a mound of mature and continuous new bone formed. Moreover, the values of BIC and BA showed no significant difference between the CaP-PILP group and the sham group. Conclusion In summary, CaP-PILP is a promising material for application in poor-quality bones to improve implant success rates in patients with osteoporosis. This research provides new perspectives on the application of nano-apatite materials in bone repair.

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“…iPTH treatment is critical for osteogenesis at the peri-implant area and for osseointegration at the external and internal surfaces of implants in aged rats and in osteoporosis animal models induced by ovariectomy, glucocorticoid, or low protein diet ( Dayer et al, 2010 ; Almagro et al, 2013 ; Oki et al, 2017 ; Park et al, 2017 ; Jiang et al, 2018 ). It is worth noting that treating jaw osteoporosis with PTH (1–34) before implant surgery restored bone quality, bone volume, and bone turnover, leading to favorable implant stability ( Gomes-Ferreira et al, 2020 ). Furthermore, PTH (1–34) can be used to reverse the deleterious effects of cigarette smoke such as poor bone healing and low bone mass in the bone-implant interface ( Lima et al, 2013 ).…”

Section: Therapeutic Application Of Parathyroid Hormone/parathyroid Hormone-related Protein In Orofacial Regionmentioning

confidence: 99%

Parathyroid Hormone 1 Receptor Signaling in Dental Mesenchymal Stem Cells: Basic and Clinical Implications

Lyu

et al. 2021

Front. Cell Dev. Biol.

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Parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) are two peptides that regulate mineral ion homeostasis, skeletal development, and bone turnover by activating parathyroid hormone 1 receptor (PTH1R). PTH1R signaling is of profound clinical interest for its potential to stimulate bone formation and regeneration. Recent pre-clinical animal studies and clinical trials have investigated the effects of PTH and PTHrP analogs in the orofacial region. Dental mesenchymal stem cells (MSCs) are targets of PTH1R signaling and have long been known as major factors in tissue repair and regeneration. Previous studies have begun to reveal important roles for PTH1R signaling in modulating the proliferation and differentiation of MSCs in the orofacial region. A better understanding of the molecular networks and underlying mechanisms for modulating MSCs in dental diseases will pave the way for the therapeutic applications of PTH and PTHrP in the future. Here we review recent studies involving dental MSCs, focusing on relationships with PTH1R. We also summarize recent basic and clinical observations of PTH and PTHrP treatment to help understand their use in MSCs-based dental and bone regeneration.

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Teriparatide improves microarchitectural characteristics of peri-implant bone in orchiectomized rats

Cited by 12 publications

References 38 publications

The Local Release of Teriparatide Incorporated in 45S5 Bioglass Promotes a Beneficial Effect on Osteogenic Cells and Bone Repair in Calvarial Defects in Ovariectomized Rats

The Local Release of Teriparatide Incorporated in 45S5 Bioglass Promotes a Beneficial Effect on Osteogenic Cells and Bone Repair in Calvarial Defects in Ovariectomized Rats

Intraosseous Injection of Calcium Phosphate Polymer-Induced Liquid Precursor Increases Bone Density and Improves Early Implant Osseointegration in Ovariectomized Rats

Parathyroid Hormone 1 Receptor Signaling in Dental Mesenchymal Stem Cells: Basic and Clinical Implications

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