Teriparatide and exercise improve bone, skeletal muscle, and fat parameters in ovariectomized and tail-suspended rats

Sato, Chiaki; Miyakoshi, Naohisa; Kasukawa, Yuji; Nozaka, Koji; Tsuchie, Hiroyuki; Nagahata, Itsuki; Yuasa, Yusuke; Abe, Kazunobu; Saito, Hikaru; Shoji, Ryo; Shimada, Yasuhiro

doi:10.1007/s00774-020-01184-0

Cited by 27 publications

(18 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 10 , 11 Teriparatide, a kind of parathyroid hormone, may have anabolic effects on skeletal muscle and adipose tissue in addition to bone. 12 Similarly, while vitamin D supplements may improve bone density, their effect on muscle mass and strength is still being researched. 13 A previous study showed that combining alendronate and calcitriol improved grip strength but had no discernible effect on muscle mass in postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

Retrospective Study of the Effects of Zoledronic Acid on Muscle Mass in Osteoporosis Patients

Huang¹,

Shiao²,

Mao³

2021

DDDT

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Retrospective Study of the Effects of Zoledronic Acid on Muscle Mass in Osteoporosis Patients

Huang¹,

Shiao²,

Mao³

2021

DDDT

View full text Add to dashboard Cite

“…The compression test of the distal part of the left femur was performed at room temperature using a material testing machine (MZ500S; Maruto, Tokyo, Japan) at 12, 16, and 20 weeks of age, as previously described [ [19] , [20] , [21] ]. Load-displacement curves were recorded, and the maximum load (N), stiffness (N/mm), and energy absorption (N.mm) were calculated using software for measuring bone strength (CTR win.…”

Section: Methodsmentioning

confidence: 99%

“…The excised right distal femurs from rats in the sham and CKD groups at 20 weeks of age were secured in a sample holder. Micro-CT was performed with CosmoScan GX II (Rigaku Corporation, Tokyo, Japan), according to the manufacturer's instructions, with an isotropic voxel size of 36 μm, energy of 90 kVp, and current of 88 μA, following the previous reports [ 20 , 22 ]. The captured images were rendered using TRI/3D BON software (Ratoc System Engineering Co., Ltd., Tokyo, Japan).…”

Section: Methodsmentioning

confidence: 99%

Analysis of bone in adenine-induced chronic kidney disease model rats

Saito

Miyakoshi

Kasukawa

et al. 2021

Osteoporosis and Sarcopenia

Self Cite

View full text Add to dashboard Cite

Objectives The purpose of this study is to investigate the stage of chronic kidney disease (CKD) in adenine-induced CKD model rats by serum analyses, and to examine bone mineral density (BMD), bone strength, and microstructure of trabecular and cortical bone in these rats. Methods Eight-week-old, male Wistar rats (n = 42) were divided into 2 groups: those fed a 0.75% adenine diet for 4 weeks until 12 weeks of age to generate CKD model rats (CKD group); and sham rats. The CKD and sham groups were sacrificed at 12, 16, and 20 weeks of age (n = 7 in each group and at 12, 16, and 20 weeks), and various parameters were evaluated, including body weight, renal wet weight, muscle wet weight, renal histology, biochemical tests, BMD, biomechanical testing, and micro-computed tomography (CT). The parameters were compared between the 2 groups at the various time points. Results In the CKD model rats, at 20 weeks of age, serum creatinine, phosphorus, and intact-PTH levels were elevated, and serum calcium levels were normal, indicating that the CKD was stage IV and associated with secondary hyperparathyroidism. Decreased BMDs of the whole body and the femur were observed as bone changes, and micro-CT analysis showed deterioration of bone microstructure of the cortical bone that resulted in decreased bone strength in the cortical and trabecular bone. Conclusions These CKD model rats showed stage IV CKD and appear appropriate for evaluating the effects of several treatments for CKD-related osteoporosis and mineral bone disorder.

show abstract

“…Skeletal muscles and bone metabolisms are closely related during development and growth, and their loss is a major clinical problem for the elderly population and a cause of falls and fragility fractures [29]. Their interactions are related to the endocrinological and metabolic interconnection of muscle and bone and adiposity in the bone marrow and muscles [30]. Muscle atrophy, osteoporosis, and fatty infiltration into bone marrow and skeletal muscle should be managed to prevent sarcopenia-induced falls and bone fractures [30].…”

Section: Overall View Of Muscle Metabolism and The Factors That Contr...mentioning

confidence: 99%

Sarcopenia Is a Cause and Consequence of Metabolic Dysregulation in Aging Humans: Effects of Gut Dysbiosis, Glucose Dysregulation, Diet and Lifestyle

Daily¹,

Park

2022

Cells

View full text Add to dashboard Cite

Skeletal muscle mass plays a critical role in a healthy lifespan by helping to regulate glucose homeostasis. As seen in sarcopenia, decreased skeletal muscle mass impairs glucose homeostasis, but it may also be caused by glucose dysregulation. Gut microbiota modulates lipopolysaccharide (LPS) production, short-chain fatty acids (SCFA), and various metabolites that affect the host metabolism, including skeletal muscle tissues, and may have a role in the sarcopenia etiology. Here, we aimed to review the relationship between skeletal muscle mass, glucose homeostasis, and gut microbiota, and the effect of consuming probiotics and prebiotics on the development and pathological consequences of sarcopenia in the aging human population. This review includes discussions about the effects of glucose metabolism and gut microbiota on skeletal muscle mass and sarcopenia and the interaction of dietary intake, physical activity, and gut microbiome to influence sarcopenia through modulating the gut–muscle axis. Emerging evidence suggests that the microbiome can regulate both skeletal muscle mass and function, in part through modulating the metabolisms of short-chain fatty acids and branch-chain amino acids that might act directly on muscle in humans or indirectly through the brain and liver. Dietary factors such as fats, proteins, and indigestible carbohydrates and lifestyle interventions such as exercise, smoking, and alcohol intake can both help and hinder the putative gut–muscle axis. The evidence presented in this review suggests that loss of muscle mass and function are not an inevitable consequence of the aging process, and that dietary and lifestyle interventions may prevent or delay sarcopenia.

show abstract

Teriparatide and exercise improve bone, skeletal muscle, and fat parameters in ovariectomized and tail-suspended rats

Cited by 27 publications

References 43 publications

Retrospective Study of the Effects of Zoledronic Acid on Muscle Mass in Osteoporosis Patients

Retrospective Study of the Effects of Zoledronic Acid on Muscle Mass in Osteoporosis Patients

Analysis of bone in adenine-induced chronic kidney disease model rats

Sarcopenia Is a Cause and Consequence of Metabolic Dysregulation in Aging Humans: Effects of Gut Dysbiosis, Glucose Dysregulation, Diet and Lifestyle

Contact Info

Product

Resources

About