Terfenadine and Fexofenadine Reduce in Vitro ICAM-1 Expression on Human Continuous Cell Lines

Paolieri, F.; Battifora, M.; Riccio, Anna Maria; Bertolini, C; Ciprandi, Giorgio; Canonica, Giorgio Walter; Bagnasco, Marcello; Cutolo, Maurizio; Bloom, M.

doi:10.1016/s1081-1206(10)62712-3

Cited by 66 publications

(40 citation statements)

References 25 publications

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“…20,22,33 The effect of fexofenadine on nasal congestion might reflect an activity that is broader than its antagonism at the H 1 -receptor. Numerous in vitro studies with fexofenadine have highlighted the potential of this agent to produce significant anti-inflammatory effects at clinically relevant concentrations, [34][35][36][37][38] and it is hypothesized that these effects might contribute to inhibition of the late-phase response. 37 In this large pediatric population, the incidence and severity of reported adverse events with fexofenadine were similar to those for placebo.…”

Section: Discussionmentioning

confidence: 99%

Fexofenadine is efficacious and safe in children (aged 6-11 years) with seasonal allergic rhinitis

Wahn¹,

Meltzer²,

Finn³

et al. 2003

Journal of Allergy and Clinical Immunology

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Background: This is the first prospective, randomized, doubleblind, placebo-controlled study showing statistical improvement of an H 1 -antihistamine in children with seasonal allergic rhinitis in all symptoms throughout the entire treatment period. Objective: This randomized, placebo-controlled, parallelgroup, double-blind study was performed to assess the efficacy and safety of fexofenadine in children with seasonal allergic rhinitis. Methods: This study was conducted at 148 centers in 15 countries. Nine hundred thirty-five children (aged 6-11 years) were randomized and treated with either fexofenadine HCl 30 mg (n = 464) or placebo (n = 471) tablets twice a day for 14 days. Individual symptoms (sneezing; rhinorrhea; itchy nose, mouth, throat, and/or ears; itchy, watery, and/or red eyes; and nasal congestion) were assessed at baseline and then daily at 7:00 AM and 7:00 PM (±1 hour) during the double-blind treatment period. Each total symptom score was the sum of all symptoms, excluding nasal congestion. The primary efficacy variable was the change from baseline in the average of the daily 12-hour evening reflective total symptom scores throughout the double-blind treatment. Safety was evaluated from adverse-event reporting, vital signs, physical examinations, and clinical laboratory data at screening and study end point.Results: Fexofenadine was significantly superior to placebo in the primary efficacy analysis (P ≤ .0001). Individual symptom scores showed statistically significant superiority compared with placebo (P < .05), including nasal congestion in the evening reflective assessment (P < .05). There was no significant difference in adverse events between fexofenadine and placebo, either overall or by causality.

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Section: Discussionmentioning

confidence: 99%

Fexofenadine is efficacious and safe in children (aged 6-11 years) with seasonal allergic rhinitis

Wahn¹,

Meltzer²,

Finn³

et al. 2003

Journal of Allergy and Clinical Immunology

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“…29 Besides another research mentioned that fexofenadine is capable of modulating T-Cell functions which resulted in preventing airway inflanmmation. 30 Recently, other aspects of fexofenadine interfering with inflammation has been reported such as reducing methacholine-induced contractions of tracheal smooth muscle.…”

Section: Anti-inflammatory Effects Of Ketotifen and Fexofenadinementioning

confidence: 99%

Evaluating the Anti-nociceptive and Anti-inflammatory Effects of Ketotifen and Fexofenadine in Rats

Anoush¹,

Khani²

2015

Adv Pharm Bull

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“…The pretreatment of the nasal mucosa and the conjunctivae with topical H 1 antihistamines has been shown to locally downregulate the inflammation after an allergen challenge [78, 79]. Decreased macrophage IL-6 production and in DCs, decreased expression of CD86 and decreased IL-8 production were shown [45, 80, 81]. …”

Section: Histamine and Chronic Inflammatory Responsesmentioning

confidence: 99%

Histamine in Allergic Inflammation and Immune Modulation

Jutel¹,

Blaser²,

Akdiş³

2005

Int Arch Allergy Immunol

117

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Histamine, originally considered as a mediator of acute inflammatory and immediate hypersensitivity responses has also been demonstrated to affect chronic inflammation and regulate several essential events in the immune response. On the other hand, various cytokines control histamine synthesis, release and expression of histamine receptors (HRs). The cells involved in the regulation of immune response and hematopoiesis express HRs and also secrete histamine, which can selectively recruit the major effector cells into tissue sites and affect their maturation, activation, polarization and effector functions leading to chronic inflammation. Histamine, acting through its receptor type 2, positively interferes with the peripheral antigen tolerance induced by T regulatory cells in several pathways. Histamine also regulates antigen-specific Th1 and Th2 cells, as well as related antibody isotype responses. The diverse effects of histamine on immune regulation are due to differential expression and regulation of four HRs and their distinct intracellular signals. In addition, differences in affinities of these receptors are highly decisive on the biological effects of histamine and agents that target HRs. This article highlights the findings leading to a change of perspective in histamine immunobiology.

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Terfenadine and Fexofenadine Reduce in Vitro ICAM-1 Expression on Human Continuous Cell Lines

Cited by 66 publications

References 25 publications

Fexofenadine is efficacious and safe in children (aged 6-11 years) with seasonal allergic rhinitis

Fexofenadine is efficacious and safe in children (aged 6-11 years) with seasonal allergic rhinitis

Evaluating the Anti-nociceptive and Anti-inflammatory Effects of Ketotifen and Fexofenadine in Rats

Histamine in Allergic Inflammation and Immune Modulation

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