Terephthalaldehyde: An Effecient Key Precursor for Novel Synthesis of Some Interesting Bis‐thiazoles and Bis‐triazolopyrimidinones

Abstract

Novel bis‐thiazoles were synthesized in high and efficient yields from the reaction of thiosemicarbazones with halogenated compounds. Also, new bis‐triazolopyrimidines were prepared from the reaction of hydrazonoyl chlorides with bis‐thione derivative. All prepared compounds were fully characterized by spectral methods. The synthesized bis‐compounds will be attractive species for the medicinal researchers to investigate their biological activity.

Recent Synthetic and Biological Developments on 1,2,4‐Triazolopyrimidines

“…[97] A synthetically efficient and experimentally simple protocol was demonstrated for synthesis of bis-triazolopyrimidines carbonitriles 205 a-f by employing 6,6'-(1,4-phenylene)bis(4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile) 203 in cyclocondensation reaction with hydrazonoyl chloride 204 as synthetically useful precursor, 1,4-dioxane/TEA as solvent system 205 a-f (Scheme 38). [98] One-pot three-component refluxing approach between terephthalic acid (1.0 equiv. ), ethyl cyanaoacetate, 2.0 equiv.)…”

Transalkylidation reaction: green, catalyst-free synthesis of thiosemicarbazones and solving the NMR conflict between their acyclic structure and intramolecular cycloaddition products

“…As well as other industrially important activities, including antifouling and anticorrosion effects (25,26) have also been reported for these compounds. Moreover, The imine bond (C = N) in these compounds are useful in the organic synthesis, in particular for the synthesis of many of pharmaceutical and bioactive heterocycles such as, thiazoles (27)(28)(29)(30)(31), 1,3,4-thiadiazoles (32), thiazolidinones (33,34), quinolines (35), naphthyridines (36), oxadiazoles (37,38), pyrimidines (39). Water plays an important role in our life.…”